PLEKHA5

PLEKHA5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2DKP
Identifiers
Aliases	PLEKHA5 , PEPP-2, PEPP2, pleckstrin homology domain containing A5
External IDs	OMIM: 607770 MGI: 1923802 HomoloGene: 10377 GeneCards: PLEKHA5
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p12.3 Start 19,129,752 bp [1] End 19,376,400 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G2 Start 140,369,780 bp [2] End 140,542,836 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell endometrium caput epididymis renal medulla corpus epididymis right adrenal gland left adrenal gland Brodmann area 23 adrenal cortex seminal vesicula Top expressed in spermatocyte superior frontal gyrus olfactory tubercle cerebellar cortex secondary oocyte olfactory bulb spermatid lip inferior ganglion of glossopharyngeal nerve cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-4-phosphate binding phosphatidylinositol-5-phosphate binding protein binding phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,5-bisphosphate binding Cellular component membrane nucleoplasm cytoplasm cytosol postsynaptic density glutamatergic synapse Biological process reproductive system development biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54477 109135 Ensembl ENSG00000052126 ENSMUSG00000030231 UniProt Q9HAU0 n/a RefSeq (mRNA) NM_001143821 NM_001190860 NM_001256470 NM_001256787 NM_019012 NM_144920 RefSeq (protein) NP_001137293 NP_001177789 NP_001243399 NP_001243716 NP_061885 NP_001137293.2 n/a Location (UCSC) Chr 12: 19.13 – 19.38 Mb Chr 6: 140.37 – 140.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pleckstrin homology domain-containing family A member 5 is a protein that in humans is encoded by the PLEKHA5 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000052126 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030231 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID   11214970.
6. Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (Jan 2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC   1221362 . PMID   11001876.
7. "Entrez Gene: PLEKHA5 pleckstrin homology domain containing, family A member 5".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200 . PMID   15951569.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.

External links

• Overview of all the structural information available in the PDB for UniProt : P00698 (Pleckstrin homology domain-containing family A member 5) at the PDBe-KB .