DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the POLR2L gene. [5]
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this unit may be shared by the other two DNA-directed RNA polymerases. [6]
POLR2L has been shown to interact with POLR2C, [7] POLR2A, [7] POLR2B [7] and POLR2E. [7]