POLR2L

Last updated

POLR2L
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLR2L , RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6, polymerase (RNA) II subunit L, RNA polymerase II subunit L, RNA polymerase II, I and III subunit L
External IDs OMIM: 601189; MGI: 1913741; HomoloGene: 129854; GeneCards: POLR2L; OMA:POLR2L - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021128

NM_025593

RefSeq (protein)

NP_066951

NP_079869

Location (UCSC) Chr 11: 0.84 – 0.84 Mb Chr 7: 141.05 – 141.06 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the POLR2L gene. [5]

Function

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this unit may be shared by the other two DNA-directed RNA polymerases. [6]

Interactions

POLR2L has been shown to interact with POLR2C, [7] POLR2A, [7] POLR2B [7] and POLR2E. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000177700 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038489 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M (September 1996). "The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase". Genomics. 32 (1): 86–90. doi:10.1006/geno.1996.0079. PMID   8786124.
  6. "Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa".
  7. 1 2 3 4 Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27): 16815–21. doi: 10.1074/jbc.272.27.16815 . PMID   9201987.

Further reading