POLR3K

POLR3K
Identifiers
Aliases	POLR3K , C11, C11-RNP3, RPC10, RPC11, RPC12.5, My010, polymerase (RNA) III subunit K, RNA polymerase III subunit K, HLD21
External IDs	OMIM: 606007 MGI: 1914255 HomoloGene: 5610 GeneCards: POLR3K
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 46,407 bp [1] End 53,608 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H4 Start 181,506,130 bp [2] End 181,512,623 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex biceps brachii thoracic diaphragm monocyte dorsolateral prefrontal cortex lymph node Brodmann area 9 nucleus accumbens embryo appendix Top expressed in ciliary body retinal pigment epithelium iris medial ganglionic eminence otic placode abdominal wall maxillary prominence primitive streak urothelium Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding DNA-directed 5'-3' RNA polymerase activity zinc ion binding metal ion binding RNA polymerase III activity Cellular component RNA polymerase III complex cytosol nucleolus nucleus nucleoplasm Biological process immune system process defense response to virus transcription, DNA-templated transcription by RNA polymerase III innate immune response termination of RNA polymerase III transcription tRNA 3'-trailer cleavage positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51728 67005 Ensembl ENSG00000161980 ENSMUSG00000038628 UniProt Q9Y2Y1 Q9CQZ7 RefSeq (mRNA) NM_016310 NM_025901 RefSeq (protein) NP_057394 NP_080177 Location (UCSC) Chr 16: 0.05 – 0.05 Mb Chr 2: 181.51 – 181.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC10 is an enzyme that in humans is encoded by the POLR3K gene. ^{[5] [6] [7]}

This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes.

The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000161980 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038628 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chedin S, Riva M, Schultz P, Sentenac A, Carles C (Jan 1999). "The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination". Genes Dev. 12 (24): 3857–71. doi:10.1101/gad.12.24.3857. PMC   317263 . PMID   9869639.
6. Spakovskii GV, Lebedenko EN (Mar 1999). "[Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III]". Bioorg Khim. 24 (11): 877–80. PMID   10079944.
7. "Entrez Gene: POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa".

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID   1403646.
• Flint J, Thomas K, Micklem G, et al. (1997). "The relationship between chromosome structure and function at a human telomeric region". Nat. Genet. 15 (3): 252–7. doi:10.1038/ng0397-252. PMID   9054936. S2CID   20630444.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID   11157797.
• Hu P, Wu S, Sun Y, et al. (2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Mol. Cell. Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC   134740 . PMID   12391170.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi: 10.1038/nature03187 . PMID   15616553.
• De Gobbi M, Viprakasit V, Hughes JR, et al. (2006). "A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter". Science. 312 (5777): 1215–7. Bibcode:2006Sci...312.1215D. doi:10.1126/science.1126431. PMID   16728641. S2CID   16044469.
• Johnson SS, Zhang C, Fromm J, et al. (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases". Mol. Cell. 26 (3): 367–79. doi: 10.1016/j.molcel.2007.03.021 . PMID   17499043.