PPP1R10

PPP1R10
Identifiers
Aliases	PPP1R10 , CAT53, FB19, PNUTS, PP1R10, R111, p99, protein phosphatase 1 regulatory subunit 10
External IDs	OMIM: 603771 MGI: 1289273 HomoloGene: 2033 GeneCards: PPP1R10
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,618,612 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	36,243,175 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; sural nerve; ; thymus; ; gallbladder; ; appendix; ; urinary bladder; ; right uterine tube; ; rectum; ; Achilles tendon; ; smooth muscle tissue;
	Top expressed in
	testicle; ; secondary oocyte; ; spermatid; ; spermatocyte; ; uterus; ; ganglionic eminence; ; yolk sac; ; islet of Langerhans; ; bone marrow; ; adrenal gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase inhibitor activity ; DNA binding ; metal ion binding ; RNA binding ; protein binding ;
Cellular component	chromatin ; PTW/PP1 phosphatase complex ; nucleus ; nucleoplasm ; nuclear body ;
Biological process	negative regulation of catalytic activity ; protein import into nucleus ; negative regulation of cardiac muscle cell apoptotic process ; positive regulation of telomere maintenance ; negative regulation of phosphoprotein phosphatase activity ; negative regulation of mitotic DNA damage checkpoint ;
	Sources:Amigo / QuickGO
Orthologs
	5514
	52040
ENSG00000227804 ; ENSG00000238104 ; ENSG00000206489 ; ENSG00000230995 ; ENSG00000235291 ;
	ENSG00000231737 ; ENSG00000204569
	ENSMUSG00000039220
	Q96QC0
	Q80W00
	NM_002714 ; NM_001376195
	NM_001163818 ; NM_175934 ; NM_001357740
	NP_002705 ; NP_001363124
	NP_001157290 ; NP_001344669 ; NP_001390493
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.^[5]^[6]^[7]

Function

This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis.^[7]

Related Research Articles

A protein phosphatase is a phosphatase enzyme that removes a phosphate group from the phosphorylated amino acid residue of its substrate protein. Protein phosphorylation is one of the most common forms of reversible protein posttranslational modification (PTM), with up to 30% of all proteins being phosphorylated at any given time. Protein kinases (PKs) are the effectors of phosphorylation and catalyse the transfer of a γ-phosphate from ATP to specific amino acids on proteins. Several hundred PKs exist in mammals and are classified into distinct super-families. Proteins are phosphorylated predominantly on Ser, Thr and Tyr residues, which account for 79.3, 16.9 and 3.8% respectively of the phosphoproteome, at least in mammals. In contrast, protein phosphatases (PPs) are the primary effectors of dephosphorylation and can be grouped into three main classes based on sequence, structure and catalytic function. The largest class of PPs is the phosphoprotein phosphatase (PPP) family comprising PP1, PP2A, PP2B, PP4, PP5, PP6 and PP7, and the protein phosphatase Mg²⁺- or Mn²⁺-dependent (PPM) family, composed primarily of PP2C. The protein Tyr phosphatase (PTP) super-family forms the second group, and the aspartate-based protein phosphatases the third. The protein pseudophosphatases form part of the larger phosphatase family, and in most cases are thought to be catalytically inert, instead functioning as phosphate-binding proteins, integrators of signalling or subcellular traps. Examples of membrane-spanning protein phosphatases containing both active (phosphatase) and inactive (pseudophosphatase) domains linked in tandem are known, conceptually similar to the kinase and pseudokinase domain polypeptide structure of the JAK pseudokinases. A complete comparative analysis of human phosphatases and pseudophosphatases has been completed by Manning and colleagues, forming a companion piece to the ground-breaking analysis of the human kinome, which encodes the complete set of ~536 human protein kinases.

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.

Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.

Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene.

Protein phosphatase 1 regulatory subunit 3A is an enzyme that in humans is encoded by the PPP1R3A gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.

Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the STK38 gene.

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene.

Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene.

Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the STK24 gene located in the chromosome 13, band q32.2. It is also known as Mammalian STE20-like protein kinase 3 (MST-3). The protein is 443 amino acids long and its mass is 49 kDa.

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.

Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene.

MASTL is an official symbol provided by HGNC for human gene whose official name is micro tubule associated serine/threonine kinase like. This gene is 32,1 kbps long. This gene is also known as GW, GWL, THC2, MAST-L, GREATWALL. This is present in mainly mammalian cells like human, house mouse, cattle, monkey, etc. It is in the 10th chromosome of the mammalian nucleus. Recent studies have been carried on zebrafish and frogs. This gene encodes for the protein micro tubule associated serine/threonine kinase and its sub-classes.

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PP2BC) is an enzyme that in humans is encoded by the PPP3CC gene.

References

1 2 3 ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 GRCh38: Ensembl release 89: ENSG00000227804, ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039220 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Allen PB, Kwon YG, Nairn AC, Greengard P (Mar 1998). "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit". J Biol Chem. 273 (7): 4089–95. doi: 10.1074/jbc.273.7.4089 . PMID 9461602.
↑ Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P (Nov 1998). "Cloning of a new gene (FB19) within HLA class I region". Biochem Biophys Res Commun. 250 (3): 555–7. doi:10.1006/bbrc.1998.9354. PMID 9784381.
1 2 "Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10".

Totaro A, Rommens JM, Grifa A, et al. (1997). "Hereditary hemochromatosis: generation of a transcription map within a refined and extended map of the HLA class I region". Genomics. 31 (3): 319–26. doi:10.1006/geno.1996.0054. PMID 8838313.
Kreivi JP, Trinkle-Mulcahy L, Lyon CE, et al. (1998). "Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity". FEBS Lett. 420 (1): 57–62. doi:10.1016/S0014-5793(97)01485-3. PMID 9450550. S2CID 23856958.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kim YM, Watanabe T, Allen PB, et al. (2003). "PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation". J. Biol. Chem. 278 (16): 13819–28. doi: 10.1074/jbc.M209621200 . PMID 12574161.
Reeder JE, Sowden MP, Messing EM, et al. (2003). "Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line". Cancer Cell International. 3 (1): 12. doi:10.1186/1475-2867-3-12. PMC 183861 . PMID 12914669.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi: 10.1038/nature02055 . PMID 14574404.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Raha-Chowdhury R, Andrews SR, Gruen JR (2005). "CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease". Brain Res. Mol. Brain Res. 138 (1): 70–83. doi:10.1016/j.molbrainres.2005.04.001. PMID 15894402.
Landsverk HB, Kirkhus M, Bollen M, et al. (2006). "PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner". Biochem. J. 390 (Pt 3): 709–17. doi:10.1042/BJ20050678. PMC 1199665 . PMID 15907195.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Lee SJ, Lim CJ, Min JK, et al. (2007). "Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2". Cell Death Differ. 14 (6): 1106–16. doi: 10.1038/sj.cdd.4402111 . PMID 17318220.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 GRCh38: Ensembl release 89: ENSG00000227804, ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039220 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9461602-5] Allen PB, Kwon YG, Nairn AC, Greengard P (Mar 1998). "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit". J Biol Chem. 273 (7): 4089–95. doi: 10.1074/jbc.273.7.4089 . PMID 9461602.

[pmid9784381-6] Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P (Nov 1998). "Cloning of a new gene (FB19) within HLA class I region". Biochem Biophys Res Commun. 250 (3): 555–7. doi:10.1006/bbrc.1998.9354. PMID 9784381.

[entrez-7] 1 2 "Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10".

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PPP1R10

Contents

Function

Related Research Articles

References

Further reading