PPP1R17

PPP1R17
Identifiers
Aliases	PPP1R17 , C7orf16, GSBS, protein phosphatase 1 regulatory subunit 17
External IDs	OMIM: 604088 MGI: 1333876 HomoloGene: 4849 GeneCards: PPP1R17
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p14.3 Start 31,687,215 bp [1] End 31,708,455 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 B3|6 27.65 cM Start 55,994,482 bp [2] End 56,009,674 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence cerebellar vermis hypothalamus pons anterior pituitary monocyte cingulate gyrus prefrontal cortex substantia nigra ventral tegmental area Top expressed in cerebellar vermis trigeminal ganglion suprachiasmatic nucleus dorsomedial hypothalamic nucleus endocardial cushion superior cervical ganglion adrenal gland atrioventricular valve morula pituitary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase inhibitor activity protein serine/threonine phosphatase inhibitor activity phosphatase inhibitor activity Cellular component cellular component nucleoplasm Biological process regulation of phosphatase activity central nervous system development intracellular signal transduction negative regulation of catalytic activity negative regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10842 19051 Ensembl ENSG00000106341 ENSMUSG00000002930 UniProt O96001 Q9Z2E4 RefSeq (mRNA) NM_001145123 NM_006658 NM_011153 RefSeq (protein) NP_001138595 NP_006649 NP_035283 Location (UCSC) Chr 7: 31.69 – 31.71 Mb Chr 6: 55.99 – 56.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein phosphatase 1 regulatory subunit 17 is a protein that in humans is encoded by the PPP1R17 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000106341 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002930 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M (Mar 1999). "Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2467–72. Bibcode:1999PNAS...96.2467E. doi: 10.1073/pnas.96.5.2467 . PMC   26808 . PMID   10051666.
6. Hall KU, Collins SP, Gamm DM, Massa E, DePaoli-Roach AA, Uhler MD (Feb 1999). "Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry. 274 (6): 3485–95. doi: 10.1074/jbc.274.6.3485 . PMID   9920894.
7. "Entrez Gene: C7orf16 chromosome 7 open reading frame 16".

External links

• Human PPP1R17 genome location and PPP1R17 gene details page in the UCSC Genome Browser .

Further reading

• Ono S, Ezura Y, Emi M, Fujita Y, Takada D, Sato K, Ishigami T, Umemura S, Takahashi K, Kamimura K, Bujo H, Saito Y (2003). "A promoter SNP (-1323T>C) in G-substrate gene (GSBS) correlates with hypercholesterolemia". Journal of Human Genetics. 48 (9): 447–50. doi: 10.1007/s10038-003-0055-x . PMID   12955585.
• Sanger Centre T, Washington University Genome Sequencing Cente T (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.