PPP1R9A

PPP1R9A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1WF8
Identifiers
Aliases	PPP1R9A , NRB1, NRBI, Neurabin-I, protein phosphatase 1 regulatory subunit 9A
External IDs	OMIM: 602468 MGI: 2442401 HomoloGene: 14247 GeneCards: PPP1R9A
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q21.3 Start 94,907,202 bp [1] End 95,296,415 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 A1|6 1.86 cM Start 4,902,917 bp [2] End 5,165,661 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell parietal lobe postcentral gyrus cerebellar vermis entorhinal cortex pons external globus pallidus middle temporal gyrus optic nerve Top expressed in olfactory tubercle nucleus accumbens ventromedial nucleus globus pallidus primary motor cortex arcuate nucleus cingulate gyrus subiculum prefrontal cortex substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein domain specific binding protein phosphatase 1 binding protein binding GTPase binding actin binding actin filament binding protein C-terminus binding protein kinase binding transmembrane transporter binding protein-containing complex binding Cellular component dendritic spine neck cytosol filopodium growth cone neuromuscular junction dendritic spine synapse growth cone lamellipodium cell junction neuronal cell body cortical actin cytoskeleton neuron projection cytoskeleton lamellipodium cytoplasm postsynaptic density actin cytoskeleton dendrite postsynaptic actin cytoskeleton glutamatergic synapse Biological process regulation of filopodium assembly cell differentiation regulation of synapse structural plasticity regulation of synapse assembly ageing cellular response to toxic substance neuron development positive regulation of dendritic spine development nervous system development multicellular organism development regulation of actin filament polymerization excitatory postsynaptic potential negative regulation of long-term synaptic potentiation negative regulation of spontaneous neurotransmitter secretion positive regulation of long-term synaptic depression positive regulation of neuron projection development negative regulation of stress fiber assembly regulation of dendritic spine morphogenesis positive regulation of protein kinase activity actin filament organization calcium-mediated signaling neuron projection development modulation of chemical synaptic transmission postsynaptic actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55607 243725 Ensembl ENSG00000158528 ENSMUSG00000032827 UniProt Q9ULJ8 n/a RefSeq (mRNA) NM_001166160 NM_001166161 NM_001166162 NM_001166163 NM_017650 NM_181595 NM_001363809 RefSeq (protein) NP_001159632 NP_001159633 NP_001159634 NP_001159635 NP_060120 NP_001159635.1 n/a Location (UCSC) Chr 7: 94.91 – 95.3 Mb Chr 6: 4.9 – 5.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neurabin-1 is a protein that in humans is encoded by the PPP1R9A gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000158528 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032827 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
6. "Entrez Gene: PPP1R9A protein phosphatase 1, regulatory (inhibitor) subunit 9A".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Nakanishi H, Obaishi H, Satoh A, et al. (1997). "Neurabin: A Novel Neural Tissue–specific Actin Filament–binding Protein Involved in Neurite Formation". J. Cell Biol. 139 (4): 951–61. doi:10.1083/jcb.139.4.951. PMC   2139968 . PMID   9362513.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• McAvoy T, Allen PB, Obaishi H, et al. (1999). "Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation". Biochemistry. 38 (39): 12943–9. doi:10.1021/bi991227d. PMID   10504266.
• Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi: 10.1074/jbc.274.42.30080 . PMID   10514494.
• Oliver CJ, Terry-Lorenzo RT, Elliott E, et al. (2002). "Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology". Mol. Cell. Biol. 22 (13): 4690–701. doi:10.1128/MCB.22.13.4690-4701.2002. PMC   133892 . PMID   12052877.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.