PPP2R5C

PPP2R5C
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2IAE, 2JAK, 2NPP, 2NYL, 2NYM, 3FGA, 5JJA
Identifiers
Aliases	PPP2R5C , B56G, PR61G, protein phosphatase 2 regulatory subunit B'gamma, B56gamma
External IDs	OMIM: 601645 HomoloGene: 135298 GeneCards: PPP2R5C
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.31 Start 101,761,798 bp [1] End 101,927,989 bp [1]
RNA expression pattern Bgee Top expressed in lymph node lung heart thymus caudate nucleus testicle bone marrow nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GO:0001948 protein binding protein phosphatase regulator activity protein phosphatase activator activity Cellular component protein phosphatase type 2A complex chromosome, centromeric region nucleus chromosome nucleoplasm Golgi apparatus cytosol Biological process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest signal transduction negative regulation of cell population proliferation proteasome-mediated ubiquitin-dependent protein catabolic process regulation of phosphatidylinositol 3-kinase signaling regulation of phosphoprotein phosphatase activity regulation of protein autophosphorylation protein dephosphorylation negative regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5527	n/a
Ensembl	ENSG00000078304	n/a
UniProt	Q13362	n/a
RefSeq (mRNA)	NM_001161725 NM_001161726 NM_002719 NM_178586 NM_178587 NM_178588 NM_001352912 NM_001352913 NM_001352914 NM_001352915 NM_001352916	n/a
RefSeq (protein)	NP_001155197 NP_001155198 NP_002710 NP_848701 NP_848702 NP_001339841 NP_001339842 NP_001339843 NP_001339844 NP_001339845	n/a
Location (UCSC)	Chr 14: 101.76 – 101.93 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene. ^{[3] [4]}

Function

The product of this gene belongs to the Protein phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. ^[4]

Interactions

PPP2R5C has been shown to interact with PPP2R1B, ^[5] PPP2CA ^{[5] [6] [7]} and PPP2R5A. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000078304 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry. 270 (44): 26123–8. doi: 10.1074/jbc.270.44.26123 . PMID   7592815.
4. "Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform".
5. McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi: 10.1074/jbc.271.36.22081 . PMID   8703017.
6. Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H (Feb 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal. 19 (4): 562–71. doi:10.1093/emboj/19.4.562. PMC   305594 . PMID   10675325.
7. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC   2621004 . PMID   18782753.
8. Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT (Jun 2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". The Journal of Biological Chemistry. 277 (23): 20750–5. doi: 10.1074/jbc.M202992200 . PMID   11929880.

Further reading

• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMC   554975 . PMID   15725353.
• Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi: 10.1038/sj.cr.7290279 . PMID   15780175.
• Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID   15817944.
• Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Research. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi: 10.1093/dnares/1.5.223 . PMID   7584044.
• Akiyama N, Shima H, Hatano Y, Osawa Y, Sugimura T, Nagao M (Jun 1995). "cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase". European Journal of Biochemistry. 230 (2): 766–72. doi:10.1111/j.1432-1033.1995.tb20619.x. PMID   7607250.
• Tehrani MA, Mumby MC, Kamibayashi C (Mar 1996). "Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle". The Journal of Biological Chemistry. 271 (9): 5164–70. doi: 10.1074/jbc.271.9.5164 . PMID   8617797.
• Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA (Jul 1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". The Biochemical Journal. 317 (Pt 1): 187–94. doi:10.1042/bj3170187. PMC   1217462 . PMID   8694763.
• McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi: 10.1074/jbc.271.36.22081 . PMID   8703017.
• McCright B, Brothman AR, Virshup DM (Aug 1996). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics. 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID   8812429.
• Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2–3): 197–201. doi: 10.1016/S0014-5793(96)01470-6 . PMID   9013886.
• Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi: 10.1006/viro.1997.8873 . PMID   9400615.
• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi: 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . PMID   10508479.
• Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H (Feb 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal. 19 (4): 562–71. doi:10.1093/emboj/19.4.562. PMC   305594 . PMID   10675325.
• Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A (Jan 2000). "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin". Oncogene. 19 (4): 537–45. doi: 10.1038/sj.onc.1203359 . PMID   10698523.
• Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi: 10.1006/viro.2001.1007 . PMID   11531413.
• Muneer S, Ramalingam V, Wyatt R, Schultz RA, Minna JD, Kamibayashi C (Mar 2002). "Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit". Genomics. 79 (3): 344–8. doi:10.1006/geno.2002.6721. PMID   11863364.
• Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT (Jun 2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". The Journal of Biological Chemistry. 277 (23): 20750–5. doi: 10.1074/jbc.M202992200 . PMID   11929880.