PPP2R5D

PPP2R5D
Identifiers
Aliases	PPP2R5D , B56D, MRD35, protein phosphatase 2 regulatory subunit B'delta, B56delta
External IDs	OMIM: 601646 MGI: 2388481 HomoloGene: 37661 GeneCards: PPP2R5D
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,012,342 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	47,016,037 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; prefrontal cortex; ; smooth muscle tissue; ; stromal cell of endometrium; ; pancreatic ductal cell; ; gastrocnemius muscle; ; nucleus accumbens; ; canal of the cervix; ; right coronary artery; ; gastric mucosa;
	Top expressed in
	yolk sac; ; superior frontal gyrus; ; maxillary prominence; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; neural tube; ; cerebellar cortex; ; internal carotid artery; ; medial geniculate nucleus; ; somite;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine phosphatase activity ; protein binding ; protein phosphatase regulator activity ; phosphoprotein phosphatase activity ; protein phosphatase activator activity ;
Cellular component	cytoplasm ; cytosol ; protein phosphatase type 2A complex ; nucleoplasm ; nucleus ;
Biological process	nervous system development ; signal transduction ; positive regulation of protein dephosphorylation ; protein dephosphorylation ; regulation of phosphoprotein phosphatase activity ; negative regulation of peptidyl-threonine phosphorylation ; regulation of protein autophosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	5528
	21770
	ENSG00000112640
	ENSMUSG00000059409
	Q14738
	n/a
	NM_180977 ; NM_001270476 ; NM_006245 ; NM_180976
	NM_009358 ; NM_001357684
	NP_001257405 ; NP_006236 ; NP_851307 ; NP_851308
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene.^[5]^[6] Mutations in PPP2R5D cause Jordan's Syndrome.

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

Interactions

PPP2R5D has been shown to interact with:

Related Research Articles

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that is encoded by the PPP2CA gene.

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

COP9 signalosome complex subunit 6 is a protein that in humans is encoded by the COPS6 gene.

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the PPP2R5A gene.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the PPP2R2A gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the PPP2R1B gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.

Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the IGBP1 gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta is an enzyme that in humans is encoded by the PPP2R3B gene.

Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. Its serine/threonine phosphatase activity has a broad substrate specificity and diverse cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT, where PP2A may act as a tumor suppressor.

Protein phosphatase 1 (PP1) belongs to a certain class of phosphatases known as protein serine/threonine phosphatases. This type of phosphatase includes metal-dependent protein phosphatases (PPMs) and aspartate-based phosphatases. PP1 has been found to be important in the control of glycogen metabolism, muscle contraction, cell progression, neuronal activities, splicing of RNA, mitosis, cell division, apoptosis, protein synthesis, and regulation of membrane receptors and channels.

Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. Phosphorylation enables the activation or The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits, this family is called the B56 family.

PP2A subunit B isoform delta also known as serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform is a protein that in humans is encoded by the PPP2R2D gene. It is a regulatory subunit of the heterotrimeric protein phosphatase 2 enzyme.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112640 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059409 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ McCright B, Virshup DM (Dec 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J Biol Chem. 270 (44): 26123–8. doi: 10.1074/jbc.270.44.26123 . PMID 7592815.
1 2 "Entrez Gene: PPP2R5D protein phosphatase 2, regulatory subunit B', delta isoform".
↑ Firulli BA, Howard MJ, McDaid JR, McIlreavey L, Dionne KM, Centonze VE, Cserjesi P, Virshup DM, Firulli AB (Nov 2003). "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation". Mol. Cell. 12 (5): 1225–37. doi: 10.1016/S1097-2765(03)00425-8 . PMID 14636580.
1 2 McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. 271 (36): 22081–9. doi: 10.1074/jbc.271.36.22081 . PMID 8703017.
↑ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004 . PMID 18782753.
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi: 10.1186/1742-4690-2-11 . PMC 554975 . PMID 15725353.
Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi: 10.1038/sj.cr.7290279 . PMID 15780175.
Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
Tanabe O, Nagase T, Murakami T, Nozaki H, Usui H, Nishito Y, Hayashi H, Kagamiyama H, Takeda M (1996). "Molecular cloning of a 74-kDa regulatory subunit (B" or delta) of human protein phosphatase 2A". FEBS Lett. 379 (1): 107–11. doi: 10.1016/0014-5793(95)01500-0 . PMID 8566219. S2CID 86538311.
McCright B, Rivers AM, Audlin S, Virshup DM (1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. 271 (36): 22081–9. doi: 10.1074/jbc.271.36.22081 . PMID 8703017.
McCright B, Brothman AR, Virshup DM (1997). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics. 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID 8812429.
Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. doi: 10.1016/S0014-5793(96)01470-6 . PMID 9013886. S2CID 23293768.
Tanabe O, Gomez GA, Nishito Y, Usui H, Takeda M (1997). "Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory subunit (B" or delta) of human protein phosphatase 2A". FEBS Lett. 408 (1): 52–6. doi: 10.1016/S0014-5793(97)00392-X . PMID 9180267. S2CID 83580635.
Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi: 10.1006/viro.1997.8873 . PMID 9400615.
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi: 10.1006/viro.2001.1007 . PMID 11531413.
Hrimech M, Yao XJ, Branton PE, Cohen EA (2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMC 126131 . PMID 12110603.
Firulli BA, Howard MJ, McDaid JR, McIlreavey L, Dionne KM, Centonze VE, Cserjesi P, Virshup DM, Firulli AB (2004). "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation". Mol. Cell. 12 (5): 1225–37. doi: 10.1016/S1097-2765(03)00425-8 . PMID 14636580.
Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112640 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059409 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7592815-5] McCright B, Virshup DM (Dec 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J Biol Chem. 270 (44): 26123–8. doi: 10.1074/jbc.270.44.26123 . PMID 7592815.

[entrez-6] 1 2 "Entrez Gene: PPP2R5D protein phosphatase 2, regulatory subunit B', delta isoform".

[pmid14636580-7] Firulli BA, Howard MJ, McDaid JR, McIlreavey L, Dionne KM, Centonze VE, Cserjesi P, Virshup DM, Firulli AB (Nov 2003). "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation". Mol. Cell. 12 (5): 1225–37. doi: 10.1016/S1097-2765(03)00425-8 . PMID 14636580.

[pmid8703017-8] 1 2 McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. 271 (36): 22081–9. doi: 10.1074/jbc.271.36.22081 . PMID 8703017.

[pmid18782753-9] Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004 . PMID 18782753.

[pmid16189514-10] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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PPP2R5D

Contents

Function

Interactions

Related Research Articles

References

Further reading