PPP2R5E

PPP2R5E
Identifiers
Aliases	PPP2R5E , protein phosphatase 2 regulatory subunit B'epsilon, B56epsilon, B56E
External IDs	OMIM: 601647; MGI: 1349473; HomoloGene: 55962; GeneCards: PPP2R5E; OMA:PPP2R5E - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q23.2 Start 63,371,364 bp [1] End 63,543,377 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C3 Start 75,497,655 bp [2] End 75,643,019 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell mucosa of ileum tibialis anterior muscle ganglionic eminence buccal mucosa cell endothelial cell deltoid muscle pericardium ventricular zone Brodmann area 23 Top expressed in Rostral migratory stream retinal pigment epithelium facial motor nucleus ciliary body human fetus hand ventromedial nucleus medial ganglionic eminence left lung lobe nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein phosphatase regulator activity protein phosphatase activator activity Cellular component protein phosphatase type 2A complex cytoplasm cytosol nucleus Biological process signal transduction regulation of phosphoprotein phosphatase activity regulation of protein autophosphorylation protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5529 26932 Ensembl ENSG00000154001 ENSMUSG00000021051 UniProt Q16537 Q61151 RefSeq (mRNA) NM_001282179 NM_001282180 NM_001282181 NM_001282182 NM_006246 NM_001354926 NM_012024 RefSeq (protein) NP_001269108 NP_001269109 NP_001269110 NP_001269111 NP_006237 NP_001341855 NP_036154 Location (UCSC) Chr 14: 63.37 – 63.54 Mb Chr 12: 75.5 – 75.64 Mb PubMed search [3] [4]
Wikidata
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Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene. ^{[5] [6]}

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. ^[6]

Interactions

PPP2R5E has been shown to interact with PPP2R1B ^[7] and PPP2CA. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000154001 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021051 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry. 270 (44): 26123–8. doi: 10.1074/jbc.270.44.26123 . PMID   7592815.
6. "Entrez Gene: PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform".
7. McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi: 10.1074/jbc.271.36.22081 . PMID   8703017.
8. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi: 10.1074/mcp.M800266-MCP200 . PMC   2621004 . PMID   18782753.

Further reading

• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi: 10.1186/1742-4690-2-11 . PMC   554975 . PMID   15725353.
• Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi: 10.1038/sj.cr.7290279 . PMID   15780175.
• Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID   15817944.
• Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA (Jul 1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". The Biochemical Journal. 317 (Pt 1): 187–94. doi:10.1042/bj3170187. PMC   1217462 . PMID   8694763.
• McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi: 10.1074/jbc.271.36.22081 . PMID   8703017.
• McCright B, Brothman AR, Virshup DM (Aug 1996). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics. 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID   8812429.
• Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2–3): 197–201. doi: 10.1016/S0014-5793(96)01470-6 . PMID   9013886.
• Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi: 10.1006/viro.1997.8873 . PMID   9400615.
• Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi: 10.1006/viro.2001.1007 . PMID   11531413.
• Hrimech M, Yao XJ, Branton PE, Cohen EA (Jul 2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". The EMBO Journal. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMC   126131 . PMID   12110603.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Dozier C, Bonyadi M, Baricault L, Tonasso L, Darbon JM (Sep 2004). "Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit". Biology of the Cell. 96 (7): 509–17. doi: 10.1016/j.biolcel.2004.04.010 . PMID   15380617.
• Ammosova T, Washington K, Debebe Z, Brady J, Nekhai S (2006). "Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription". Retrovirology. 2: 47. doi: 10.1186/1742-4690-2-47 . PMC   1187922 . PMID   16048649.