PRB3

PRB3
Identifiers
Aliases	PRB3 , G1, PRG, proline-rich protein BstNI subfamily 3, proline rich protein BstNI subfamily 3
External IDs	OMIM: 168840 HomoloGene: 133260 GeneCards: PRB3
Gene location (Human)
Chr.	Chromosome 12 (human)
End	11,269,707 bp
RNA expression pattern
	Top expressed in
	thymus; ; bone marrow; ; bone marrow cells; ; sural nerve; ; salivary gland; ; rectum; ; skin of abdomen; ; urinary bladder; ; mucosa of large intestine; ; minor salivary glands;
	n/a
	More reference expression data
	; ;
	More reference expression data
Orthologs
	5544
	n/a
	ENSG00000197870 ; ENSG00000275624
	n/a
	Q04118
	n/a
	NM_006249 ; NM_001394862
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated May 22, 2024

Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene.^[3]^[4]

The protein encoded by this gene is a proline-rich salivary protein. It is a major constituent of parotid saliva. This protein is proposed to act as a bacterial receptor. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.^[4]

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References

1 2 3 ENSG00000275624 GRCh38: Ensembl release 89: ENSG00000197870, ENSG00000275624 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gillece-Castro BL, Prakobphol A, Burlingame AL, Leffler H, Fisher SJ (Oct 1991). "Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein". J Biol Chem. 266 (26): 17358–68. doi: 10.1016/S0021-9258(19)47381-X . PMID 1894623.
1 2 "Entrez Gene: PRB3 proline-rich protein BstNI subfamily 3".

Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 17. pp. 141–99. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. PMID 3055850.
Azen EA, Minaguchi K, Latreille P, Kim HS (1990). "Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew". Am. J. Hum. Genet. 47 (4): 686–97. PMC 1683781 . PMID 2171329.
Lyons KM, Stein JH, Smithies O (1989). "Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC 1203497 . PMID 2851479.
Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi: 10.1016/S0021-9258(17)39156-1 . PMID 2993301.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Azen E, Prakobphol A, Fisher SJ (1993). "PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro". Infect. Immun. 61 (10): 4434–9. doi:10.1128/IAI.61.10.4434-4439.1993. PMC 281176 . PMID 8406834.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000275624 GRCh38: Ensembl release 89: ENSG00000197870, ENSG00000275624 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1894623-3] Gillece-Castro BL, Prakobphol A, Burlingame AL, Leffler H, Fisher SJ (Oct 1991). "Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein". J Biol Chem. 266 (26): 17358–68. doi: 10.1016/S0021-9258(19)47381-X . PMID 1894623.

[entrez-4] 1 2 "Entrez Gene: PRB3 proline-rich protein BstNI subfamily 3".

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[2]

[3]

[4]

PRB3

Related Research Articles

References

Further reading