PSTPIP1

PSTPIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DIL
Identifiers
Aliases	PSTPIP1 , CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP, proline-serine-threonine phosphatase interacting protein 1
External IDs	OMIM: 606347 MGI: 1321396 HomoloGene: 37867 GeneCards: PSTPIP1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	77,037,475 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	56,036,172 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spleen; ; bone marrow cells; ; lymph node; ; appendix; ; Achilles tendon; ; upper lobe of left lung; ; ascending aorta; ; right lung;
	Top expressed in
	thymus; ; blood; ; molar; ; gastric mucosa; ; mucous cell of stomach; ; spleen; ; esophagus; ; epithelium of stomach; ; pyloric antrum; ; body of femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; identical protein binding ; cytoskeletal protein binding ; actin filament binding ;
Cellular component	cytoplasm ; perinuclear region of cytoplasm ; cytosol ; plasma membrane ; uropod ; cleavage furrow ; cell projection ; cytoskeleton ; membrane ; lamellipodium ; actin filament ;
Biological process	cell adhesion ; inflammatory response ; endocytosis ; signal transduction ; immune system process ; innate immune response ; actin filament polymerization ; cell migration ;
	Sources:Amigo / QuickGO
Orthologs
	9051
	19200
	ENSG00000140368
	ENSMUSG00000032322
	O43586
	P97814
	NM_003978 ; NM_001321135 ; NM_001321136 ; NM_001321137
	NM_011193
	NP_001308064 ; NP_001308065 ; NP_001308066 ; NP_003969
	NP_035323
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 12, 2024

Proline-serine-threonine phosphatase-interacting protein 1 is an enzyme that in humans is encoded by the PSTPIP1 gene.^[5]^[6]

Interactions

PSTPIP1 has been shown to interact with:

Related Research Articles

The Wiskott–Aldrich Syndrome protein (WASp) is a 502-amino acid protein expressed in cells of the hematopoietic system that in humans is encoded by the WAS gene. In the inactive state, WASp exists in an autoinhibited conformation with sequences near its C-terminus binding to a region near its N-terminus. Its activation is dependent upon CDC42 and PIP2 acting to disrupt this interaction, causing the WASp protein to 'open'. This exposes a domain near the WASp C-terminus that binds to and activates the Arp2/3 complex. Activated Arp2/3 nucleates new F-actin.

Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene located on chromosome 9. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus.

<span class="mw-page-title-main">PTPN11</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.

Wiskott–Aldrich syndrome protein family member 2 is a protein that in humans is encoded by the WASF2 gene.

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

Receptor-type tyrosine-protein phosphatase alpha is an enzyme that in humans is encoded by the PTPRA gene.

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.

Wiskott–Aldrich syndrome protein family member 1, also known as WASP-family verprolin homologous protein 1 (WAVE1), is a protein that in humans is encoded by the WASF1 gene.

CD2-associated protein is a protein that in humans is encoded by the CD2AP gene.

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.

Serine/threonine-protein kinase N2 is an enzyme that in humans and Strongylocentrotus purpuratus is encoded by the PKN2 gene.

Protein tyrosine phosphatase non-receptor type 7 is an enzyme that in humans is encoded by the PTPN7 gene.

Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the PTPRS gene.

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000140368 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032322 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (February 1999). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078 . PMID 9857189.
↑ "Entrez Gene: PSTPIP1 proline-serine-threonine phosphatase interacting protein 1".
↑ Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA, Goff SP (December 2000). "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation". Mol. Cell. 6 (6): 1413–23. doi: 10.1016/s1097-2765(00)00138-6 . PMID 11163214.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
↑ Dowbenko D, Spencer S, Quan C, Lasky LA (January 1998). "Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein". J. Biol. Chem. 273 (2): 989–96. doi: 10.1074/jbc.273.2.989 . PMID 9422760.
↑ Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, Simanis V, Lasky LA (August 1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase". J. Cell Biol. 138 (4): 845–60. doi:10.1083/jcb.138.4.845. PMC 2138048 . PMID 9265651.
↑ Wu Y, Spencer SD, Lasky LA (March 1998). "Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott–Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein". J. Biol. Chem. 273 (10): 5765–70. doi: 10.1074/jbc.273.10.5765 . PMID 9488710.

Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, Simanis V, Lasky LA (1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase". J. Cell Biol. 138 (4): 845–60. doi:10.1083/jcb.138.4.845. PMC 2138048 . PMID 9265651.
Dowbenko D, Spencer S, Quan C, Lasky LA (1998). "Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein". J. Biol. Chem. 273 (2): 989–96. doi: 10.1074/jbc.273.2.989 . PMID 9422760.
Wu Y, Spencer SD, Lasky LA (1998). "Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott–Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein". J. Biol. Chem. 273 (10): 5765–70. doi: 10.1074/jbc.273.10.5765 . PMID 9488710.
Wu Y, Dowbenko D, Lasky LA (1998). "PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase". J. Biol. Chem. 273 (46): 30487–96. doi: 10.1074/jbc.273.46.30487 . PMID 9804817.
Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA, Goff SP (2000). "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation". Mol. Cell. 6 (6): 1413–23. doi: 10.1016/S1097-2765(00)00138-6 . PMID 11163214.
Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, Handa M, Ikebuchi K, Ikeda H (2001). "CrkL is an adapter for Wiskott–Aldrich syndrome protein and Syk". Blood. 97 (9): 2633–9. doi: 10.1182/blood.V97.9.2633 . PMID 11313252.
Côté JF, Chung PL, Théberge JF, Hallé M, Spencer S, Lasky LA, Tremblay ML (2002). "PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP". J. Biol. Chem. 277 (4): 2973–86. doi: 10.1074/jbc.M106428200 . PMID 11711533.
Wise CA, Gillum JD, Seidman CE, Lindor NM, Veile R, Bashiardes S, Lovett M (2002). "Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder". Hum. Mol. Genet. 11 (8): 961–9. CiteSeerX 10.1.1.588.1632 . doi: 10.1093/hmg/11.8.961 . PMID 11971877.
Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA (2003). "The Wiskott–Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse". Immunity. 18 (1): 141–54. doi: 10.1016/S1074-7613(02)00516-2 . PMID 12530983.
Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL (2003). "Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (23): 13501–6. Bibcode:2003PNAS..10013501S. doi: 10.1073/pnas.2135380100 . PMC 263843 . PMID 14595024.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Baum W, Kirkin V, Fernández SB, Pick R, Lettau M, Janssen O, Zörnig M (2005). "Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL". J. Biol. Chem. 280 (48): 40012–24. doi: 10.1074/jbc.M502222200 . PMID 16204241.
Yang H, Reinherz EL (2006). "CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST". J. Immunol. 176 (10): 5898–907. doi: 10.4049/jimmunol.176.10.5898 . PMID 16670297.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000140368 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032322 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9857189-5] 1 2 Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (February 1999). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078 . PMID 9857189.

[entrez-6] "Entrez Gene: PSTPIP1 proline-serine-threonine phosphatase interacting protein 1".

[pmid11163214-7] Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA, Goff SP (December 2000). "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation". Mol. Cell. 6 (6): 1413–23. doi: 10.1016/s1097-2765(00)00138-6 . PMID 11163214.

[pmid17353931-8] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

[pmid9422760-9] Dowbenko D, Spencer S, Quan C, Lasky LA (January 1998). "Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein". J. Biol. Chem. 273 (2): 989–96. doi: 10.1074/jbc.273.2.989 . PMID 9422760.

[pmid9265651-10] Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, Simanis V, Lasky LA (August 1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase". J. Cell Biol. 138 (4): 845–60. doi:10.1083/jcb.138.4.845. PMC 2138048 . PMID 9265651.

[pmid9488710-11] Wu Y, Spencer SD, Lasky LA (March 1998). "Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott–Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein". J. Biol. Chem. 273 (10): 5765–70. doi: 10.1074/jbc.273.10.5765 . PMID 9488710.

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PSTPIP1

Contents

Interactions

See also

Related Research Articles

References

Further reading