PUM2

Last updated

PUM2
Protein PUM2 PDB 1ib2.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PUM2 , PUMH2, PUML2, pumilio RNA binding family member 2
External IDs OMIM: 607205; MGI: 1931751; HomoloGene: 69183; GeneCards: PUM2; OMA:PUM2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 2: 20.25 – 20.35 Mb Chr 12: 8.72 – 8.8 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pumilio homolog 2 is an RNA-binding protein that in humans is encoded by the PUM2 gene. [5] [6] [7] [8]

Interactions

PUM2 has been shown to interact with the following proteins:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000055917 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020594 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID   9039502.
  6. Spassov DS, Jurecic R (Dec 2002). "Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins". Gene. 299 (1–2): 195–204. doi:10.1016/S0378-1119(02)01060-0. PMID   12459267.
  7. Moore FL, Jaruzelska J, Fox MS, Urano J, Firpo MT, Turek PJ, Dorfman DM, Pera RA (Jan 2003). "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-Like proteins". Proc Natl Acad Sci U S A. 100 (2): 538–43. Bibcode:2003PNAS..100..538M. doi: 10.1073/pnas.0234478100 . PMC   141031 . PMID   12511597.
  8. "Entrez Gene: PUM2 pumilio homolog 2 (Drosophila)".
  9. Campbell ZT, Menichelli E, Friend K, Wu J, Kimble J, Williamson JR, Wickens M (2012). "Identification of a conserved interface between PUF and CPEB proteins". J Biol Chem. 287 (22): 18854–62. doi: 10.1074/jbc.M112.352815 . PMC   3365739 . PMID   22496444.
  10. Ota R, Kotani T, Yamashita M (2011). "Biochemical characterization of Pumilio1 and Pumilio2 in Xenopus oocytes". J Biol Chem. 286 (4): 2853–63. doi: 10.1074/jbc.M110.155523 . PMC   3024781 . PMID   21098481.
  11. Haston KM, Tung JY, Reijo Pera RA (2009). "Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro". PLOS ONE. 4 (5): e5654. Bibcode:2009PLoSO...4.5654H. doi: 10.1371/journal.pone.0005654 . PMC   2681483 . PMID   19468308.
  12. Geyer CB, Saba R, Kato Y, Anderson AJ, Chappell VK, Saga Y, Eddy EM (2012). "Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male". Biol Reprod. 86 (4): 127. doi:10.1095/biolreprod.111.094938. PMC   3338663 . PMID   22190708.

Further reading