After completing his doctorate, Hsu worked as a principal investigator at the Salk Institute for Biological Studies, where he developed synthetic biology tools for controlling gene expression and cellular behavior.[3] He later joined the faculty at the University of California, Berkeley, where his lab focuses on engineering CRISPR-based technologies for gene editing and therapeutic applications.[4]
Hsu is also a co-founder and director at the Arc Institute, an independent research organization focused on accelerating discoveries in biology and medicine.[5] His work has been recognized for integrating artificial intelligence into genome design, leading to the development of Evo 2, one of the most powerful AI models in biology.[6]
Achievements and recognition
Hsu has received several prestigious awards recognizing his contributions to CRISPR and synthetic biology. He was named to the MIT Technology Review Innovators Under 35 list in 2017 for his pioneering work in genome engineering.[7] He was included in Forbes 30 Under 30 in Science in 2018 for his contributions to CRISPR technology.[8]
Hsu has also been featured in The Economist for discussions on the future of gene editing.[9] His TED Talk on genome engineering has contributed to the public discourse on CRISPR,[10] and his work played a role in CRISPR being named Breakthrough of the Year.
Research
Hsu's research focuses on advancing CRISPR genome-editing technology, improving specificity, efficiency, and therapeutic applications. His work has contributed to:
AI-driven gene editing, where computational models are used to design new gene editors that surpass naturally occurring enzymes.[11]
CRISPR-based RNA-targeting technologies, advancing DNA and RNA editing.[12]
Bridge RNAs for programmable recombination, which allow for precise DNA modifications without traditional genome-editing tools.[13]
"Jumping gene" enzymes, which enable DNA insertion and deletion without using CRISPR, a novel approach published in Nature in 2024.[14]
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