Patrick Lyden

Last updated
  1. 1 2 "Patrick Lyden - Keck School of Medicine of USC".
  2. "Device and method for inducing vascular injury and/or blockage in an animal model".
  3. "Staircase method for optimized therapeutic hypothermia".
  4. 1 2 "Past International Stroke Conference Awardees and Lectors".
  5. "Patrick Lyden - USC Health Sciences Profiles".
  6. "Neurologist Lyden Named Carmen and Louis Warschaw Chair in Neurology During Dedication Ceremony at Cedars-Sinai".
  7. 1 2 "2023 Stroke Council Award Lecturer - Patrick D. Lyden, MD, FAHA".
  8. Lyden, P.; Brott, T.; Tilley, B.; Welch, K. M.; Mascha, E. J.; Levine, S.; Haley, E. C.; Grotta, J.; Marler, J. (1994). "Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group". Stroke. 25 (11): 2220–2226. doi:10.1161/01.str.25.11.2220. PMID   7974549.
  9. 1 2 Lyden, P.; Raman, R.; Liu, L.; Grotta, J.; Broderick, J.; Olson, S.; Shaw, S.; Spilker, J.; Meyer, B.; Emr, M.; Warren, M.; Marler, J. (2005). "NIHSS training and certification using a new digital video disk is reliable". Stroke. 36 (11): 2446–2449. doi:10.1161/01.STR.0000185725.42768.92. PMID   16224093.
  10. "Know the Signs. Act in Time".
  11. Lyden, P. (2017). "Using the National Institutes of Health Stroke Scale: A Cautionary Tale". Stroke. 48 (2): 513–519. doi:10.1161/STROKEAHA.116.015434. PMID   28077454.
  12. National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995). "Tissue plasminogen activator for acute ischemic stroke". The New England Journal of Medicine. 333 (24): 1581–1587. doi:10.1056/NEJM199512143332401. PMID   7477192.
  13. Lyden, P.; Raman, R.; Liu, L.; Emr, M.; Warren, M.; Marler, J. (2009). "National Institutes of Health Stroke Scale certification is reliable across multiple venues". Stroke. 40 (7): 2507–2511. doi:10.1161/STROKEAHA.108.532069. PMC   2726278 . PMID   19520998.
  14. "Generalized efficacy of t-PA for acute stroke. Subgroup analysis of the NINDS t-PA Stroke Trial". Stroke. 28 (11): 2119–2125. 1997. doi:10.1161/01.str.28.11.2119. PMID   9368551.
  15. Lyden, P. D.; Hedges, B. (1992). "Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits". Stroke. 23 (10): 1463–9, discussion 1469-70. doi:10.1161/01.str.23.10.1463. PMID   1357785.
  16. Lyden, P. D.; Jackson-Friedman, C.; Shin, C.; Hassid, S. (2000). "Synergistic combinatorial stroke therapy: A quantal bioassay of a GABA agonist and a glutamate antagonist". Experimental Neurology. 163 (2): 477–489. doi:10.1006/exnr.2000.7394. PMID   10833323.
  17. Lyden, P. D.; Lonzo, L. (1994). "Combination therapy protects ischemic brain in rats. A glutamate antagonist plus a gamma-aminobutyric acid agonist". Stroke. 25 (1): 189–196. doi:10.1161/01.str.25.1.189. PMID   7903492.
  18. Shuaib, Ashfaq; Lees, Kennedy R.; Lyden, Patrick; Grotta, James; Davalos, Antonio; Davis, Stephen M.; Diener, Hans-Christoph; Ashwood, Tim; Wasiewski, Warren W.; Emeribe, Ugochi; SAINT II Trial Investigators (2007). "NXY-059 for the Treatment of Acute Ischemic Stroke". New England Journal of Medicine. 357 (6): 562–571. doi:10.1056/NEJMoa070240. PMID   17687131.
  19. Chen, B.; Friedman, B.; Cheng, Q.; Tsai, P.; Schim, E.; Kleinfeld, D.; Lyden, P. D. (2009). "Severe blood-brain barrier disruption and surrounding tissue injury". Stroke. 40 (12): e666-74. doi:10.1161/STROKEAHA.109.551341. PMC   2819286 . PMID   19893002.
  20. Friedman, B.; Schachtrup, C.; Tsai, P. S.; Shih, A. Y.; Akassoglou, K.; Kleinfeld, D.; Lyden, P. D. (2009). "Acute vascular disruption and aquaporin 4 loss after stroke". Stroke. 40 (6): 2182–2190. doi:10.1161/STROKEAHA.108.523720. PMC   2753985 . PMID   19372455.
  21. Manoonkitiwongsa, P. S.; Jackson-Friedman, C.; McMillan, P. J.; Schultz, R. L.; Lyden, P. D. (2001). "Angiogenesis after stroke is correlated with increased numbers of macrophages: the clean-up hypothesis". Journal of Cerebral Blood Flow and Metabolism. 21 (10): 1223–1231. doi:10.1097/00004647-200110000-00011. PMID   11598500.
  22. Yu, S. W.; Friedman, B.; Cheng, Q.; Lyden, P. D. (2007). "Stroke-evoked angiogenesis results in a transient population of microvessels". Journal of Cerebral Blood Flow and Metabolism. 27 (4): 755–763. doi:10.1038/sj.jcbfm.9600378. PMID   16883352.
  23. Lyden, P.; Pereira, B.; Chen, B.; Zhao, L.; Lamb, J.; Lei, I. F.; Rajput, P. (2014). "Direct thrombin inhibitor argatroban reduces stroke damage in 2 different models". Stroke. 45 (3): 896–899. doi:10.1161/STROKEAHA.113.004488. PMC   3995814 . PMID   24473182.
  24. Rajput, P. S.; Lyden, P. D.; Chen, B.; Lamb, J. A.; Pereira, B.; Lamb, A.; Zhao, L.; Lei, I. F.; Bai, J. (2014). "Protease Activated Receptor-1 mediates cytotoxicity during ischemia using in vivo and in vitro models". Neuroscience. 281: 229–240. doi:10.1016/j.neuroscience.2014.09.038. PMC   4377119 . PMID   25261684.
  25. Rajput, P. S.; Lamb, J.; Kothari, S.; Pereira, B.; Soetkamp, D.; Wang, Y.; Tang, J.; Van Eyk, J. E.; Mullins, E. S.; Lyden, P. D. (2020). "Neuron-generated thrombin induces a protective astrocyte response via protease activated receptors". Glia. 68 (2): 246–262. doi:10.1002/glia.23714. PMC   7391964 . PMID   31453648.
  26. Lyden, P. D.; Lamb, J.; Kothari, S.; Toossi, S.; Boitano, P.; Rajput, P. S. (2019). "Differential effects of hypothermia on neurovascular unit determine protective or toxic results: Toward optimized therapeutic hypothermia". Journal of Cerebral Blood Flow and Metabolism. 39 (9): 1693–1709. doi:10.1177/0271678X18814614. PMC   6727141 . PMID   30461327.
  27. Rajput, P. S.; Lamb, J. A.; Bai, J.; Pereira, B. R.; Lei, I. F.; Leung, J.; Griffin, J. H.; Lyden, P. D.; Lyden, Patrick D. (2019). "Neuroprotection and vascular protection using genetically targeted protease-ligands". Brain Research. 1715: 13–20. doi:10.1016/j.brainres.2019.03.010. PMC   6500472 . PMID   30880117.
  28. Rajput, P.; Brookshier, A.; Kothari, S.; Eckstein, L.; Chang, H.; Liska, S.; Lamb, J.; Sances, S.; Lyden, P. (2024). "Differential Vulnerability and Response to Injury among Brain Cell Types Comprising the Neurovascular Unit". The Journal of Neuroscience. 44 (22): e1093222024. doi:10.1523/JNEUROSCI.1093-22.2024. PMC   11140689 . PMID   38548341.
  29. Lyden, P.; Buchan, A.; Boltze, J.; Fisher, M.; STAIR XI Consortium (2021). "Cerebroprotection for Acute Ischemic Stroke: Looking Ahead". Stroke. 52 (9): 3063–3071. doi:10.1161/STROKEAHA.121.034947. PMC   8384700 . PMID   34289707.
  30. Lyden, P. D. (2021). "Cerebroprotection for Acute Ischemic Stroke: Looking Ahead". Stroke. 52 (9): 3033–3044. doi:10.1161/STROKEAHA.121.032241. PMC   8384682 . PMID   34289710.
  31. Lyden, P. D.; et al. (2022). "The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results". Stroke. 53 (5): 1802–1812. doi:10.1161/STROKEAHA.121.038047. PMC   9038686 . PMID   35354299.
  32. Lyden, P. D.; et al. (2023). "A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke". Science Translational Medicine. 15 (714): eadg8656. doi:10.1126/scitranslmed.adg8656. PMID   37729432.
  33. "Brain & Brain PET 2023" (PDF).
Patrick D. Lyden
Born
Nationality American
Title Professor of Physiology and Neuroscience
Academic background
Education B.S., Biochemistry
M.D., Medicine
Alma mater University of California, Los Angeles
Medicine, Baylor College of Medicine