Paul Thomas Sharpe (born 12 December 1955) is a British biologist,currently serving as the Dickinson Professor of Craniofacial Biology and the Director of the Centre for Craniofacial and Regenerative Biology,King's College London.[1]
Following his doctoral work at the University of Sheffield,Sharpe continued as a postdoctoral researcher there and also at the University of Wisconsin and the University of Cambridge prior to his first academic appointment at the University of Manchester (1997). Sharpe's research focuses on cell differentiation and began with his doctoral work on differentiation of the cellular slime mould Dictyostelium discoideum but he extended this work to mammalian tissues,principally bone.[2][3] In this early work he applied the technique of thin layer countercurrent distribution.[4][5] Subsequently,through the study of mouse embryo differentiation and the role of homeobox sequences in DNA,his work has mainly been applied to the field of craniofacial development.[6][7] Most recently he has been leading research into the possibility of tooth regeneration and the development of new biological-based treatments for tooth repair.[8][9][10][11][12] Sharpe is author of Methods of Cell Separation.[13]
Sharpe has over 300 publications listed on Web of Science which have been cited more than 14,500 times;his h-index is 66. His three most-cited articles are:
Tucker, A; Sharpe, P (2004). "The cutting-edge of mammalian development; how the embryo makes teeth". Nature Reviews Genetics. 5 (7): 499–508. doi:10.1038/nrg1380. PMID15211352. S2CID42067451.
↑ Sharpe, PT; Treffry, TE; Watts, DJ (1982). "Studies of early stages of differentiation of the cellular slime mould Dictyostelium discoideum". Development. 67: 181–193. doi:10.1242/dev.67.1.181.
↑ Sharpe, PT; Gallagher, JA; Treffry, TE; Russell, RGG (1982). "Studies of the growth of human bone-derived cells in culture using aqueous two-phase partition". Bioscience Reports. 4 (5): 415–419. doi:10.1007/BF01122506. PMID6203567. S2CID46613754.
↑ Sharpe, PT; Watts, DJ (1985). "Use of aqueous two-phase partition to detect cell surface changes during growth of D. discoideum". J. Cell Sci. 75: 339–346. doi:10.1242/jcs.75.1.339. PMID4044679.
↑ Gaunt, SJ; Sharpe, PT; Duboule, D (1988). "Spatially-restricted domains of homeo-gene transcripts in mouse embryos: relation to a segmented body plan". Development. 104: 169–181. doi:10.1242/dev.104.Supplement.169.
↑ Gaunt, SJ; Coletta, PL; Sharpe, PT (1988). "Mouse Hox- 3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network". Development. 109 (2): 329–341. doi:10.1242/dev.109.2.329. PMID1976088.
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