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Peter Henry St George-Hyslop, OC, FRS, FRSC, FRCPC, (born July 10, 1953) is a British and Canadian medical scientist, neurologist and molecular geneticist who is known for his research into neurodegenerative diseases. St George-Hyslop is one of the most cited authors in the field of Alzheimer's disease research. [1] He has identified a number of key genes that are responsible for nerve cell degeneration and early-onset forms of Alzheimer's disease. These include the discovery of the presenilins (PSEN1 and PSEN2), Nicastrin, and SORL1 genes. [2] Presenilin mutations are the most common cause of familial Alzheimer's disease. [3] St George-Hyslop also co-led the discovery of the gene for the amyloid precursor protein. [2]
St George-Hyslop's father, Noel St George Hyslop was a renowned scientist who worked on Foot and Mouth Disease virus.
Since 2007 St George-Hyslop has headed an Alzheimer's disease research program as Professor of Experimental Neuroscience at the University of Cambridge. [4] [5]
Educated at Wellington School, Wellington, Somerset, UK, St George-Hyslop completed his medical training in Canada, graduating with the MD degree in 1976, and then pursuing post-doctoral research in internal medicine and neurology at the University of Toronto and Harvard Medical School. He served his first appointment at Harvard's Massachusetts General Hospital, where he taught molecular genetics and neurology from 1987 to 1991. He was appointed to the University of Toronto in 1991, and since 2003 has held the university's highest rank of University Professor. From 1995 to 2018, St George-Hyslop served as the director of the Tanz Centre for Research in Neurodegenerative Diseases at the University of Toronto Faculty of Medicine. [6] [7] In 2007 St George-Hyslop was appointed Professor of Experimental Neuroscience at the University of Cambridge.
He was awarded the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 1987, [8] the Howard Hughes Medical Institute International Scholar Award in 1997 and 2002, the Gold Medal in Medicine from the Royal College of Physicians of Canada in 1994, the Michael Smith Award from the Canadian Institutes of Health Research in 1997 and the Dan David Prize in 2014. [9] He is a member of the American Society for Clinical Investigation, a fellow of the Royal Society of London and the Royal Society of Canada, and a Foreign Member to the Institute of Medicine of the United States National Academies. He was appointed Officer of the Order of Canada in 2018. [10]
The Alzheimer Society of Ontario (ASO) is a care and research charity committed to helping people living with Alzheimer's disease and other dementias by:
Christine Van Broeckhoven is a Belgian molecular biologist and professor in Molecular genetics at the University of Antwerp. She is also leading the VIB Department of Molecular Genetics, University of Antwerp of the Flanders Institute for Biotechnology (VIB). Christine Van Broeckhoven does research on Alzheimer dementia, bipolar mental disorders and other neurological diseases. Since 1983 she has had her own laboratory for molecular genetics at the University of Antwerp, and since 2005 is focussing her research on neurodegenerative brain diseases. She is an associate editor of the scientific journal Genes, Brain and Behavior.
Sir John Anthony Hardy is a human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at University College London with research interests in neurological diseases.
Nicastrin, also known as NCSTN, is a protein that in humans is encoded by the NCSTN gene.
Bart De Strooper is a Belgian molecular biologist and professor at Vlaams Instituut voor Biotechnologie and KU Leuven and the UK Dementia Research Institute and University College London, UK. De Strooper's research seeks to translate genetic data into the identification and tratment of neurodegenerative diseases and treatments. interest are the secretases, proteases which cleave the amyloid precursor protein (APP), resulting in amyloid peptides.
Presenilin-2 is a protein that is encoded by the PSEN2 gene.
John Quinn Trojanowski was an American academic research neuroscientist specializing in neurodegeneration. He and his partner, Virginia Man-Yee Lee, MBA, Ph.D., are noted for identifying the roles of three proteins in neurodegenerative diseases: tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease, and TDP-43 in Amyotrophic Lateral Sclerosis (ALS) and frontotemporal degeneration.
The National Core for Neuroethics at the University of British Columbia was established in August 2007, with support from the Canadian Institutes of Health Research, the Institute of Mental Health and Addiction, the Canada Foundation for Innovation, the British Columbia Knowledge Development Fund, the Canada Research Chairs program, the UBC Brain Research Centre and the UBC Institute of Mental Health. Co-founded by Judy Illes and Peter Reiner, the Core studies neuroethics, with particular focus on ethics in neurodegenerative disease and regenerative medicine, international and cross-cultural challenges in brain research, neuroimaging and ethics, the neuroethics of enhancement, and personalized medicine.
Anne Buckingham Young is an American physician and neuroscientist who has made major contributions to the study of neurodegenerative diseases, with a focus on movement disorders like Huntington's disease and Parkinson's disease. Young completed her undergraduate studies at Vassar College and earned a dual MD/PhD from Johns Hopkins Medical School. She has held faculty positions at University of Michigan and Harvard University. She became the first female chief of service at Massachusetts General Hospital when she was appointed Chief of Neurology in 1991. She retired from this role and from clinical service in 2012. She is a member of many academic societies and has won numerous awards. Young is also the only person to have been president of both the international Society for Neuroscience and the American Neurological Association.
Lt.-Col. Noel St George Hyslop, TD was a British physician, veterinary surgeon and public health officer.
Graham Leon Collingridge is a British neuroscientist and professor at the University of Toronto and at the University of Bristol. He is also a senior investigator at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital in Toronto.
Ryman Healthcare Limited is a New Zealand retirement village and rest home operator. It is listed on the New Zealand Stock Exchange and is one of the largest companies listed on the NZX 50 Index.
Sir Michael John Owen FRCPsych FMedSci FLSW is a Welsh research scientist in the area of psychiatry, currently the head of the Division of Psychological Medicine and Clinical Neurosciences at Cardiff University.
The Krembil Research Institute, formerly known as the Toronto Western Research Institute, is an academic medical research institute in Toronto. It is one of the largest research institutes in Canada focusing on human neurological disease.
Bryce Vissel is an Australian neuroscientist who is a professor of neuroscience at the University of New South Wales. He is the Director of the Centre for Neuroscience and Regenerative Medicine (CNRM) at St Vincent's Hospital Sydney. He is a specialist in neurodegenerative diseases, such as Alzheimer's, Parkinson's, and the neural basis of learning, memory and movement.
Donald L. Price (1935-2023) was an American neuropathologist and professor at the Johns Hopkins School of Medicine. His research aimed to understand the molecular basis of neurodegenerative diseases, particularly Alzheimer’s disease. Price received a number of awards for his work and served as the President of both the American Association of Neuropathologists and the Society for Neuroscience.
Rosa Rademakers is an American neurogeneticist and professor within the Department of Neuroscience at the Mayo Clinic. Her research centers on the genetic basis of neurodegenerative diseases, such as identifying causal genes and their function, exploring familial risk factors, and the mechanism of the degeneration. Her neurodegenerative diseases of focus include "Alzheimer's disease (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS)." She received a Bachelor of Arts in Biology, a Master of Arts in Biochemistry, and a Ph.D. in Science, all from the University of Antwerp. Originally from the Netherlands, she came to the Mayo Clinic in 2005 for a post-doctoral fellowship, and in 2007 she was given a lab director position.
Dennis J. Selkoe is an American physician (neurologist) known for his research into the molecular basis of Alzheimer's disease. In 1985 he became Co-Director of the Center for Neurological Diseases and from 1990, Vincent and Stella Coates Professor of Neurological Diseases at Harvard Medical School. He is also a Fellow of the AAAS and a member of the National Academy of Medicine.
Catarina Resende de Oliveira is a Portuguese neurologist, researcher, university professor, and doctor. A full professor of biochemistry at the Faculty of Medicine of the University of Coimbra, she studies the processes that cause neurological degeneration responsible for illnesses such as Alzheimer's disease and Parkinson's disease.
Gerard David Schellenberg is an academic neuropathologist who specializes in the research of Alzheimer's disease. He is the director of Penn Neurodegeneration Genomics Center as well as a professor of Pathology and Laboratory Medicine at the University of Pennsylvania. He is a leading contributor to Alzheimer's disease research.