Phosducin-like

PDCL
Identifiers
Aliases	PDCL , PhLP, Phosducin-like, phosducin like
External IDs	OMIM: 604421 MGI: 1914716 HomoloGene: 38043 GeneCards: PDCL
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q33.2 Start 122,798,389 bp [1] End 122,828,588 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 37,240,086 bp [2] End 37,249,344 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell visceral pleura oocyte parietal pleura tibia Achilles tendon secondary oocyte germinal epithelium cavity of mouth ganglionic eminence Top expressed in pineal gland cumulus cell medial ganglionic eminence stria vascularis carotid body superior cervical ganglion maxillary prominence seminal vesicula left lung lobe retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding queuine tRNA-ribosyltransferase activity protein-containing complex binding Cellular component cytoplasm cytosol cilium cell projection Biological process queuosine biosynthetic process heterotrimeric G-protein complex assembly regulation of G protein-coupled receptor signaling pathway negative regulation of protein refolding signal transduction visual perception response to stimulus protein folding positive regulation of smoothened signaling pathway cell projection organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5082 67466 Ensembl ENSG00000136940 ENSMUSG00000009030 UniProt Q13371 Q9DBX2 RefSeq (mRNA) NM_005388 NM_026176 RefSeq (protein) NP_005379 NP_080452 Location (UCSC) Chr 9: 122.8 – 122.83 Mb Chr 2: 37.24 – 37.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosducin-like protein is a protein that in humans is encoded by the PDCL gene. ^{[5] [6]}

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in the retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000136940 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009030 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Thibault C, Feng Wang J, Charnas R, Mirel D, Barhite S, Miles MF (May 1999). "Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization". Biochim Biophys Acta. 1444 (3): 346–54. doi:10.1016/S0167-4781(99)00006-8. PMID   10095058.
6. "Entrez Gene: PDCL phosducin-like".

Further reading

• Miles MF, Barhite S, Sganga M, Elliott M (1993). "Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10831–5. Bibcode:1993PNAS...9010831M. doi: 10.1073/pnas.90.22.10831 . PMC   47872 . PMID   8248177.
• Lazarov ME, Martin MM, Willardson BM, Elton TS (1999). "Human phosducin-like protein (hPhLP) messenger RNA stability is regulated by cis-acting instability elements present in the 3'-untranslated region". Biochim. Biophys. Acta. 1446 (3): 253–64. doi:10.1016/S0167-4781(99)00098-6. PMID   10524200.
• Ruiz-Gómez A, Humrich J, Murga C, et al. (2000). "Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2". J. Biol. Chem. 275 (38): 29724–30. doi: 10.1074/jbc.M001864200 . PMID   10884381.
• Lazarov ME, Martin MM, Willardson BM, Elton TS (2000). "Molecular cloning and characterization of the human phosducin-like protein (hPhLP) promoter". Biochim. Biophys. Acta. 1492 (2–3): 460–4. doi:10.1016/S0167-4781(00)00137-8. PMID   10899582.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• McLaughlin JN, Thulin CD, Hart SJ, et al. (2002). "Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7962–7. Bibcode:2002PNAS...99.7962M. doi: 10.1073/pnas.112075699 . PMC   123003 . PMID   12060742.
• Humrich J, Bermel C, Grubel T, et al. (2003). "Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing". J. Biol. Chem. 278 (7): 4474–81. doi: 10.1074/jbc.M206347200 . PMID   12466282.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Carter MD, Southwick K, Lukov G, et al. (2005). "Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry". J Biomol Tech. 15 (4): 257–64. PMC   2291704 . PMID   15585822.
• Humrich J, Bermel C, Bünemann M, et al. (2005). "Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding". J. Biol. Chem. 280 (20): 20042–50. doi: 10.1074/jbc.M409233200 . PMID   15745879.
• Lukov GL, Hu T, McLaughlin JN, et al. (2005). "Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly". EMBO J. 24 (11): 1965–75. doi:10.1038/sj.emboj.7600673. PMC   1142607 . PMID   15889144.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Lukov GL, Baker CM, Ludtke PJ, et al. (2006). "Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex". J. Biol. Chem. 281 (31): 22261–74. doi: 10.1074/jbc.M601590200 . PMID   16717095.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.