Phospholipase A2 group IVD

PLA2G4D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IXC, 5IZR, 5IZ5
Identifiers
Aliases	PLA2G4D , cPLA2delta, phospholipase A2 group IVD
External IDs	OMIM: 612864; MGI: 1925640; HomoloGene: 52252; GeneCards: PLA2G4D; OMA:PLA2G4D - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q15.1 Start 42,067,009 bp [1] End 42,094,562 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E5 Start 120,096,076 bp [2] End 120,119,678 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg gonad testicle vagina pituitary gland anterior pituitary prostate ectocervix endometrium Top expressed in esophagus primary oocyte placenta secondary oocyte decidua spermatid embryo lumbar subsegment of spinal cord zygote seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function phospholipase activity metal ion binding hydrolase activity phospholipase A1 activity lysophospholipase activity phospholipase A2 activity calcium-dependent phospholipase A2 activity calcium ion binding calcium-dependent phospholipid binding Cellular component cytoplasm cytosol membrane Biological process phosphatidic acid biosynthetic process phosphatidylserine acyl-chain remodeling phosphatidylethanolamine acyl-chain remodeling lipid metabolism phosphatidylinositol acyl-chain remodeling lipid catabolic process phosphatidylglycerol acyl-chain remodeling phospholipid catabolic process phospholipid metabolic process metabolism phosphatidylcholine acyl-chain remodeling glycerophospholipid catabolic process fatty acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283748 78390 Ensembl ENSG00000159337 ENSMUSG00000070719 UniProt Q86XP0 Q50L43 RefSeq (mRNA) NM_178034 NM_001024137 RefSeq (protein) NP_828848 NP_001019308 Location (UCSC) Chr 15: 42.07 – 42.09 Mb Chr 2: 120.1 – 120.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phospholipase A2 group IVD is a protein that in humans is encoded by the PLA2G4D gene. ^[5]

Function

The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000159337 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070719 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Phospholipase A2 group IVD" . Retrieved 2017-09-13.
6. Chiba, H; Michibata, H; Wakimoto, K; Seishima, M; Kawasaki, S; Okubo, K; Mitsui, H; Torii, H; Imai, Y (2004). "Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin". Journal of Biological Chemistry. 279 (13): 12890–7. doi: 10.1074/jbc.M305801200 . PMID   14709560.

Further reading

• Chiba H, Michibata H, Wakimoto K, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y (2004). "Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin". J. Biol. Chem. 279 (13): 12890–7. doi: 10.1074/jbc.M305801200 . PMID   14709560.
• Tao R, Yu Y, Zhang X, Shi J, Guo Y, Wang C, Han B, Xu Q, Shang H, Zhang X, Xie L, Liu S, Ju G, Shen Y, Wei J (2005). "A family based study of the genetic association between the PLA2G4D gene and schizophrenia". Prostaglandins Leukot. Essent. Fatty Acids. 73 (6): 419–22. doi:10.1016/j.plefa.2005.08.008. PMID   16213696.
• Yu Q, Shi JP, Kou CG, Meng XF, Yu YQ (2008). "[Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia]". Zhonghua Liu Xing Bing Xue Za Zhi (in Chinese). 29 (2): 173–6. PMID   18686860.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC   2775832 . PMID   19913121.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC   2945168 . PMID   20628086.
• Parry M, Rose-Zerilli MJ, Gibson J, Ennis S, Walewska R, Forster J, Parker H, Davis Z, Gardiner A, Collins A, Oscier DG, Strefford JC (2013). "Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma". PLOS ONE. 8 (12) e83244. Bibcode:2013PLoSO...883244P. doi: 10.1371/journal.pone.0083244 . PMC   3862727 . PMID   24349473.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.