Polyamine-modulated factor 1

PMF1
Identifiers
Aliases	PMF1 , polyamine modulated factor 1
External IDs	OMIM: 609176; MGI: 1914287; HomoloGene: 5224; GeneCards: PMF1; OMA:PMF1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q22 Start 156,212,993 bp [1] End 156,240,042 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 88,301,450 bp [2] End 88,317,638 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh apex of heart right lobe of thyroid gland left lobe of thyroid gland gastrocnemius muscle right auricle of heart ectocervix skin of leg left ventricle granulocyte Top expressed in yolk sac embryo embryo ventricular zone tibiofemoral joint blastocyst internal carotid artery lip morula epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity leucine zipper domain binding protein binding Cellular component chromosome cytosol MIS12/MIND type complex chromosome, centromeric region nucleus kinetochore transcription regulator complex nucleoplasm Golgi apparatus intracellular membrane-bounded organelle nuclear MIS12/MIND complex Biological process chromosome segregation cell division cell cycle regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11243 67037 Ensembl ENSG00000160783 ENSMUSG00000028066 UniProt Q6P1K2 Q9CPV5 RefSeq (mRNA) NM_007221 NM_001199653 NM_001199654 NM_025928 NM_001310605 RefSeq (protein) NP_001186582 NP_001186583 NP_009152 NP_001297534 NP_080204 Location (UCSC) Chr 1: 156.21 – 156.24 Mb Chr 3: 88.3 – 88.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene. ^{[5] [6]}

Interactions

Polyamine-modulated factor 1 has been shown to interact with MIS12. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000160783 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028066 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang Y, Devereux W, Stewart TM, Casero RA (July 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". The Journal of Biological Chemistry. 274 (31): 22095–101. doi: 10.1074/jbc.274.31.22095 . PMID   10419538.
6. "Entrez Gene: PMF1 polyamine-modulated factor 1".
7. Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC   517519 . PMID   15371340.
8. Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID   15502821. S2CID   39408000.

Further reading

• Wang Y, Devereux W, Stewart TM, Casero RA (April 2001). "Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene". The Biochemical Journal. 355 (Pt 1): 45–9. doi:10.1042/0264-6021:3550045. PMC   1221710 . PMID   11256947.
• Wang Y, Devereux W, Stewart TM, Casero RA (August 2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". The Biochemical Journal. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC   1222765 . PMID   12020345.
• Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC   517519 . PMID   15371340.
• Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID   15502821. S2CID   39408000.
• Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A (April 2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". The Journal of Cell Biology. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC   2063780 . PMID   16585270.