MIS12

MIS12
Identifiers
Aliases	MIS12 , 2510025F08Rik, KNTC2AP, MTW1, hMis12, kinetochore complex component, MIS12 kinetochore complex component
External IDs	OMIM: 609178 MGI: 1914389 HomoloGene: 11429 GeneCards: MIS12
Gene location (Human)
Chr.	Chromosome 17 (human)
End	5,490,814 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,918,197 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; germinal epithelium; ; parietal pleura; ; bronchial epithelial cell; ; visceral pleura; ; tibia; ; superficial temporal artery; ; palpebral conjunctiva; ; caput epididymis; ; appendix;
	Top expressed in
	otic placode; ; saccule; ; maxillary prominence; ; hand; ; secondary oocyte; ; yolk sac; ; superior cervical ganglion; ; somite; ; thymus; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	chromosome ; cytosol ; MIS12/MIND type complex ; chromosome, centromeric region ; nucleus ; kinetochore ; nuclear MIS12/MIND complex ;
Biological process	chromosome segregation ; cell division ; cell cycle ; kinetochore assembly ; attachment of mitotic spindle microtubules to kinetochore ; mitotic cell cycle ; protein localization to kinetochore ; mitotic sister chromatid segregation ;
	Sources:Amigo / QuickGO
Orthologs
	79003
	67139
	ENSG00000167842
	ENSMUSG00000040599
	Q9H081
	Q9CY25
	NM_001258217 ; NM_001258218 ; NM_001258219 ; NM_001258220 ; NM_024039 Contents Interactions ; References ; Further reading ;
	NM_025993
	NP_001245146 ; NP_001245147 ; NP_001245148 ; NP_001245149 ; NP_076944
	NP_080269
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.^[5]^[6]^[7]

Interactions

MIS12 has been shown to interact with NSL1,^[8] ZWINT,^[8]^[9] CASC5,^[8]^[9] Polyamine-modulated factor 1,^[8]^[9] NDC80,^[8]^[9] DSN1 ^[8]^[9] and CBX5.^[8]

Related Research Articles

Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.

Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.

Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.

Centromere protein U is a protein that in humans is encoded by the CENPU gene.

Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.

COP9 signalosome complex subunit 7a is a protein that in humans is encoded by the COPS7A gene.

Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.

ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene.

Nucleoporin 160 (Nup160) is a protein that in humans is encoded by the NUP160 gene.

Centromere protein H is a protein that in humans is encoded by the CENPH gene.

Centromere protein I is a protein that in humans is encoded by the CENPI gene.

Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene. It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called HP1α. Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins.

KNL1 is a protein that is encoded by the KNL1 gene in humans.

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.

DSN1, MIND kinetochore complex component, homolog , also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene.

Centromere protein L is a protein that in humans is encoded by the CENPL gene.

Iain Cheeseman investigates the role of the kinetochore, a group of proteins required for cell division and chromosome segregation. This core network of proteins facilitates the attachment of chromosomes to microtubule polymers—the spindle structures that attach to the ends of cells, pulling and dividing them during cell division. The kinetochore is critical to ensuring duplication without loss or damage to the genetic material. Cheeseman is also investigating the activities of the individual molecular machines that make up this structure and how these proteins are controlled and regulated.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167842 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040599 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
↑ Goshima G, Kiyomitsu T, Yoda K, Yanagida M (Jan 2003). "Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway". J Cell Biol. 160 (1): 25–39. doi:10.1083/jcb.200210005. PMC 2172742 . PMID 12515822.
↑ "Entrez Gene: MIS12 MIS12, MIND kinetochore complex component, homolog (yeast)".
1 2 3 4 5 6 7 Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. England. 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821. S2CID 39408000.
1 2 3 4 5 Cheeseman, Iain M; Niessen Sherry; Anderson Scott; Hyndman Francie; Yates John R; Oegema Karen; Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. United States. 18 (18): 2255–68. doi:10.1101/gad.1234104. ISSN 0890-9369. PMC 517519 . PMID 15371340.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Cheeseman IM, Niessen S, Anderson S, et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519 . PMID 15371340.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Obuse C, Iwasaki O, Kiyomitsu T, et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Kline SL, Cheeseman IM, Hori T, et al. (2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". J. Cell Biol. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780 . PMID 16585270.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167842 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040599 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.

[pmid12515822-6] Goshima G, Kiyomitsu T, Yoda K, Yanagida M (Jan 2003). "Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway". J Cell Biol. 160 (1): 25–39. doi:10.1083/jcb.200210005. PMC 2172742 . PMID 12515822.

[entrez-7] "Entrez Gene: MIS12 MIS12, MIND kinetochore complex component, homolog (yeast)".

[pmid15502821-8] 1 2 3 4 5 6 7 Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. England. 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821. S2CID 39408000.

[pmid15371340-9] 1 2 3 4 5 Cheeseman, Iain M; Niessen Sherry; Anderson Scott; Hyndman Francie; Yates John R; Oegema Karen; Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. United States. 18 (18): 2255–68. doi:10.1101/gad.1234104. ISSN 0890-9369. PMC 517519 . PMID 15371340.

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MIS12

Contents

Interactions

Related Research Articles

References

Further reading