| ZWINT | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ZWINT , HZwint-1, KNTC2AP, ZWINT1, SIP30, ZW10 interacting kinetochore protein | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609177 MGI: 1289227 HomoloGene: 48496 GeneCards: ZWINT | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene. [5]
Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [5]
ZWINT has been shown to interact with MIS12. [6] [7] ZWINT has also been shown to interact with RAB3C [8]
A kinetochore is a disc-shaped protein structure associated with duplicated chromatids in eukaryotic cells where the spindle fibers attach during cell division to pull sister chromatids apart. The kinetochore assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis. The term kinetochore was first used in a footnote in a 1934 Cytology book by Lester W. Sharp and commonly accepted in 1936. Sharp's footnote reads: "The convenient term kinetochore has been suggested to the author by J. A. Moore", likely referring to John Alexander Moore who had joined Columbia University as a freshman in 1932.
Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 is an enzyme that in humans is encoded by the BUB1 gene.
Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.
Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.
Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.
Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.
COP9 signalosome complex subunit 7a is a protein that in humans is encoded by the COPS7A gene.
Centromere protein H is a protein that in humans is encoded by the CENPH gene. It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.
Centromere protein I is a protein that in humans is encoded by the CENPI gene.
Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene. It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called HP1α. Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins.
KNL1 is a protein that is encoded by the KNL1 gene in humans.
Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.
Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.
Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.
Kinetochore protein Spc24 is a protein that in humans is encoded by the SPC24 gene.
Centromere protein K is a protein that in humans is encoded by the CENPK gene.
DSN1, MIND kinetochore complex component, homolog , also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene.
Ras-related protein Rab-3C is a protein that in humans is encoded by the RAB3C gene.
Iain Cheeseman investigates the role of the kinetochore, a group of proteins required for cell division and chromosome segregation. This core network of proteins facilitates the attachment of chromosomes to microtubule polymers—the spindle structures that attach to the ends of cells, pulling and dividing them during cell division. The kinetochore is critical to ensuring duplication without loss or damage to the genetic material. Cheeseman is also investigating the activities of the individual molecular machines that make up this structure and how these proteins are controlled and regulated.
MIS18 binding protein 1 is a protein that in humans is encoded by the MIS18BP1 gene. The gene is also known as LKNL2, M18BP1, C14orf106, and HSA242977.
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