RAB3C

RAB3C
Identifiers
Aliases	RAB3C , member RAS oncogene family
External IDs	OMIM: 612829 MGI: 1914545 HomoloGene: 23420 GeneCards: RAB3C
Gene location (Human)
Chr.	Chromosome 5 (human)
End	58,859,394 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	110,417,530 bp
RNA expression pattern
	Top expressed in
	Brodmann area 46; ; middle temporal gyrus; ; superior frontal gyrus; ; Brodmann area 23; ; superior vestibular nucleus; ; islet of Langerhans; ; postcentral gyrus; ; prefrontal cortex; ; pons; ; external globus pallidus;
	Top expressed in
	medial dorsal nucleus; ; ventral tegmental area; ; medial geniculate nucleus; ; subiculum; ; lateral geniculate nucleus; ; superior colliculus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; dorsal tegmental nucleus; ; inferior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; myosin V binding ; protein binding ; GTP-dependent protein binding ; GTPase activity ;
Cellular component	perinuclear region of cytoplasm ; vesicle ; cytosol ; plasma membrane ; membrane ; synaptic vesicle ; anchored component of synaptic vesicle membrane ; endosome ;
Biological process	regulation of exocytosis ; protein transport ; antigen processing and presentation ; intracellular protein transport ; vesicle docking involved in exocytosis ; protein secretion ; Rab protein signal transduction ; protein localization to plasma membrane ;
	Sources:Amigo / QuickGO
Orthologs
	115827
	67295
	ENSG00000152932
	ENSMUSG00000021700
	Q96E17
	P62823
	NM_138453 ; NM_001317915
	NM_023852 ; NM_001360099
	NP_001304844 ; NP_612462
	NP_076341 ; NP_001347028
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 17, 2024

Ras-related protein Rab-3C is a protein that in humans is encoded by the RAB3C gene.^[5]^[6]

Interactions

Rab3C has been shown to interact with ZWINT.^[7]

Related Research Articles

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Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene.

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered exocytosis in neurons.

Ras-related protein Rab-4A is a protein that in humans is encoded by the RAB4A gene.

RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.

Rabphilin-3A is a protein that in humans is encoded by the RPH3A gene. It contains two C2 domains and binds calcium ions at low micromolar concentration. Rabphilin was shown to regulate neurotransmitter release in hippocampal neurons after neurons had an increased synaptic activity and their release rate was depressed.

Ras-related protein Rab-3B is a protein that in humans is encoded by the RAB3B gene.

Regulating synaptic membrane exocytosis protein 2 is a protein that in humans is encoded by the RIMS2 gene.

Rab3 GTPase-activating protein catalytic subunit is an enzyme that in humans is encoded by the RAB3GAP1 gene.

Rab effector Noc2 is a protein that in humans is encoded by the RPH3AL gene.

Ras-related protein Rab-3D is a protein that in humans is encoded by the RAB3D gene.

ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene.

Ras-related protein Rab-10 is a protein that in humans is encoded by the RAB10 gene.

Ras-related protein Rab-40A is a protein that in humans is encoded by the RAB40A gene.

Ras-related protein Rab-15 is a protein that in humans is encoded by the RAB15 gene.

Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.

Ras-related protein Rab-26 is a protein that in humans is encoded by the RAB26 gene.

Ras-related protein Rab-37 is a protein that in humans is encoded by the RAB37 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152932 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021700 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Cheng H, Ma Y, Ni X, Jiang M, Luo Y, Ying K, Xie Y, Ma Y (Aug 2002). "Cloning, mapping, and characterization of the human Rab3C gene". Biochemical Genetics. 40 (7–8): 263–72. doi:10.1023/A:1019834901190. PMID 12296628. S2CID 10653465.
↑ "Entrez Gene: RAB3C RAB3C, member RAS oncogene family".
↑ van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters. 582 (19): 2838–42. doi: 10.1016/j.febslet.2008.07.012 . PMID 18625232. S2CID 30206840.

Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (Jun 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi: 10.1073/pnas.0306709101 . PMC 420391 . PMID 15159548.
Fukuda M (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi: 10.1074/jbc.M212341200 . PMID 12578829.
Schlüter OM, Khvotchev M, Jahn R, Südhof TC (Oct 2002). "Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion". The Journal of Biological Chemistry. 277 (43): 40919–29. doi: 10.1074/jbc.M203704200 . PMID 12167638.
Uphues I, Chern Y, Eckel J (Dec 1995). "Insulin-dependent translocation of the small GTP-binding protein rab3C in cardiac muscle: studies on insulin-resistant Zucker rats". FEBS Letters. 377 (2): 109–12. doi: 10.1016/0014-5793(95)01315-6 . PMID 8543030. S2CID 27119138.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000152932 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021700 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12296628-5] Cheng H, Ma Y, Ni X, Jiang M, Luo Y, Ying K, Xie Y, Ma Y (Aug 2002). "Cloning, mapping, and characterization of the human Rab3C gene". Biochemical Genetics. 40 (7–8): 263–72. doi:10.1023/A:1019834901190. PMID 12296628. S2CID 10653465.

[entrez-6] "Entrez Gene: RAB3C RAB3C, member RAS oncogene family".

[pmid18625232-7] van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters. 582 (19): 2838–42. doi: 10.1016/j.febslet.2008.07.012 . PMID 18625232. S2CID 30206840.

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RAB3C

Contents

Interactions

Related Research Articles

References

Further reading