DSN1

DSN1
Identifiers
Aliases	DSN1 , C20orf172, KNL3, MIS13, dJ469A13.2, hKNL-3, DSN1 homolog, MIS12 kinetochore complex component, DSN1 component of MIS12 kinetochore complex
External IDs	OMIM: 609175; MGI: 1914184; HomoloGene: 49806; GeneCards: DSN1; OMA:DSN1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.23 Start 36,751,791 bp [1] End 36,773,818 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 156,837,185 bp [2] End 156,849,074 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone right testis secondary oocyte left testis ganglionic eminence testicle rectum right adrenal cortex mucosa of transverse colon Top expressed in zygote secondary oocyte spermatocyte primary oocyte spermatid genital tubercle yolk sac ventricular zone tail of embryo morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component MIS12/MIND type complex chromosome, centromeric region nucleus kinetochore chromosome extracellular region cytosol azurophil granule lumen nuclear MIS12/MIND complex spindle pole fibrillar center nucleolus nuclear body Biological process chromosome segregation cell division cell cycle neutrophil degranulation mitotic sister chromatid segregation attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79980 66934 Ensembl ENSG00000149636 ENSMUSG00000027635 UniProt Q9H410 Q9CYC5 RefSeq (mRNA) NM_001145315 NM_001145316 NM_001145317 NM_001145318 NM_024918 NM_025853 RefSeq (protein) NP_001138787 NP_001138788 NP_001138789 NP_001138790 NP_079194 NP_080129 Location (UCSC) Chr 20: 36.75 – 36.77 Mb Chr 2: 156.84 – 156.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene. ^{[5] [6]}

Function

DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore-associated multiprotein complex which is required for correct chromosome alignment during the metaphase of cell mitosis. ^{[6] [7]}

Interactions

DSN1 has been shown to interact with NSL1 ^[8] and MIS12. ^{[6] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000149636 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027635 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)".
6. Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID   15502821. S2CID   39408000.
7. Yang Y, Wu F, Ward T, Yan F, Wu Q, Wang Z, McGlothen T, Peng W, You T, Sun M, Cui T, Hu R, Dou Z, Zhu J, Xie W, Rao Z, Ding X, Yao X (September 2008). "Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore". J. Biol. Chem. 283 (39): 26726–36. doi: 10.1074/jbc.M804207200 . PMC   2546542 . PMID   18640974.
8. Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11). England: 1135–41. doi:10.1038/ncb1187. ISSN   1465-7392. PMID   15502821. S2CID   39408000.
9. Cheeseman, Iain M; Niessen Sherry; Anderson Scott; Hyndman Francie; Yates John R; Oegema Karen; Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18). United States: 2255–68. doi:10.1101/gad.1234104. ISSN   0890-9369. PMC   517519 . PMID   15371340.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Kline SL, Cheeseman IM, Hori T, et al. (2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". J. Cell Biol. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC   2063780 . PMID   16585270.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Obuse C, Iwasaki O, Kiyomitsu T, et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID   15502821. S2CID   39408000.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Cheeseman IM, Niessen S, Anderson S, et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC   517519 . PMID   15371340.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.