DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene. [5] [6]
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene. [5] [6]
DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore-associated multiprotein complex which is required for correct chromosome alignment during the metaphase of cell mitosis. [6] [7]
DSN1 has been shown to interact with NSL1 [8] and MIS12. [6] [9]
Centromere protein F is a protein that in humans is encoded by the CENPF gene. It is involved in chromosome segregation during cell division. It also has a role in the orientation of microtubules to form cellular cilia.
Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.
Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.
Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.
Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.
Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.
Centromere protein U is a protein that in humans is encoded by the CENPU gene.
Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.
COP9 signalosome complex subunit 7a is a protein that in humans is encoded by the COPS7A gene.
ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene.
Centromere protein H is a protein that in humans is encoded by the CENPH gene.
Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene. It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called HP1α. Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins.
KNL1 is a protein that is encoded by the KNL1 gene in humans.
Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.
Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.
Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.
Centromere protein T is a protein that in humans is encoded by the CENPT gene.
Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.
Centromere protein N is a protein that in humans is encoded by the CENPN gene.
Centromere protein L is a protein that in humans is encoded by the CENPL gene.
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