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Pornanong Aramwit | |
---|---|
Born | 1970 (age 53–54) |
Occupation(s) | Pharmaceutical scientist, pharmacist, academic, and author |
Awards | Outstanding Professional Women Award, Federation of Business and Professional Women of Thailand (2019) National Outstanding Researcher Award, National Research Council of Thailand (NRCT) (2024) |
Academic background | |
Education | BSc in Pharmacy PharmD PhD in Pharmaceutical Sciences |
Alma mater | Chulalongkorn University University of Illinois-Chicago University of Wisconsin–Madison |
Thesis | The Effect of Serum Albumin and Pluronics on the Aggregation State and Toxicity of Polyene Macrolides (2000) |
Academic work | |
Institutions | Chulalongkorn University (CU) |
Pornanong Aramwit is a pharmaceutical scientist,pharmacist,academic,and author. She serves as the Dean of the Faculty of Pharmaceutical Sciences at Chulalongkorn University (CU) [1] and is also a member of the university's Council, [2] Administrative Board of the National Innovation Agency, [3] and the Royal Society of Thailand. [4]
Aramwit's research has encompassed protein research,including silk proteins,biomaterials,tissue engineering,and herbal substances. She has conducted clinical studies in nephrology and has been researching dermatology,focusing on materials for wound healing applications. She is an inventor in medical devices and the food industry,and has received over 100 awards including the Merits of Leadership Award Grand Officer Level:Number of the cross 1156 from the UK, [5] the Merits of Innovation Grand Officer Level:Number of the cross 30705 from France,and the Merits of Innovation Ribbon of Honor:Number of the cross 16834 from Belgium,as well as from the European Union and Spain. Additionally,she was awarded the 2018 Ambassador Award for Innovator with Outstanding Achievements,the 2019 Outstanding Professional Women Award by the Federation of Business and Professional Women of Thailand, [6] and the 2024 National Outstanding Researcher Award by the National Research Council of Thailand (NRCT). [7]
Aramwit has authored more than 220 peer-reviewed articles,authored/co-authored several books and book chapters,has 20 patents, [8] [9] [10] and has received awards for her innovations. [11] [12] [13]
Representing Thailand at international conferences,Aramwit has served as a jury member on their boards,which include Brussels Innova,Innova Barcelona,Inova-Budi Uzor (Croatia), [14] the Iranian Top Inventor Association,and INTARG. [15]
Aramwit earned a B.Sc. in Pharmacy from CU in 1992,Doctor of Pharmacy from the University of Illinois-Chicago,USA in 1995 and a Ph.D. from the University of Wisconsin–Madison,USA in 2001. [16] [17]
Aramwit's career started as a Formulator/Research Investigator at Pfizer Pharmaceutical Worldwide in the USA. She then served as the deputy director for International Affairs and Immigrant Workers at the Internal Security Operations Command in Thailand from April 2014 to 2017. Since then,she has been serving as the Acting Vice President on the President and Administrative Board, [2] while concurrently holding the position of Director of Research Projects at Center of Excellence in Bioactive Resources for Innovative Clinical Applications (BRICA) [18] and Dean of the Faculty of Pharmaceutical Sciences at the Department of Pharmacy Practice (PharmCU) at CU. [1] Within these roles,she oversaw collaborations on nutritional supplements with Innobic (Asia) and TISTR, [19] led skincare product development with CU Innovation Hub and UMI Deeptech, [20] and contributed to StemAktiv's research,highlighting its potential in skincare and aging treatment with safe herbal extracts, [21] while also overseeing CU's Faculty of Pharmaceutical Sciences signing an MOU with Mahidol University [22] and another MOU with Degree Plus. [23] In addition,she has been appointed as an adjunct professor in the Faculty of Pharmacy at the Silpakorn University in Thailand and a visiting professor at the Institute of Natural Medicine of the University of Toyama in Japan. [24]
Aramwit authored Silk:Properties,Production and Uses in 2012,delving into the applications of silkworm products in medicine and textiles. In 2021,she co-wrote Sustainable Uses of Byproducts from Silk Processing with Narendra Reddy,focusing on the sustainable utilization of silk by-products across materials,energy,food,cosmetics,and environmental cleanup,with an emphasis on silk proteins in industries like cancer treatment and pharmaceuticals. Her research on silk sericin highlighted fibroin's applications in textiles and biomaterials,alongside discoveries in cosmetics and pharmaceuticals, [25] while examining the effects of different extraction methods on sericin's properties,including cell behavior and collagen production, [26] finding that urea-extracted sericin most effectively reduced melanin content and cellular tyrosinase activity,suggesting its potential use in treating hyperpigmentation. [27] Additionally,she noted sericin's induction of IL-1βand TNF-αin vitro without other inflammatory effects. [28]
Aramwit found that sericin reduced inflammation,sped healing,and boosted collagen in rat wounds, [29] with anti-inflammatory effects comparable to betamethasone and calcitriol in her psoriasis study. [30] She later developed eco-friendly agarose and sericin scaffolds for enhanced drug release and wound healing. [31]
Aramwit coedited Nanotechnology in Drug Delivery with Glen S. Kwon and Melgardt M. de Villiers,exploring nanotechnology-based drug delivery systems and their application for the delivery of small molecules,proteins,peptides,oligonucleotides,and genes. Her research highlighted that alginate/chitosan beads enhance the stability and bioavailability of mulberry-extracted anthocyanin,with 0.05% chitosan solution proving most effective for encapsulation and gastric resistance, [32] while Eugenol-embedded calcium citrate nanoparticles (Eu-CaCit NPs) show potential as a biocompatible topical delivery system,improving dermal penetration and reducing skin irritation. [33]
Aramwit's work has encompassed clinical and therapeutic evaluations across various health conditions. She found that mulberry leaves containing 12 mg of 1-deoxynojirimycin reduced fasting plasma glucose and glycated hemoglobin in obese individuals with borderline diabetes,with minimal side effects, [34] and observed that their leaf powder also lowered triglyceride,LDL,and CRP levels in patients with mild dyslipidemia. [35] In her collaborative studies,she discovered periostin as a biomarker for kidney disease severity in IgA nephropathy, [36] demonstrated oxymetholone's muscle-enhancing effects in hemodialysis patients with liver injury risks, [37] and detected ultrafiltration failure and fibrosis in long-term peritoneal dialysis patients through CA125 levels. [38] Among other research works,she developed P80,a longan extract spray reducing viral adhesion,including COVID-19,as a prevention alternative, [39] and explored crocetin's anti-cancer properties. [40]
Biopolymers are natural polymers produced by the cells of living organisms. Like other polymers,biopolymers consist of monomeric units that are covalently bonded in chains to form larger molecules. There are three main classes of biopolymers,classified according to the monomers used and the structure of the biopolymer formed:polynucleotides,polypeptides,and polysaccharides. The Polynucleotides,RNA and DNA,are long polymers of nucleotides. Polypeptides include proteins and shorter polymers of amino acids;some major examples include collagen,actin,and fibrin. Polysaccharides are linear or branched chains of sugar carbohydrates;examples include starch,cellulose,and alginate. Other examples of biopolymers include natural rubbers,suberin and lignin,cutin and cutan,melanin,and polyhydroxyalkanoates (PHAs).
Silk is a natural protein fiber,some forms of which can be woven into textiles. The protein fiber of silk is composed mainly of fibroin and is produced by certain insect larvae to form cocoons. The best-known silk is obtained from the cocoons of the larvae of the mulberry silkworm Bombyx mori reared in captivity (sericulture). The shimmering appearance of silk is due to the triangular prism-like structure of the silk fibre,which allows silk cloth to refract incoming light at different angles,thus producing different colors.
Chulalongkorn University,nicknamed Chula,is a public autonomous research university in Bangkok,Thailand. The university was originally founded during King Chulalongkorn's reign as a school for training royal pages and civil servants in 1899 at the Grand Palace of Thailand. It was later established as a national university in 1917,making it the oldest institute of higher education in Thailand.
A Doctor of Pharmacy is a professional doctorate in pharmacy. In some countries,it is a proficient graduate degree to practice the profession of pharmacy or to become a clinical pharmacist. In many countries,people with their Doctor of Pharmacy are allowed to practice independently and can prescribe drugs directly to patients. A PharmD program has significant experiential and/or clinical education components in introductory and advanced levels for the safe and effective use of drugs. Experiential education prepares graduates to be practice-ready,as they already have spent a significant amount of time training in areas of direct patient care and research.
Mahidol University is an autonomous public research university in Thailand. The university was founded as part of Siriraj Hospital in 1888. It was first called the University of Medical Science in 1943,and has been recognized as Thailand's fourth public university. The university was renamed in 1969 by King Bhumibol Adulyadej for his father,Prince Mahidol of Songkhla,known as the "Father of Modern Medicine and Public Health in Thailand".
Natural fibers or natural fibres are fibers that are produced by geological processes,or from the bodies of plants or animals. They can be used as a component of composite materials,where the orientation of fibers impacts the properties. Natural fibers can also be matted into sheets to make paper or felt.
Fibroin is an insoluble protein present in silk produced by numerous insects,such as the larvae of Bombyx mori,and other moth genera such as Antheraea,Cricula,Samia and Gonometa. Silk in its raw state consists of two main proteins,sericin and fibroin,with a glue-like layer of sericin coating two singular filaments of fibroin called brins. Silk fibroin is considered a β-keratin related to proteins that form hair,skin,nails and connective tissues.
Biotextiles are specialized materials engineered from natural or synthetic fibers. These textiles are designed to interact with biological systems,offering properties such as biocompatibility,porosity,and mechanical strength or are designed to be environmentally friendly for typical household applications. There are several uses for biotextiles since they are a broad category. The most common uses are for medical or household use. However,this term may also refer to textiles constructed from biological waste product. These biotextiles are not typically used for industrial purposes.
A nerve guidance conduit is an artificial means of guiding axonal regrowth to facilitate nerve regeneration and is one of several clinical treatments for nerve injuries. When direct suturing of the two stumps of a severed nerve cannot be accomplished without tension,the standard clinical treatment for peripheral nerve injuries is autologous nerve grafting. Due to the limited availability of donor tissue and functional recovery in autologous nerve grafting,neural tissue engineering research has focused on the development of bioartificial nerve guidance conduits as an alternative treatment,especially for large defects. Similar techniques are also being explored for nerve repair in the spinal cord but nerve regeneration in the central nervous system poses a greater challenge because its axons do not regenerate appreciably in their native environment.
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Andreas Bernkop-Schnürch is an Austrian scientist and entrepreneur,who is Head of the Department of Pharmaceutical Technology in the Institute of Pharmacy at the University of Innsbruck.
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Gelita AG is a manufacturer of gelatin and collagen peptides for the food,health and nutrition,pharmaceutical industries and for several technical applications. It is headquartered in Eberbach,Germany.
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