Prefoldin subunit 6

PFDN6
Identifiers
Aliases	PFDN6 , H2-KE2, HKE2, KE-2, PFD6, prefoldin subunit 6
External IDs	OMIM: 605660; MGI: 95908; HomoloGene: 40720; GeneCards: PFDN6; OMA:PFDN6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.32 Start 33,289,302 bp [1] End 33,298,401 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 B1|17 17.98 cM Start 34,157,795 bp [2] End 34,159,317 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis hypothalamus islet of Langerhans Brodmann area 9 hippocampus proper amygdala mucosa of transverse colon substantia nigra caudate nucleus Top expressed in primitive streak yolk sac epiblast medial ganglionic eminence neural layer of retina fossa morula morula embryo condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding chaperone binding Cellular component cytoplasm prefoldin complex Biological process chaperone-mediated protein complex assembly protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10471 14976 Ensembl ENSG00000237335 ENSG00000204220 ENSG00000235692 ENSG00000206283 ENSG00000224782 n/a ENSMUSG00000024309 UniProt O15212 Q5STK2 Q03958 RefSeq (mRNA) NM_014260 NM_001185181 NM_001265595 NM_001265596 NM_001185182 NM_010385 RefSeq (protein) NP_001172110 NP_001252524 NP_001252525 NP_055075 NP_001172110.1 NP_001252524.1 NP_001252525.1 NP_055075.1 NP_001172111 NP_034515 Location (UCSC) Chr 6: 33.29 – 33.3 Mb Chr 17: 34.16 – 34.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prefoldin subunit 6 is a protein that in humans is encoded by the PFDN6 gene. ^{[5] [6] [7]}

References

1. ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 GRCh38: Ensembl release 89: ENSG00000237335, ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024309 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Herberg JA, Beck S, Trowsdale J (May 1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J Mol Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID   9545376.
6. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi: 10.1016/S0092-8674(00)81446-4 . PMID   9630229. S2CID   16011829.
7. "Entrez Gene: PFDN6 prefoldin subunit 6".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Herberg JA, Sgouros J, Jones T, et al. (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC". Eur. J. Immunol. 28 (2): 459–67. doi: 10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z . PMID   9521053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi: 10.1074/jbc.M306053200 . PMID   14634002.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ostrov DA, Barnes CL, Smith LE, et al. (2007). "Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex". Tissue Antigens. 69 (2): 181–8. doi:10.1111/j.1399-0039.2006.00730.x. PMID   17257322.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.