Princess Imoukhuede

Last updated
Princess Imoukhuede
Born
Princess Izevbua Imoukhuede

1980 (age 43–44)
Alma mater Massachusetts Institute of Technology
California Institute of Technology
Awards National Science Foundation CAREER Award (2017)
Scientific career
Fields Systems Biology
Vascular Biology
Cellular and Molecular Bioengineering
Regenerative Medicine [1]
Institutions Washington University in St. Louis
Johns Hopkins University
University of Illinois at Urbana–Champaign
Thesis Visualizing the membrane confinement, trafficking and structure of the GABA transporter, GAT1  (2008)
Doctoral advisor Henry A. Lester [2]
Website imoukhuedelab.wustl.edu OOjs UI icon edit-ltr-progressive.svg

Princess Imoukhuede (born 1980) is an American chemical engineer who is a Professor in Bioengineering at the University of Washington. [3] Before 2022, she was an associate professor at the Washington University in St. Louis. She was awarded the 2018 Illinois Mathematics and Science Academy Distinguished Leadership Award and the 2018 Nano Research Young Innovators Award in Nanobiotechnology. Her first name is 'Princess' and she holds no royal title or position in any capacity.

Contents

Early life and education

Imoukhuede grew up in Matteson, Illinois. [4] She was involved with track and field as a child, and competed in shot put from the age of eight. By the time she was in eighth grade she had become interested in science, and her parents gave her a chemistry set to play with at home. [5] Imoukhuede attended the Illinois Mathematics and Science Academy. [5] Imoukhuede was an undergraduate student in biomedical engineering at Massachusetts Institute of Technology (MIT), where she performed undergraduate research under the supervision of Robert S. Langer on the incorporation of adenoviruses in a liposome-based gene therapy system. In her freshman year she was honoured at the Eastern College Athletic Conference, and was the first woman from MIT to qualify for the National Collegiate Athletic Association.[ citation needed ] Whilst at MIT, Imoukhuede took part in athletics, serving as captain of the varsity track and field team. Imoukhuede was described by Roger Crosley, then MIT Director of Sport, as "the best weight thrower we ever had in track and field".[ citation needed ] After earning her bachelor's degree, Imoukhuede moved to the California Institute of Technology, where she worked with Henry A. Lester on the structure of the GABA transporter and Förster resonance energy transfer. [2] She was the first African American woman to receive a PhD in bioengineering from Caltech. [3]

Research and career

Imoukhuede was a postdoctoral scholar at Johns Hopkins University, where she specialised in biomedical engineering in the laboratory of Aleksander Popel. [5] She started working on the vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in ischemia and cancer. After completing her postdoctoral research, Imoukhuede joined the University of Illinois at Urbana–Champaign. [6] Currently, Imoukhuede is a professor of bioengineering at the University of Washington as the Hunter and Dorthy Simpson Endowed Chair. [7]

Imoukhuede studies the mechanisms that regulate angiogenic signalling, including tyrosine kinase receptors, VEGF receptors and platelet-derived growth factor receptors. In 2019 Imoukhuede and Sarah K. England partnered to improve the efficacy and safety of oxytocin during labour. [8] Imoukhuede is developing a computational model that could be used to predict the function of oxytocin receptor function. [8] Her current focus is to unravel the complexities governing blood-vessel formation which gives the potential for treatment for several diseases such as breast cancer and some cardiovascular diseases. [9]

Awards and honours

Selected publications

Her publications [1] include:

Related Research Articles

<span class="mw-page-title-main">Angiogenesis</span> Blood vessel formation, when new vessels emerge from existing vessels

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis. Angiogenesis continues the growth of the vasculature mainly by processes of sprouting and splitting, but processes such as coalescent angiogenesis, vessel elongation and vessel cooption also play a role. Vasculogenesis is the embryonic formation of endothelial cells from mesoderm cell precursors, and from neovascularization, although discussions are not always precise. The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease.

<span class="mw-page-title-main">Platelet-derived growth factor</span> Signaling glycoprotein regulating cell proliferation

Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant role in blood vessel formation, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells. Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF-BB), or one of each (PDGF-AB).

Vascular endothelial growth factor, originally known as vascular permeability factor (VPF), is a signal protein produced by many cells that stimulates the formation of blood vessels. To be specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis and angiogenesis.

<span class="mw-page-title-main">Angiopoietin</span> Protein family

Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from preexisting blood vessels. Angiogenesis proceeds through sprouting, endothelial cell migration, proliferation, and vessel destabilization and stabilization. They are responsible for assembling and disassembling the endothelial lining of blood vessels. Angiopoietin cytokines are involved with controlling microvascular permeability, vasodilation, and vasoconstriction by signaling smooth muscle cells surrounding vessels. There are now four identified angiopoietins: ANGPT1, ANGPT2, ANGPTL3, ANGPT4.

<span class="mw-page-title-main">VEGFR1</span> Protein-coding gene in the species Homo sapiens

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.

<span class="mw-page-title-main">Vascular endothelial growth factor C</span> Growth factor protein found in humans

Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. It is encoded in humans by the VEGFC gene, which is located on chromosome 4q34.

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Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins.

<span class="mw-page-title-main">Vascular endothelial growth factor B</span> Protein-coding gene in the species Homo sapiens

Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene. VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member.

<span class="mw-page-title-main">GABRD</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 Princess Imoukhuede publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  2. 1 2 Imoukhuede, Princess Izevbua (2008). Visualizing the membrane confinement, trafficking and structure of the GABA transporter, GAT1 (PhD thesis). Pasadena, California: California Institute of Technology. OCLC   437168185.
  3. 1 2 "Meet Princess Imoukhuede | UW Bioengineering". 2022-02-18. Retrieved 2023-10-17.
  4. ↑ "Princess Imoukhuede". MIT Spectrum. Retrieved 2020-10-21.
  5. 1 2 3 4 5 "410: Dr. Princess Imoukhuede: Making Sense of the Signaling Networks that Stimulate Blood Vessel Formation". People Behind the Science Podcast. 2017-08-14. Retrieved 2020-10-21.
  6. ↑ "Imoukhuede Systems Biology Laboratory" . Retrieved 2020-10-22.
  7. 1 2 Berger, Norbert (2022-02-18). "Meet Princess Imoukhuede | UW Bioengineering" . Retrieved 2024-03-20.
  8. 1 2 "Imoukhuede teams with England on $2.4M NIH grant". engineering.wustl.edu. 11 September 2019. Retrieved 2020-10-21.
  9. ↑ PBtS (2017-08-14). "410: Dr. Princess Imoukhuede: Making Sense of the Signaling Networks that Stimulate Blood Vessel Formation". People Behind the Science Podcast. Retrieved 2024-03-20.
  10. ↑ "Princess Imoukhuede – Miniature Brain Machinery" . Retrieved 2024-03-20.
  11. ↑ "NSF Award Search: Award#1653925 - CAREER: qBio+cBio=sBio; Identifying the role of cross-family signaling in angiogenesis". nsf.gov. Retrieved 2020-10-21.
  12. ↑ Communications, Grainger Engineering Office of Marketing and. "Princess Imoukhuede earns IMSA Distinguished Leadership Award". grainger.illinois.edu. Retrieved 2024-03-20.
  13. 1 2 "Princess Imoukhuede". www.aiche.org. 2020-07-21. Retrieved 2024-03-20.
  14. ↑ Napier, Douglas H. (1992). "Workbook of test cases for vapor cloud source dispersion models, By Steven R. Hanna and David Strimaitis for the Centre for Chemical Process Safety of the American Institute of Chemical Engineers 1989, 122 + xv pages". The Canadian Journal of Chemical Engineering. 70 (4). New York: American Institute of chemical Engineers: 831. doi:10.1002/cjce.5450700433. ISBN   0-8169-0455-3. ISSN   0008-4034.
  15. ↑ "Imoukhuede receives 2021 BMES Mid-Career Award". engineering.wustl.edu. 2021-09-20. Retrieved 2024-03-20.
  16. ↑ Drenan, Ryan M.; Nashmi, Raad; Imoukhuede, Princess; Just, Herwig; McKinney, Sheri; Lester, Henry A. (2008). "Subcellular Trafficking, Pentameric Assembly, and Subunit Stoichiometry of Neuronal Nicotinic Acetylcholine Receptors Containing Fluorescently Labeled α6 and β3 Subunits". Molecular Pharmacology. 73 (1): 27–41. doi:10.1124/mol.107.039180. ISSN   0026-895X. PMID   17932221. S2CID   14327818.
  17. ↑ Imoukhuede, P.I.; Popel, Aleksander S. (2011). "Quantification and cell-to-cell variation of vascular endothelial growth factor receptors". Experimental Cell Research. 317 (7): 955–965. doi:10.1016/j.yexcr.2010.12.014. ISSN   0014-4827. PMC   3073416 . PMID   21185287.
  18. ↑ Finley, Stacey D; Engel-Stefanini, Marianne O; Imoukhuede, PI; Popel, Aleksander S (2011). "Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies". BMC Systems Biology. 5 (1): 193. doi: 10.1186/1752-0509-5-193 . ISSN   1752-0509. PMC   3229549 . PMID   22104283.
  19. ↑ Rubin, Joshua B; Lagas, Joseph S; Broestl, Lauren; Sponagel, Jasmin; Rockwell, Nathan; Rhee, Gina; Rosen, Sarah F; Chen, Si; Klein, Robyn S; Imoukhuede, Princess; Luo, Jingqin (2020). "Sex differences in cancer mechanisms". Biology of Sex Differences. 11 (1): 17. doi: 10.1186/s13293-020-00291-x . ISSN   2042-6410. PMC   7161126 . PMID   32295632.
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