QSOX1

QSOX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LLI, 3LLK, 3Q6O, 4IJ3
Identifiers
Aliases	QSOX1 , Q6, QSCN6, quiescin sulfhydryl oxidase 1
External IDs	OMIM: 603120 MGI: 1330818 HomoloGene: 37690 GeneCards: QSOX1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q25.2 Start 180,154,834 bp [1] End 180,204,030 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 G3 Start 155,651,775 bp [2] End 155,688,635 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gallbladder upper lobe of left lung right lung body of stomach right coronary artery gastric mucosa left coronary artery mucosa of urinary bladder thoracic aorta Top expressed in seminal vesicula crypt of lieberkuhn of small intestine lip gallbladder esophagus superior surface of tongue spermatocyte ascending aorta liver aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity thiol oxidase activity protein disulfide isomerase activity flavin-linked sulfhydryl oxidase activity Cellular component integral component of membrane integral component of Golgi membrane Golgi membrane Golgi apparatus extracellular exosome intracellular membrane-bounded organelle membrane intercellular bridge extracellular region platelet alpha granule lumen extracellular space specific granule lumen tertiary granule lumen endoplasmic reticulum lumen Biological process negative regulation of macroautophagy cell redox homeostasis platelet degranulation neutrophil degranulation post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5768 104009 Ensembl ENSG00000116260 ENSMUSG00000033684 UniProt O00391 Q8BND5 RefSeq (mRNA) NM_002826 NM_001004128 NM_001024945 NM_023268 RefSeq (protein) NP_001004128 NP_002817 NP_001020116 NP_075757 Location (UCSC) Chr 1: 180.15 – 180.2 Mb Chr 1: 155.65 – 155.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sulfhydryl oxidase 1 is an enzyme that in humans is encoded by the QSOX1 gene. ^{[5] [6] [7]}

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116260 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033684 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Coppock DL, Cina-Poppe D, Gilleran S (Feb 1999). "The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1". Genomics. 54 (3): 460–8. doi: 10.1006/geno.1998.5605 . PMID   9878249.
6. Coppock DL, Kopman C, Scandalis S, Gilleran S (Oct 1993). "Preferential gene expression in quiescent human lung fibroblasts". Cell Growth Differ. 4 (6): 483–93. PMID   8396966.
7. "Entrez Gene: QSCN6 quiescin Q6".

Further reading

• Thorpe C, Hoober KL, Raje S, et al. (2002). "Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes". Arch. Biochem. Biophys. 405 (1): 1–12. doi:10.1016/S0003-9861(02)00337-5. PMID   12176051.
• Hoober KL, Glynn NM, Burnside J, et al. (1999). "Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases". J. Biol. Chem. 274 (45): 31759–62. doi: 10.1074/jbc.274.45.31759 . PMID   10542195.
• Coppock D, Kopman C, Gudas J, Cina-Poppe DA (2000). "Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29". Biochem. Biophys. Res. Commun. 269 (2): 604–10. doi:10.1006/bbrc.2000.2324. PMID   10708601.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Radom J, Colin D, Thiebault F, et al. (2006). "Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain". Biochim. Biophys. Acta. 1759 (5): 225–33. doi:10.1016/j.bbaexp.2006.04.008. PMID   16806532.
• Chakravarthi S, Jessop CE, Willer M, et al. (2007). "Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1". Biochem. J. 404 (3): 403–11. doi:10.1042/BJ20061510. PMC   1896280 . PMID   17331072.
• Jaje J, Wolcott HN, Fadugba O, et al. (2007). "A flavin-dependent sulfhydryl oxidase in bovine milk". Biochemistry. 46 (45): 13031–40. doi:10.1021/bi7016975. PMC   2518652 . PMID   17944490.