Questiomycin A

Last updated
Questiomycin A
Questiomycin A Structure.svg
Names
Preferred IUPAC name
2-Amino-3H-phenoxazin-3-one
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
KEGG
PubChem CID
  • InChI=1S/C12H8N2O2/c13-7-5-9-12(6-10(7)15)16-11-4-2-1-3-8(11)14-9/h1-6H,13H2
    Key: RDJXPXHQENRCNG-UHFFFAOYSA-N
  • InChI=1/C12H8N2O2/c13-7-5-9-12(6-10(7)15)16-11-4-2-1-3-8(11)14-9/h1-6H,13H2
    Key: RDJXPXHQENRCNG-UHFFFAOYAN
  • C1=CC=C2C(=C1)N=C3C=C(C(=O)C=C3O2)N
Properties
C12H8N2O2
Molar mass 212.208 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Questiomycin A is an antibiotic made by the fungus Penicillium expansum . [1]

See also

Related Research Articles

<i>Penicillium</i> Genus of fungi

Penicillium is a genus of ascomycetous fungi that is part of the mycobiome of many species and is of major importance in the natural environment, in food spoilage, and in food and drug production.

<i>Talaromyces marneffei</i> Species of fungus

Talaromyces marneffei, formerly called Penicillium marneffei, was identified in 1956. The organism is endemic to southeast Asia where it is an important cause of opportunistic infections in those with HIV/AIDS-related immunodeficiency. Incidence of T. marneffei infections has increased due to a rise in HIV infection rates in the region.

A mycotoxin is a toxic secondary metabolite produced by organisms of the fungus kingdom and is capable of causing disease and death in both humans and other animals. The term 'mycotoxin' is usually reserved for the toxic chemical products produced by fungi that readily colonize crops.

Blue cheese Type of cheese

Blue cheese or bleu cheese is cheese made with cultures of the mold Penicillium, giving it spots or veins of the mold throughout the cheese, which can vary in color through various shades of blue and green. This carries a distinct smell, either from that or various specially cultivated bacteria. Some blue cheeses are injected with spores before the curds form, and others have spores mixed in with the curds after they form. Blue cheeses are typically aged in a temperature-controlled environment such as a cave. Blue cheese can be eaten by itself or can be spread, crumbled or melted into or over a range of other foods. Blue cheese is known for its pungent creamy texture.

Trichocomaceae Family of fungi

The Trichocomaceae are a family of fungi in the order Eurotiales. Taxa are saprobes with aggressive colonization strategies, adaptable to extreme environmental conditions. Family members are cosmopolitan in distribution, ubiquitous in soil, and common associates of decaying plant and food material. The family contains some of the most familiar fungi, such as Penicillium and Aspergillus. It has been proposed that the family should be split into the three families Aspergillaceae, Thermoascaceae and Trichocomaceae.

<i>Penicillium roqueforti</i> Species of fungus

Penicillium roqueforti is a common saprotrophic fungus in the genus Penicillium. Widespread in nature, it can be isolated from soil, decaying organic matter, and plants.

Mevastatin

Mevastatin is a hypolipidemic agent that belongs to the statins class.

Hyphomycetes are a form classification of Fungi, part of what has often been referred to as Fungi imperfecti, Deuteromycota, or anamorphic fungi. Hyphomycetes lack closed fruit bodies, and are often referred to as moulds. Most hyphomycetes are now assigned to the Ascomycota, on the basis of genetic connections made by life-cycle studies or by phylogenetic analysis of DNA sequences; many remain unassigned phylogenetically. Identification of hyphomycetes is primarily based on microscopic morphology including: conidial morphology, especially septation, shape, size, colour and cell wall texture, the arrangement of conidia as they are borne on the conidiogenous cells, the type of conidiogenous cell, and other additional features such as the presence of sporodochia or synnemata.

<i>Penicillium expansum</i> Species of fungus

Penicillium expansum is a psychrophilic blue mold that is common throughout the world in soil. It causes Blue Mold of apples, one of the most prevalent and economically damaging post-harvest diseases of apples.

Xantocillin Chemical compound

Xantocillin (INN), also known as xanthocillin X or ophthocillin, was the first reported natural product found to contain the isocyanide functional group. It was first isolated from Penicillium notatum by Rothe in 1950 and subsequently from several other sources.

<i>Catasetum expansum</i> Species of orchid

Catasetum expansum, the expansive catasetum, is a species of orchid found in Ecuador.

<i>Penicillium chrysogenum</i> Species of fungus

Penicillium chrysogenum is a species of fungus in the genus Penicillium. It is common in temperate and subtropical regions and can be found on salted food products, but it is mostly found in indoor environments, especially in damp or water-damaged buildings. It has been recognised as a species complex that includes P. notatum, P. meleagrinum, and P. cyaneofulvum, but molecular phylogeny established that it is a distinct species and that P. notatum is P. rubens. It has rarely been reported as a cause of human disease. It is the source of several β-lactam antibiotics, most significantly penicillin. Other secondary metabolites of P. chrysogenum include roquefortine C, meleagrin, chrysogine, 6-MSA YWA1/melanin, andrastatin A, fungisporin, secalonic acids, sorbicillin, and PR-toxin.

Penicillopepsin is an enzyme. This enzyme catalyses the following chemical reaction

Medicinal fungi are fungi which contain metabolites or can be induced to produce metabolites through biotechnology to develop prescription drugs. Compounds successfully developed into drugs or are under research include antibiotics, anti-cancer drugs, cholesterol and ergosterol synthesis inhibitors, psychotropic drugs, immunosuppressants and fungicides.

Penicillium citrinum is an anamorph, mesophilic fungus species of the genus of Penicillium which produces tanzawaic acid A-D, ACC, Mevastatin, Quinocitrinine A, Quinocitrinine B, and nephrotoxic citrinin. Penicillium citrinum is often found on moldy citrus fruits and occasionally it occurs in tropical spices and cereals. This Penicillium species also causes mortality for the mosquito Culex quinquefasciatus. Because of its mesophilic character, Penicillium citrinum occurs worldwide. The first statin (Mevastatin) was 1970 isolated from this species.

<i>Mesophyllum expansum</i> Species of alga

Mesophyllum expansum is a species of red alga belonging to the family Hapalidiaceae.

Metschnikowia pulcherrima is a ubiquitous species of yeast, with numerous strains, belonging to the family Metschnikowiaceae, and found on grapes, cherries, flowers, spoiled fruit and consequently carried by fruit flies. It is a non-Saccharomyces yeast and plays an important role in the vinification of wine when it is present on grapes or winery equipment, and has historically seen use in South Africa’s wine industry. It is also being studied at the University of Bath as a possible alternative to the use of Palm oil, and early results show promise. M. pulcherrima is ovoid to ellipsoidal in shape and reproduces by budding. Its cells are globose and thick-walled, holding a single, large oil droplet of high refractive index. As the result of incomplete budding where cells remain attached after division, pseudohyphae may form under anaerobic conditions.

Streptomyces tendae is a bacterium species from the genus of Streptomyces which has been isolated from soil in France. Streptomyces tendae produces carbomycin, streptofactin, geosmin, cervimycin A-D and nikkomycins. Also said to be the source of Tendamistat, an alpha amylase inhibitor.

<i>Penicillium spinulosum</i> Species of fungus

Penicillium spinulosum is a non-branched, fast-growing fungus with a swelling at the terminal of the stipe (vesiculate) in the genus Penicillium. P. spinulosum is able to grow and reproduce in environment with low temperature and low water availability, and is known to be acidotolerant. P. spinulosum is ubiquitously distributed, and can often be isolated from soil. Each individual strain of P. spinulosum differs from others in their colony morphology, including colony texture, amount of sporulation and roughness of conidia and conidiophores.

References

  1. Kozlovskiĭ, A. G.; Zhelifonova, V. P.; Antipova, T. V.; Adanin, V. M.; Novikova, N. D.; Deshevaia, E. A.; Schlegel, B.; Dahse, H. M.; Gollmick, F. A.; Grafe, U. (2004). "Penicillium expansum, a resident fungal strain of the orbital complex Mir, producing xanthocillin X and questiomycin A". Prikladnaia Biokhimiia I Mikrobiologiia. 40 (3): 344–9. PMID   15283339.