Quinethazone

Quinethazone
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Oral
ATC code	C03BA02 ( WHO );
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-; 6-sulfonamide;
CAS Number	73-49-4 ;
PubChem CID	6307 ;
IUPHAR/BPS	7289 ;
DrugBank	DB01325 ;
ChemSpider	6068 ;
UNII	455E0S048W ;
KEGG	D00461 ;
ChEMBL	ChEMBL1532 ;
CompTox Dashboard (EPA)	DTXSID9023548 ;
ECHA InfoCard	100.000.729
Chemical and physical data
Formula	C10H12ClN3O3S
Molar mass	289.73 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES O=S(=O)(c2c(Cl)cc1c(C(=O)NC(N1)CC)c2)N;
	InChI InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17) ; Key:AGMMTXLNIQSRCG-UHFFFAOYSA-N ;
	(verify)

Last updated January 01, 2026

Quinethazone (INN, brand name Hydromox) is a thiazide-like diuretic used to treat hypertension.^[1] Common side effects include dizziness, dry mouth, nausea, and low potassium levels.

References

↑ Sandler G (August 1964). "Quinethazone, a new oral diuretic". British Medical Journal. 2 (5404): 288–92. doi:10.1136/bmj.2.5404.288. PMC 1815620 . PMID 14160213.

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[pmid14160213-1] Sandler G (August 1964). "Quinethazone, a new oral diuretic". British Medical Journal. 2 (5404): 288–92. doi:10.1136/bmj.2.5404.288. PMC 1815620 . PMID 14160213.

[1]

Clinical data

AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Oral
ATC code	C03BA02 ( WHO )
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline- 6-sulfonamide
CAS Number	73-49-4 ^Y
PubChem CID	6307
IUPHAR/BPS	7289
DrugBank	DB01325 ^Y
ChemSpider	6068 ^Y
UNII	455E0S048W
KEGG	D00461 ^Y
ChEMBL	ChEMBL1532 ^Y
CompTox Dashboard (EPA)	DTXSID9023548
ECHA InfoCard	100.000.729
Chemical and physical data
Formula	C₁₀H₁₂ClN₃O₃S
Molar mass	289.73 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=S(=O)(c2c(Cl)cc1c(C(=O)NC(N1)CC)c2)N
InChI InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)^Y Key:AGMMTXLNIQSRCG-UHFFFAOYSA-N^Y
(verify)