RAB11FIP3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | RAB11FIP3 , CART1, Rab11-FIP3, RAB11 family interacting protein 3, FIP3-Rab11 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 608738 MGI: 2444431 HomoloGene: 49396 GeneCards: RAB11FIP3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Rab11 family-interacting protein 3 is a protein that in humans is encoded by the RAB11FIP3 gene. [5] [6] [7]
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001).[supplied by OMIM] [7]
Melanophilin is a carrier protein which in humans is encoded by the MLPH gene. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.
Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1 gene. Its gene product, as well as the gene itself, is commonly known as TIP47.
Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.
ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.
Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a protein that in humans is encoded by the RAB11FIP1 gene.
Rab11 family-interacting protein 2 is a protein that in humans is encoded by the RAB11FIP2 gene.
Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.
Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene.
Ras-related protein Rab-13 is a protein that in humans is encoded by the RAB13 gene.
Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.
ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.
Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene. It is thought to act as a promoter of tumor development.
RalBP1-associated Eps domain-containing protein 1 is a protein that in humans is encoded by the REPS1 gene.
Ras-related protein Rab-34 is a protein that in humans is encoded by the RAB34 gene.
GTPase activating protein and VPS9 domains 1, also known as GAPVD1, Gapex-5 and RME-6 is a protein which in humans is encoded by the GAPVD1 gene.
Ras-related protein Rab-37 is a protein that in humans is encoded by the RAB37 gene.
Ras-related protein Rab-8B is a protein that in humans is encoded by the RAB8B gene.
Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function.