RAB11FIP3

Last updated
RAB11FIP3
Protein RAB11FIP3 PDB 2d7c.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RAB11FIP3 , CART1, Rab11-FIP3, RAB11 family interacting protein 3, FIP3-Rab11
External IDs OMIM: 608738 MGI: 2444431 HomoloGene: 49396 GeneCards: RAB11FIP3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142272
NM_014700
NM_001370401

NM_001162868
NM_001162869
NM_153140

RefSeq (protein)

NP_001135744
NP_055515
NP_001357330

NP_001156340
NP_001156341
NP_694780

Location (UCSC) Chr 16: 0.43 – 0.52 Mb Chr 17: 26.21 – 26.29 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rab11 family-interacting protein 3 is a protein that in humans is encoded by the RAB11FIP3 gene. [5] [6] [7]

Contents

Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001).[supplied by OMIM] [7]

Interactions

RAB11FIP3 has been shown to interact with RAB11A. [8]

Related Research Articles

<span class="mw-page-title-main">Melanophilin</span>

Melanophilin is a carrier protein which in humans is encoded by the MLPH gene. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

<span class="mw-page-title-main">RAB11A</span>

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.

<span class="mw-page-title-main">Perilipin-3</span> Protein-coding gene in the species Homo sapiens

Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1 gene. Its gene product, as well as the gene itself, is commonly known as TIP47.

<span class="mw-page-title-main">GOPC</span>

Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.

<span class="mw-page-title-main">ARF4</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.

<span class="mw-page-title-main">RAB11FIP1</span> Protein-coding gene in the species Homo sapiens

Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a protein that in humans is encoded by the RAB11FIP1 gene.

<span class="mw-page-title-main">RAB11FIP2</span> Protein-coding gene in the species Homo sapiens

Rab11 family-interacting protein 2 is a protein that in humans is encoded by the RAB11FIP2 gene.

<span class="mw-page-title-main">CDC14A</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.

<span class="mw-page-title-main">RAB11FIP5</span>

Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene.

<span class="mw-page-title-main">RAB13</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-13 is a protein that in humans is encoded by the RAB13 gene.

<span class="mw-page-title-main">RAB22A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.

<span class="mw-page-title-main">BNIP2</span> Protein-coding gene in the species Homo sapiens

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.

<span class="mw-page-title-main">ARFRP1</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

<span class="mw-page-title-main">RAB25</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene. It is thought to act as a promoter of tumor development.

<span class="mw-page-title-main">REPS1</span>

RalBP1-associated Eps domain-containing protein 1 is a protein that in humans is encoded by the REPS1 gene.

<span class="mw-page-title-main">RAB34</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-34 is a protein that in humans is encoded by the RAB34 gene.

<span class="mw-page-title-main">GAPVD1</span> Protein-coding gene in the species Homo sapiens

GTPase activating protein and VPS9 domains 1, also known as GAPVD1, Gapex-5 and RME-6 is a protein which in humans is encoded by the GAPVD1 gene.

<span class="mw-page-title-main">RAB37</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-37 is a protein that in humans is encoded by the RAB37 gene.

<span class="mw-page-title-main">RAB8B</span>

Ras-related protein Rab-8B is a protein that in humans is encoded by the RAB8B gene.

<span class="mw-page-title-main">Giantin</span> Protein-coding gene in the species Homo sapiens

Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function.

References

  1. 1 2 3 ENSG00000275338 GRCh38: Ensembl release 89: ENSG00000090565, ENSG00000275338 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037098 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
  6. Prekeris R, Davies JM, Scheller RH (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J Biol Chem. 276 (42): 38966–70. doi: 10.1074/jbc.M106133200 . PMID   11481332.
  7. 1 2 "Entrez Gene: RAB11FIP3 RAB11 family interacting protein 3 (class II)".
  8. Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. United States. 276 (42): 39067–75. doi: 10.1074/jbc.M104831200 . ISSN   0021-9258. PMID   11495908.

Further reading