RAB8B

RAB8B
Identifiers
Aliases	RAB8B , member RAS oncogene family
External IDs	OMIM: 613532 MGI: 2442982 HomoloGene: 69220 GeneCards: RAB8B
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q22.2 Start 63,189,560 bp [1] End 63,267,776 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 C Start 66,750,946 bp [2] End 66,826,969 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Achilles tendon superficial temporal artery secondary oocyte cancellous bone germinal epithelium monocyte vena cava ganglionic eminence pericardium Top expressed in blood primitive streak medial ganglionic eminence calvaria carotid body ciliary body sexually immature organism skin of abdomen left lung lobe medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleotide binding signaling receptor binding GTP binding TPR domain binding GDP binding GTPase activity Cellular component mitochondrion peroxisomal membrane cell tip membrane phagocytic vesicle membrane perinuclear region of cytoplasm cytoplasmic vesicle phagocytic vesicle extracellular exosome nucleoplasm nuclear body intracellular membrane-bounded organelle recycling endosome membrane endosome plasma membrane synaptic vesicle secretory granule membrane trans-Golgi network transport vesicle presynapse Biological process vesicle docking involved in exocytosis protein secretion positive regulation of cell projection organization protein import into peroxisome membrane antigen processing and presentation adherens junction organization positive regulation of corticotropin secretion protein transport cilium assembly protein localization to plasma membrane regulation of exocytosis transport intracellular protein transport Rab protein signal transduction cellular response to insulin stimulus Golgi vesicle fusion to target membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51762 235442 Ensembl ENSG00000166128 ENSMUSG00000036943 UniProt Q92930 P61028 RefSeq (mRNA) NM_016530 NM_173413 RefSeq (protein) NP_057614 NP_775589 Location (UCSC) Chr 15: 63.19 – 63.27 Mb Chr 9: 66.75 – 66.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-8B is a protein that in humans is encoded by the RAB8B gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000166128 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036943 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen D, Guo J, Gahl WA (Mar 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. doi: 10.1016/S0167-4889(96)00169-3 . PMID   9030196.
6. Heidrych P, Zimmermann U, Bress A, Pusch CM, Ruth P, Pfister M, Knipper M, Blin N (Nov 2008). "Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form". Hum Mol Genet. 17 (23): 3814–21. doi:10.1093/hmg/ddn279. PMID   18772196.
7. "Entrez Gene: RAB8B RAB8B, member RAS oncogene family".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lau AS, Mruk DD (2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology. 144 (4): 1549–63. doi:10.1210/en.2002-220893. PMID   12639940.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hattula K, Furuhjelm J, Arffman A, Peränen J (2003). "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport". Mol. Biol. Cell. 13 (9): 3268–80. doi:10.1091/mbc.E02-03-0143. PMC   124888 . PMID   12221131.
• de Bruyn KM, de Rooij J, Wolthuis RM, et al. (2000). "RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral". J. Biol. Chem. 275 (38): 29761–6. doi: 10.1074/jbc.M001160200 . PMID   10889189.
• Armstrong J, Thompson N, Squire JH, et al. (1997). "Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3". J. Cell Sci. 109 (6): 1265–74. doi: 10.1242/jcs.109.6.1265 . PMID   8799816.