RADIL

RADIL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UM1, 3EC8
Identifiers
Aliases	RADIL , RASIP2, Rap associating with DIL domain
External IDs	OMIM: 611491 MGI: 2443088 HomoloGene: 77648 GeneCards: RADIL
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p22.1 Start 4,797,055 bp [1] End 4,883,716 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G2 Start 142,470,594 bp [2] End 142,536,853 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte cerebellar vermis pons tibial nerve sural nerve hypothalamus superior vestibular nucleus trigeminal ganglion right lung Top expressed in habenula seminiferous tubule spermatocyte cerebellar cortex superior cervical ganglion atrium dorsomedial hypothalamic nucleus superior frontal gyrus ventromedial nucleus sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component microtubule protein-containing complex Biological process multicellular organism development substrate adhesion-dependent cell spreading cell adhesion signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55698 231858 Ensembl ENSG00000157927 ENSMUSG00000029576 UniProt Q96JH8 Q69Z89 RefSeq (mRNA) NM_018059 NM_001289588 NM_178702 NM_001310752 RefSeq (protein) NP_060529 NP_001276517 NP_001297681 NP_848817 Location (UCSC) Chr 7: 4.8 – 4.88 Mb Chr 5: 142.47 – 142.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-associating and dilute domain-containing protein is a protein that in humans is encoded by the RADIL gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000157927 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029576 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang Z, Rehmann H, Price LS, Riedl J, Bos JL (Sep 2005). "AF6 negatively regulates Rap1-induced cell adhesion". J Biol Chem. 280 (39): 33200–5. doi: 10.1074/jbc.M505057200 . PMID   16051602.
6. Smolen GA, Schott BJ, Stewart RA, Diederichs S, Muir B, Provencher HL, Look AT, Sgroi DC, Peterson RT, Haber DA (Sep 2007). "A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors". Genes Dev. 21 (17): 2131–6. doi:10.1101/gad.1561507. PMC   1950852 . PMID   17704304.
7. "Entrez Gene: FLJ10324 hypothetical protein FLJ10324".

Further reading

• Ahmed SM, Daulat AM, Meunier A, Angers S (February 2010). "G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil". J. Biol. Chem. 285 (9): 6538–51. doi: 10.1074/jbc.M109.069948 . PMC   2825450 . PMID   20048162.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi: 10.1093/dnares/8.2.85 . PMID   11347906.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.