RASGRP3

RASGRP3
Identifiers
Aliases	RASGRP3 , GRP3, RAS guanyl releasing protein 3
External IDs	OMIM: 609531 MGI: 3028579 HomoloGene: 15019 GeneCards: RASGRP3
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p22.3 Start 33,436,324 bp [1] End 33,564,750 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 E2 Start 75,742,891 bp [2] End 75,836,049 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum inferior ganglion of vagus nerve subthalamic nucleus internal globus pallidus superior vestibular nucleus pons left ventricle lymph node mesencephalon substantia nigra Top expressed in iris retinal pigment epithelium triceps brachii muscle sternocleidomastoid muscle left lung lobe primitive streak vastus lateralis muscle temporal muscle right lung digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding guanyl-nucleotide exchange factor activity GTPase activator activity signal transducer activity metal ion binding kinase binding protein binding diacylglycerol binding Cellular component cytoplasm plasma membrane integral component of plasma membrane perinuclear region of cytoplasm guanyl-nucleotide exchange factor complex intracellular anatomical structure Biological process intracellular signal transduction regulation of GTPase activity small GTPase mediated signal transduction MAPK cascade positive regulation of GTPase activity Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25780 240168 Ensembl ENSG00000152689 ENSMUSG00000071042 UniProt Q8IV61 Q6NZH9 RefSeq (mRNA) NM_001139488 NM_015376 NM_170672 NM_001349975 NM_001349976 NM_001349977 NM_001349978 NM_001349979 NM_001349980 NM_001349981 NM_001166493 NM_207246 NM_001360103 RefSeq (protein) NP_001132960 NP_056191 NP_733772 NP_001336904 NP_001336905 NP_001336906 NP_001336907 NP_001336908 NP_001336909 NP_001336910 NP_001159965 NP_997129 NP_001347032 Location (UCSC) Chr 2: 33.44 – 33.56 Mb Chr 17: 75.74 – 75.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene. ^{[5] [6] [7]}

Function

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000). ^[7]

Interactions

RASGRP3 has been shown to interact with PRKCD. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000152689 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071042 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
6. Rebhun JF, Castro AF, Quilliam LA (Nov 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". The Journal of Biological Chemistry. 275 (45): 34901–8. doi: 10.1074/jbc.M005327200 . PMID   10934204.
7. "Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)".
8. Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM (Jul 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Molecular Pharmacology. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID   15213298. S2CID   5774849.

Further reading

• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Lorenzo PS, Kung JW, Bottorff DA, Garfield SH, Stone JC, Blumberg PM (Feb 2001). "Phorbol esters modulate the Ras exchange factor RasGRP3". Cancer Research. 61 (3): 943–9. PMID   11221888.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Teixeira C, Stang SL, Zheng Y, Beswick NS, Stone JC (Aug 2003). "Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3". Blood. 102 (4): 1414–20. doi: 10.1182/blood-2002-11-3621 . PMID   12730099.
• Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM (Jul 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Molecular Pharmacology. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID   15213298. S2CID   5774849.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Aiba Y, Oh-hora M, Kiyonaka S, Kimura Y, Hijikata A, Mori Y, Kurosaki T (Nov 2004). "Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation". Proceedings of the National Academy of Sciences of the United States of America. 101 (47): 16612–7. Bibcode:2004PNAS..10116612A. doi: 10.1073/pnas.0407468101 . PMC   528733 . PMID   15545601.
• Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL (Dec 2004). "A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters". Molecular and Cellular Biology. 24 (24): 10515–28. doi:10.1128/MCB.24.24.10515-10528.2004. PMC   533983 . PMID   15572660.
• Zheng Y, Liu H, Coughlin J, Zheng J, Li L, Stone JC (May 2005). "Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells". Blood. 105 (9): 3648–54. doi: 10.1182/blood-2004-10-3916 . PMID   15657177.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Okamura SM, Oki-Idouchi CE, Lorenzo PS (Nov 2006). "The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain". The Journal of Biological Chemistry. 281 (47): 36132–9. doi: 10.1074/jbc.M605093200 . PMID   17012239.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Randhawa PK, Rylova S, Heinz JY, Kiser S, Fried JH, Dunworth WP, Anderson AL, Barber AT, Chappell JC, Roberts DM, Bautch VL (May 2011). "The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration". Circulation Research. 108 (10): 1199–208. doi:10.1161/CIRCRESAHA.110.230888. PMC   3709466 . PMID   21474816.