RASSF5

RASSF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LGD, 4OH8
Identifiers
Aliases	RASSF5 , Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3, Ras association domain family member 5
External IDs	OMIM: 607020 MGI: 1926375 HomoloGene: 10296 GeneCards: RASSF5
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 206,507,531 bp [1] End 206,589,448 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 E4|1 56.91 cM Start 131,104,147 bp [2] End 131,172,995 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood thymus lymph node monocyte bone marrow appendix amniotic fluid spleen bone marrow cells thymus Top expressed in thymus spleen secondary oocyte blood motor neuron endocardial cushion bone marrow facial motor nucleus esophagus molar More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding identical protein binding Cellular component cytoplasm microtubule cytoskeleton nucleus Biological process intracellular signal transduction positive regulation of protein ubiquitination signal transduction negative regulation of cell population proliferation regulation of protein localization to nucleus apoptotic process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83593 54354 Ensembl ENSG00000266094 ENSMUSG00000026430 UniProt Q8WWW0 Q5EBH1 RefSeq (mRNA) NM_182665 NM_031437 NM_182663 NM_182664 NM_018750 NM_001311094 NM_001313731 RefSeq (protein) NP_872604 NP_872605 NP_872606 NP_001298023 NP_001300660 NP_061220 Location (UCSC) Chr 1: 206.51 – 206.59 Mb Chr 1: 131.1 – 131.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene. ^{[5] [6] [7]}

Function

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. ^[7]

Interactions

RASSF5 has been shown to interact with RRAS, ^[8] RAP2A, ^[8] MRAS ^[8] and RASSF1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000266094 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026430 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yao R, Wang Y, You M (Apr 2002). "Chromosome mapping and sequence variation of the murine Ras effector gene Nore1". Cytogenetics and Cell Genetics. 95 (1–2): 126–8. doi:10.1159/000057035. PMID   11978988. S2CID   26933977.
6. Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP (Apr 2002). "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1". Oncogene. 21 (17): 2713–20. doi: 10.1038/sj.onc.1205365 . PMID   11965544.
7. "Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5".
8. Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi: 10.1038/sj.onc.1205192 . PMID   11857081.

Further reading

• Kumari G, Singhal PK, Suryaraja R, Mahalingam S (Mar 2010). "Functional interaction of the Ras effector RASSF5 with the tyrosine kinase Lck: critical role in nucleocytoplasmic transport and cell cycle regulation". Journal of Molecular Biology. 397 (1): 89–109. doi:10.1016/j.jmb.2010.01.005. PMID   20064523.
• Vavvas D, Li X, Avruch J, Zhang XF (Mar 1998). "Identification of Nore1 as a potential Ras effector". The Journal of Biological Chemistry. 273 (10): 5439–42. doi: 10.1074/jbc.273.10.5439 . PMID   9488663.
• Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi: 10.1038/sj.onc.1205192 . PMID   11857081.
• Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J (Feb 2002). "Identification of a novel Ras-regulated proapoptotic pathway". Current Biology. 12 (4): 253–65. doi: 10.1016/S0960-9822(02)00683-8 . PMID   11864565. S2CID   14053233.
• Vos MD, Martinez A, Ellis CA, Vallecorsa T, Clark GJ (Jun 2003). "The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung". The Journal of Biological Chemistry. 278 (24): 21938–43. doi: 10.1074/jbc.M211019200 . PMID   12676952.
• Katagiri K, Maeda A, Shimonaka M, Kinashi T (Aug 2003). "RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1". Nature Immunology. 4 (8): 741–8. doi:10.1038/ni950. PMID   12845325. S2CID   10588415.
• Chen J, Lui WO, Vos MD, Clark GJ, Takahashi M, Schoumans J, Khoo SK, Petillo D, Lavery T, Sugimura J, Astuti D, Zhang C, Kagawa S, Maher ER, Larsson C, Alberts AS, Kanayama HO, Teh BT (Nov 2003). "The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas". Cancer Cell. 4 (5): 405–13. doi: 10.1016/S1535-6108(03)00269-1 . PMID   14667507.
• Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J (Jul 2004). "Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras". The Biochemical Journal. 381 (Pt 2): 453–62. doi:10.1042/BJ20040025. PMC   1133852 . PMID   15109305.
• Irimia M, Fraga MF, Sanchez-Cespedes M, Esteller M (Nov 2004). "CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer". Oncogene. 23 (53): 8695–9. doi: 10.1038/sj.onc.1207914 . PMID   15378027.
• Fujita H, Fukuhara S, Sakurai A, Yamagishi A, Kamioka Y, Nakaoka Y, Masuda M, Mochizuki N (Feb 2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". The Journal of Biological Chemistry. 280 (6): 5022–31. doi: 10.1074/jbc.M409701200 . PMID   15569673.
• Nakamura N, Carney JA, Jin L, Kajita S, Pallares J, Zhang H, Qian X, Sebo TJ, Erickson LA, Lloyd RV (Sep 2005). "RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors". Laboratory Investigation. 85 (9): 1065–75. doi: 10.1038/labinvest.3700306 . PMID   15980887.
• Foukakis T, Au AY, Wallin G, Geli J, Forsberg L, Clifton-Bligh R, Robinson BG, Lui WO, Zedenius J, Larsson C (Mar 2006). "The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARgamma fusion". The Journal of Clinical Endocrinology and Metabolism. 91 (3): 1143–9. doi: 10.1210/jc.2005-1372 . PMID   16352687.
• Moshnikova A, Frye J, Shay JW, Minna JD, Khokhlatchev AV (Mar 2006). "The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway". The Journal of Biological Chemistry. 281 (12): 8143–52. doi: 10.1074/jbc.M511837200 . PMID   16421102.
• Macheiner D, Heller G, Kappel S, Bichler C, Stättner S, Ziegler B, Kandioler D, Wrba F, Schulte-Hermann R, Zöchbauer-Müller S, Grasl-Kraupp B (Jul 2006). "NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma". Journal of Hepatology. 45 (1): 81–9. doi:10.1016/j.jhep.2005.12.017. PMID   16516329.
• Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R (Oct 2006). "Nore1B regulates TCR signaling via Ras and Carma1". Cellular Signalling. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMC   3204664 . PMID   16520020.