RAP2A

RAP2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KAO, 2RAP, 3RAP
Identifiers
Aliases	RAP2A , K-REV, KREV, RAP2, RbBP-30, member of RAS oncogene family
External IDs	OMIM: 179540; MGI: 97855; HomoloGene: 10875; GeneCards: RAP2A; OMA:RAP2A - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q32.1 Start 97,434,169 bp [1] End 97,469,128 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 E4|14 64.72 cM Start 120,715,856 bp [2] End 120,744,606 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons buccal mucosa cell internal globus pallidus superior vestibular nucleus subthalamic nucleus parietal lobe middle temporal gyrus Brodmann area 23 inferior ganglion of vagus nerve postcentral gyrus Top expressed in sciatic nerve Region I of hippocampus proper subiculum left lung lobe ventromedial nucleus barrel cortex anterior amygdaloid area optic nerve nucleus of stria terminalis primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding magnesium ion binding GTPase activity GTP binding GDP binding Cellular component recycling endosome cytosol endosome membrane plasma membrane recycling endosome membrane midbody Biological process actin cytoskeleton reorganization microvillus assembly positive regulation of protein phosphorylation establishment of protein localization Rap protein signal transduction regulation of dendrite morphogenesis regulation of JNK cascade negative regulation of cell migration establishment of epithelial cell apical/basal polarity positive regulation of protein autophosphorylation protein localization to plasma membrane signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5911 76108 Ensembl ENSG00000125249 ENSMUSG00000051615 UniProt P10114 Q80ZJ1 RefSeq (mRNA) NM_021033 NM_029519 RefSeq (protein) NP_066361 NP_083795 Location (UCSC) Chr 13: 97.43 – 97.47 Mb Chr 14: 120.72 – 120.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene. ^[5] RAP2A is a member of the Ras-related protein family.

Interactions

RAP2A has been shown to interact with RUNDC3A, ^[6] RASSF5 ^[7] and RALGDS. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000125249 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051615 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RAP2A RAP2A, member of RAS oncogene family".
6. Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry. 252 (2): 290–8. doi: 10.1046/j.1432-1327.1998.2520290.x . PMID   9523700.
7. Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID   11857081. S2CID   240243.
8. Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi: 10.1074/jbc.274.13.8737 . PMID   10085114.

Further reading

• Lerosey I, Chardin P, de Gunzburg J, Tavitian A (Mar 1991). "The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis". The Journal of Biological Chemistry. 266 (7): 4315–21. doi: 10.1016/S0021-9258(20)64324-1 . PMID   1900290.
• Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A (Aug 1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene. 3 (2): 201–4. PMID   3045729.
• Farrell FX, Yamamoto K, Lapetina EG (Jan 1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". The Biochemical Journal. 289 ( Pt 2) (Pt 2): 349–55. doi:10.1042/bj2890349. PMC   1132174 . PMID   8424780.
• Cherfils J, Ménétrey J, Le Bras G, Janoueix-Lerosey I, de Gunzburg J, Garel JR, Auzat I (Sep 1997). "Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS". The EMBO Journal. 16 (18): 5582–91. doi:10.1093/emboj/16.18.5582. PMC   1170190 . PMID   9312017.
• Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry. 252 (2): 290–8. doi: 10.1046/j.1432-1327.1998.2520290.x . PMID   9523700.
• Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi: 10.1074/jbc.274.13.8737 . PMID   10085114.
• Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C (May 1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". The Journal of Biological Chemistry. 274 (19): 13556–62. doi: 10.1074/jbc.274.19.13556 . PMID   10224125.
• Ménétrey J, Cherfils J (Nov 1999). "Structure of the small G protein Rap2 in a non-catalytic complex with GTP". Proteins. 37 (3): 465–73. doi: 10.1002/(SICI)1097-0134(19991115)37:3<465::AID-PROT13>3.0.CO;2-O . PMID   10591105.
• de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL (Jul 2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". The Journal of Biological Chemistry. 275 (27): 20829–36. doi: 10.1074/jbc.M001113200 . PMID   10777494.
• Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (Jul 2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience. 3 (7): 661–9. doi:10.1038/76615. hdl: 1842/742 . PMID   10862698. S2CID   14392630.
• Traver S, Bidot C, Spassky N, Baltauss T, De Tand MF, Thomas JL, Zalc B, Janoueix-Lerosey I, Gunzburg JD (Aug 2000). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao". The Biochemical Journal. 350 Pt 1 (Pt 1): 19–29. doi:10.1042/0264-6021:3500019. PMC   1221220 . PMID   10926822.
• Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". The Journal of Biological Chemistry. 276 (45): 42219–25. doi: 10.1074/jbc.M105760200 . PMID   11524421.
• Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID   11857081. S2CID   240243.
• Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T (Nov 2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID   12444546. S2CID   13499744.
• Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ (Feb 2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1593 (2–3): 141–9. doi:10.1016/S0167-4889(02)00365-8. PMID   12581858.
• Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Taira K, Uezato H, Ogawa Y, Kariya K (Apr 2004). "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase". The Journal of Biological Chemistry. 279 (16): 15711–4. doi: 10.1074/jbc.C300542200 . PMID   14966141.
• Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". The Journal of Biological Chemistry. 279 (21): 22353–61. doi: 10.1074/jbc.M312867200 . PMID   15031288.