RB1CC1

RB1CC1
Identifiers
Aliases	RB1CC1 , ATG17, CC1, FIP200, PPP1R131, RB1 inducible coiled-coil 1
External IDs	OMIM: 606837; MGI: 1341850; HomoloGene: 7659; GeneCards: RB1CC1; OMA:RB1CC1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q11.23 Start 52,622,458 bp [1] End 52,745,843 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 A1 Start 6,206,197 bp [2] End 6,276,648 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell bronchial epithelial cell caput epididymis postcentral gyrus corpus epididymis biceps brachii tail of epididymis jejunal mucosa Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii Top expressed in spermatocyte spermatid zygote morula genital tubercle muscle of thigh granulocyte tail of embryo dentate gyrus of hippocampal formation granule cell secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding molecular adaptor activity Cellular component phagophore assembly site membrane nuclear membrane Atg1/ULK1 kinase complex phagophore assembly site nucleus cytoplasm endoplasmic reticulum membrane cytosol extrinsic component of membrane lysosome Biological process positive regulation of protein phosphorylation regulation of transcription, DNA-templated negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process autophagosome assembly transcription, DNA-templated heart development positive regulation of cell size cell cycle liver development macroautophagy autophagy positive regulation of JNK cascade autophagy of mitochondrion autophagy of peroxisome reticulophagy glycophagy regulation of macroautophagy piecemeal microautophagy of the nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9821 12421 Ensembl ENSG00000023287 ENSMUSG00000025907 UniProt Q8TDY2 Q9ESK9 RefSeq (mRNA) NM_001083617 NM_014781 NM_009826 RefSeq (protein) NP_001077086 NP_055596 NP_033956 Location (UCSC) Chr 8: 52.62 – 52.75 Mb Chr 1: 6.21 – 6.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RB1-inducible coiled-coil protein 1 is a protein that in humans is encoded by the RB1CC1 gene. ^{[5] [6] [7] [8]}

Interactions

RB1CC1 has been shown to interact with PTK2B, ^[9] ASK1 ^[10] and PTK2. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000023287 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025907 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chano T, Ikegawa S, Kontani K, Okabe H, Baldini N, Saeki Y (Feb 2002). "Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells". Oncogene. 21 (8): 1295–8. doi: 10.1038/sj.onc.1205171 . PMID   11850849. S2CID   1446211.
6. Maucuer A, Camonis JH, Sobel A (Apr 1995). "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains". Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3100–4. Bibcode:1995PNAS...92.3100M. doi: 10.1073/pnas.92.8.3100 . PMC   42112 . PMID   7724523.
7. Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N (May 2008). "FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells". The Journal of Cell Biology. 181 (3): 497–510. doi:10.1083/jcb.200712064. PMC   2364687 . PMID   18443221.
8. "Entrez Gene: RB1CC1 RB1-inducible coiled-coil 1".
9. Ueda H, Abbi S, Zheng C, Guan JL (Apr 2000). "Suppression of Pyk2 kinase and cellular activities by FIP200". The Journal of Cell Biology. 149 (2): 423–30. doi:10.1083/jcb.149.2.423. PMC   2175150 . PMID   10769033.
10. Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL (Oct 2006). "Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways". The Journal of Cell Biology. 175 (1): 121–33. doi:10.1083/jcb.200604129. PMC   2064504 . PMID   17015619.

Further reading

• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Oct 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID   9039502.
• Ueda H, Abbi S, Zheng C, Guan JL (Apr 2000). "Suppression of Pyk2 kinase and cellular activities by FIP200". The Journal of Cell Biology. 149 (2): 423–30. doi:10.1083/jcb.149.2.423. PMC   2175150 . PMID   10769033.
• Chano T, Kontani K, Teramoto K, Okabe H, Ikegawa S (Jul 2002). "Truncating mutations of RB1CC1 in human breast cancer". Nature Genetics. 31 (3): 285–8. doi:10.1038/ng911. PMID   12068296. S2CID   23884140.
• Chano T, Ikegawa S, Saito-Ohara F, Inazawa J, Mabuchi A, Saeki Y, Okabe H (May 2002). "Isolation, characterization and mapping of the mouse and human RB1CC1 genes". Gene. 291 (1–2): 29–34. doi:10.1016/S0378-1119(02)00585-1. PMID   12095676.
• Chano T, Saeki Y, Serra M, Matsumoto K, Okabe H (Aug 2002). "Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells". The American Journal of Pathology. 161 (2): 359–64. doi:10.1016/S0002-9440(10)64190-9. PMC   1850752 . PMID   12163359.
• Abbi S, Ueda H, Zheng C, Cooper LA, Zhao J, Christopher R, Guan JL (Sep 2002). "Regulation of focal adhesion kinase by a novel protein inhibitor FIP200". Molecular Biology of the Cell. 13 (9): 3178–91. doi:10.1091/mbc.E02-05-0295. PMC   124151 . PMID   12221124.
• Kontani K, Chano T, Ozaki Y, Tezuka N, Sawai S, Fujino S, Saeki Y, Okabe H (Nov 2003). "RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells". International Journal of Molecular Medicine. 12 (5): 767–9. doi:10.3892/ijmm.12.5.767. PMID   14533007.
• Bamba N, Chano T, Taga T, Ohta S, Takeuchi Y, Okabe H (Oct 2004). "Expression and regulation of RB1CC1 in developing murine and human tissues". International Journal of Molecular Medicine. 14 (4): 583–7. doi:10.3892/ijmm.14.4.583. PMID   15375585.
• Watanabe R, Chano T, Inoue H, Isono T, Koiwai O, Okabe H (Sep 2005). "Rb1cc1 is critical for myoblast differentiation through Rb1 regulation". Virchows Archiv. 447 (3): 643–8. doi:10.1007/s00428-004-1183-1. PMID   15968549. S2CID   21517958.
• Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL (Aug 2005). "Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control". The Journal of Cell Biology. 170 (3): 379–89. doi:10.1083/jcb.200411106. PMC   2171462 . PMID   16043512.
• Melkoumian ZK, Peng X, Gan B, Wu X, Guan JL (Aug 2005). "Mechanism of cell cycle regulation by FIP200 in human breast cancer cells". Cancer Research. 65 (15): 6676–84. doi: 10.1158/0008-5472.CAN-04-4142 . PMID   16061648.
• Chano T, Saji M, Inoue H, Minami K, Kobayashi T, Hino O, Okabe H (Sep 2006). "Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation". International Journal of Molecular Medicine. 18 (3): 425–32. doi: 10.3892/ijmm.18.3.425 . PMID   16865226.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Lee YC, Yang VC, Wang TS (Sep 2007). "Use of RAPD to detect sodium arsenite-induced DNA damage in human lymphoblastoid cells". Toxicology. 239 (1–2): 108–15. doi:10.1016/j.tox.2007.06.101. PMID   17707572.