RBM12

RBM12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WEL, 2CPY, 2DNN, 2EK1, 2EK6
Identifiers
Aliases	RBM12 , HRIHFB2091, SWAN, RNA binding motif protein 12, SCZD19
External IDs	OMIM: 607179; MGI: 1922960; HomoloGene: 34993; GeneCards: RBM12; OMA:RBM12 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.22 Start 35,648,925 bp [1] End 35,664,956 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 155,933,878 bp [2] End 155,953,898 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon secondary oocyte bone marrow cells embryo ganglionic eminence islet of Langerhans amniotic fluid ventricular zone cartilage tissue Top expressed in primitive streak tail of embryo genital tubercle abdominal wall aortic valve mandibular prominence maxillary prominence ureter hair follicle somite More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10137 75710 Ensembl ENSG00000244462 ENSMUSG00000089824 UniProt Q9NTZ6 Q8R4X3 RefSeq (mRNA) NM_152838 NM_001198838 NM_001198840 NM_006047 NM_029397 NM_170598 RefSeq (protein) NP_001185767 NP_001185769 NP_006038 NP_690051 NP_083673 NP_733486 Location (UCSC) Chr 20: 35.65 – 35.66 Mb Chr 2: 155.93 – 155.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RNA-binding protein 12 is a protein that in humans is encoded by the RBM12 gene. ^{[5] [6]}

This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in two transcript variants. Both variants encode the same protein. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000244462 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000089824 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stover C, Gradl G, Jentsch I, Speicher MR, Wieser R, Schwaeble W (Jul 2001). "cDNA cloning, chromosome assignment, and genomic structure of a human gene encoding a novel member of the RBM family". Cytogenet Cell Genet. 92 (3–4): 225–30. doi:10.1159/000056908. PMID   11435693. S2CID   20555964.
6. "Entrez Gene: RBM12 RNA binding motif protein 12".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Kofler M, Motzny K, Freund C (2006). "GYF domain proteomics reveals interaction sites in known and novel target proteins". Mol. Cell. Proteomics. 4 (11): 1797–811. doi: 10.1074/mcp.M500129-MCP200 . PMID   16120600.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID   9872452.
• Ueki N, Oda T, Kondo M, et al. (1999). "Selection system for genes encoding nuclear-targeted proteins". Nat. Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID   9853615. S2CID   20001769.

External links

• RBM12 human gene location in the UCSC Genome Browser .
• RBM12 human gene details in the UCSC Genome Browser .