RBP1

RBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5HA1, 5HBS, 5H8T, 5H9A
Identifiers
Aliases	RBP1 , CRABP-I, CRBP, CCRBPI, RBPC, retinol binding protein 1
External IDs	OMIM: 180260; MGI: 97876; HomoloGene: 2175; GeneCards: RBP1; OMA:RBP1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q23 Start 139,517,434 bp [1] End 139,539,829 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 E3.3|9 51.36 cM Start 98,305,014 bp [2] End 98,328,628 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium right uterine tube body of pancreas left ovary right adrenal gland right adrenal cortex anterior pituitary left adrenal gland left adrenal cortex decidua Top expressed in choroid plexus of fourth ventricle vestibular sensory epithelium optic nerve retinal pigment epithelium medial ganglionic eminence endocardial cushion efferent ductule lactiferous gland external carotid artery internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding retinol binding retinoid binding retinal binding all-trans-retinol binding Cellular component nucleoplasm cytoplasm cytosol lipid droplet Biological process retinoic acid biosynthetic process retinoid metabolic process vitamin A metabolic process lipid homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5947 19659 Ensembl ENSG00000114115 ENSMUSG00000046402 UniProt P09455 Q00915 RefSeq (mRNA) NM_002899 NM_001130992 NM_001130993 NM_001365940 NM_011254 RefSeq (protein) NP_001124464 NP_001124465 NP_002890 NP_001352869 NP_035384 Location (UCSC) Chr 3: 139.52 – 139.54 Mb Chr 9: 98.31 – 98.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene. ^{[5] [6] [7]}

Function

RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues, respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene. ^[5]

Clinical significance

Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiative state of endometrial cells through the regulation of bioavailability of retinol. On the converse, loss of CRBP-1 is associated with development of endometrial cancer. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000114115 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046402 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RBP1 retinol binding protein 1, cellular".
6. Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ (September 1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. doi: 10.1016/S0021-9258(19)47422-X . PMID   1654334.
7. De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L (1998). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 226–7. doi:10.1159/000015107. PMID   9858824. S2CID   46851294.
8. Orlandi A, Ferlosio A, Ciucci A, Francesconi A, Lifschitz-Mercer B, Gabbiani G, Spagnoli LG, Czernobilsky B (June 2006). "Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications". Mod. Pathol. 19 (6): 797–803. doi: 10.1038/modpathol.3800586 . PMID   16575402.

Further reading

• Herr FM, Ong DE (1992). "Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins". Biochemistry. 31 (29): 6748–55. doi:10.1021/bi00144a014. PMID   1322170.
• Siegenthaler G, Tomatis I, Chatellard-Gruaz D, et al. (1992). "Expression of CRABP-I and -II in human epidermal cells. Alteration of relative protein amounts is linked to the state of differentiation". Biochem. J. 287. ( Pt 2) (2): 383–9. doi:10.1042/bj2870383. PMC   1133176 . PMID   1332671.
• Aström A, Tavakkol A, Pettersson U, et al. (1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. doi: 10.1016/S0021-9258(19)47422-X . PMID   1654334.
• Wei LN, Mertz JR, Goodman DS, Nguyen-Huu MC (1990). "Cellular retinoic acid- and cellular retinol-binding proteins: complementary deoxyribonucleic acid cloning, chromosomal assignment, and tissue specific expression". Mol. Endocrinol. 1 (8): 526–34. doi: 10.1210/mend-1-8-526 . PMID   2856408.
• Colantuoni V, Cortese R, Nilsson M, et al. (1985). "Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein". Biochem. Biophys. Res. Commun. 130 (1): 431–9. doi:10.1016/0006-291X(85)90435-8. PMID   2992469.
• Nilsson MH, Spurr NK, Lundvall J, et al. (1988). "Human cellular retinol-binding protein gene organization and chromosomal location". Eur. J. Biochem. 173 (1): 35–44. doi: 10.1111/j.1432-1033.1988.tb13963.x . PMID   3356192.
• Sherman DR, Lloyd RS, Chytil F (1987). "Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3209–13. Bibcode:1987PNAS...84.3209S. doi: 10.1073/pnas.84.10.3209 . PMC   304838 . PMID   3472205.
• Kooistra T, Lansink M, Arts J, et al. (1995). "Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells". Eur. J. Biochem. 232 (2): 425–32. doi: 10.1111/j.1432-1033.1995.425zz.x . PMID   7556191.
• Jaconi S, Rose K, Hughes GJ, et al. (1995). "Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure". J. Lipid Res. 36 (6): 1247–53. doi: 10.1016/S0022-2275(20)41132-0 . PMID   7666002.
• Liu W, Hellman P, Li Q, et al. (1997). "Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells". Biochem. Biophys. Res. Commun. 229 (3): 922–9. doi:10.1006/bbrc.1996.1903. PMID   9005841.
• Sundaram M, Sivaprasadarao A, DeSousa MM, Findlay JB (1998). "The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane receptor". J. Biol. Chem. 273 (6): 3336–42. doi: 10.1074/jbc.273.6.3336 . PMID   9452451.
• De Baere E, Speleman F, Van Roy N, et al. (1999). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 226–7. doi:10.1159/000015107. PMID   9858824. S2CID   46851294.
• Christensen EI, Moskaug JO, Vorum H, et al. (1999). "Evidence for an essential role of megalin in transepithelial transport of retinol". J. Am. Soc. Nephrol. 10 (4): 685–95. doi: 10.1681/ASN.V104685 . PMID   10203351.
• Skowyra D, Zeremski M, Neznanov N, et al. (2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex". J. Biol. Chem. 276 (12): 8734–9. doi: 10.1074/jbc.M007664200 . PMID   11118440.
• Folli C, Calderone V, Ottonello S, et al. (2001). "Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3710–5. Bibcode:2001PNAS...98.3710F. doi: 10.1073/pnas.061455898 . PMC   31117 . PMID   11274389.
• Orlandi A, Francesconi A, Clément S, et al. (2002). "High levels of cellular retinol binding protein-1 expression in leiomyosarcoma: possible implications for diagnostic evaluation". Virchows Arch. 441 (1): 31–40. doi:10.1007/s00428-001-0576-7. PMID   12111198. S2CID   195243470.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cvetković D, Williams SJ, Hamilton TC (2003). "Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer". Clin. Cancer Res. 9 (3): 1013–20. PMID   12631600.
• Hosaka B, Park SI, Felipe CR, et al. (2004). "Predictive value of urinary retinol binding protein for graft dysfunction after kidney transplantation". Transplant. Proc. 35 (4): 1341–3. doi:10.1016/S0041-1345(03)00380-4. PMID   12826154.
• Schmitt-Gräff A, Ertelt V, Allgaier HP, et al. (2003). "Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival". Hepatology. 38 (2): 470–80. doi: 10.1053/jhep.2003.50321 . PMID   12883492. S2CID   23904734.