| RCAN2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | RCAN2 , CSP2, DSCR1L1, MCIP2, RCN2, ZAKI-4, ZAKI4, regulator of calcineurin 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604876 MGI: 1858219 HomoloGene: 130985 GeneCards: RCAN2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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RCAN2 is a gene that in humans encodes for the protein Calcipressin-2.
Calcipressin-2 is a protein that in humans is encoded by the RCAN2 gene. [5] [6]
N/A
Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase. It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of the T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which include ciclosporin, voclosporin, pimecrolimus and tacrolimus.
Angiogenin (ANG) also known as ribonuclease 5 is a small 123 amino acid protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator of new blood vessels through the process of angiogenesis. Ang hydrolyzes cellular RNA, resulting in modulated levels of protein synthesis and interacts with DNA causing a promoter-like increase in the expression of rRNA. Ang is associated with cancer and neurological disease through angiogenesis and through activating gene expression that suppresses apoptosis.
Clarin-1 is a protein that in humans is encoded by the CLRN1 gene.
Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene. It is a member of the adhesion-GPCR family of receptors.
Collagen alpha-1(XVIII) chain is a protein that in humans is encoded by the COL18A1 gene.
Down syndrome critical region gene 1, also known as DSCR1, is a protein that in humans is encoded by the RCAN1 gene.
Carbonic anhydrase-related protein 10 is an enzyme that in humans is encoded by the CA10 gene.
BAI1-associated protein 3 is a protein that in humans is encoded by the BAIAP3 gene.
ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a protein that in humans is encoded by the ABI3 gene.
Coiled-coil and C2 domain-containing protein 1A is a protein that in humans is encoded by the CC2D1A gene.
Centromere protein T is a protein that in humans is encoded by the CENPT gene.
A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.
T-box transcription factor TBX22 is a protein that in humans is encoded by the TBX22 gene.
39S ribosomal protein L40, mitochondrial is a protein that in humans is encoded by the MRPL40 gene.
Proteasome assembly chaperone 1 is a protein that in humans is encoded by the PSMG1 gene.
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PP2BA) is a protein that in humans is encoded by the PPP3CA gene.
Subunit P of phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the PIGP gene.
WAP four-disulfide core domain protein 1 is a protein that in humans is encoded by the WFDC1 gene.
RCAN3 is a gene that in humans encodes the Calcipressin-3 protein.
In molecular biology, the calcipressin family of proteins negatively regulate calcineurin by direct binding. They are essential for the survival of T helper type 1 cells. Calcipressin 1 is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the conserved FLISPP motif; this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation.
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