RCAN2

RCAN2
Identifiers
Aliases	RCAN2 , CSP2, DSCR1L1, MCIP2, RCN2, ZAKI-4, ZAKI4, regulator of calcineurin 2
External IDs	OMIM: 604876; MGI: 1858219; HomoloGene: 130985; GeneCards: RCAN2; OMA:RCAN2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p12.3 Start 46,220,736 bp [1] End 46,491,972 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 B3|17 19.77 cM Start 44,112,242 bp [2] End 44,350,407 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pars compacta pars reticulata Pons right ventricle middle temporal gyrus endothelial cell external globus pallidus Brodmann area 23 superior vestibular nucleus Top expressed in interventricular septum extraocular muscle motor neuron superior colliculus right ventricle myocardium of ventricle cardiac muscles molar central gray substance of midbrain medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-dependent protein serine/threonine phosphatase regulator activity nucleic acid binding Cellular component cytoplasm cellular component Biological process regulation of calcineurin-NFAT signaling cascade calcium-mediated signaling regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10231 53901 Ensembl ENSG00000172348 ENSMUSG00000039601 UniProt Q14206 Q9JHG2 RefSeq (mRNA) NM_001251973 NM_001251974 NM_005822 NM_001286653 NM_001286654 NM_030598 NM_207649 NM_001357742 RefSeq (protein) NP_001238902 NP_001238903 NP_005813 NP_001273582 NP_001273583 NP_085101 NP_997532 NP_001344671 Location (UCSC) Chr 6: 46.22 – 46.49 Mb Chr 17: 44.11 – 44.35 Mb PubMed search [3] [4]
Wikidata
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RCAN2 is a gene that in humans encodes for the protein Calcipressin-2.

Calcipressin-2 is a protein that in humans is encoded by the RCAN2 gene. ^{[5] [6]}

See also

• RCAN1
• RCAN3

References

1. GRCh38: Ensembl release 89: ENSG00000172348 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039601 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyazaki T, Kanou Y, Murata Y, Ohmori S, Niwa T, Maeda K, Yamamura H, Seo H (Aug 1996). "Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts". J Biol Chem. 271 (24): 14567–71. doi: 10.1074/jbc.271.24.14567 . PMID   8662924.
6. "Entrez Gene: DSCR1L1 Down syndrome critical region gene 1-like 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Rothermel B, Vega RB, Yang J, et al. (2000). "A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling". J. Biol. Chem. 275 (12): 8719–25. doi: 10.1074/jbc.275.12.8719 . PMID   10722714.
• Strippoli P, Lenzi L, Petrini M, et al. (2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)". Genomics. 64 (3): 252–63. doi:10.1006/geno.2000.6127. PMID   10756093.
• Fuentes JJ, Genescà L, Kingsbury TJ, et al. (2000). "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways". Hum. Mol. Genet. 9 (11): 1681–90. doi: 10.1093/hmg/9.11.1681 . PMID   10861295.
• Cao X, Kambe F, Miyazaki T, et al. (2002). "Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors". Biochem. J. 367 (Pt 2): 459–66. doi:10.1042/BJ20011797. PMC   1222895 . PMID   12102656.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Qin L, Zhao D, Liu X, et al. (2007). "Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway". Mol. Cancer Res. 4 (11): 811–20. doi: 10.1158/1541-7786.MCR-06-0126 . PMID   17114339.
• Gollogly LK, Ryeom SW, Yoon SS (2007). "Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis". J. Surg. Res. 142 (1): 129–36. doi:10.1016/j.jss.2006.10.011. PMC   1995402 . PMID   17610901.

External links

• RCAN2 human gene location in the UCSC Genome Browser .
• RCAN2 human gene details in the UCSC Genome Browser .