RCBTB1

RCBTB1
Identifiers
Aliases	RCBTB1 , CLLD7, CLLL7, GLP, RCC1 and BTB domain containing protein 1, RDEOA
External IDs	OMIM: 607867 MGI: 1918580 HomoloGene: 10061 GeneCards: RCBTB1
Gene location (Mouse) Chr. Chromosome 14 (mouse) [1] Band 14|14 C3 Start 59,438,658 bp [1] End 59,474,714 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in submandibular gland ganglionic eminence globus pallidus ventral tegmental area pineal gland hand pontine nuclei left lobe of liver crypt of lieberkuhn of small intestine abdominal wall BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 55213 71330 Ensembl ENSG00000136144 ENSMUSG00000035469 UniProt Q8NDN9 Q6NXM2 RefSeq (mRNA) NM_018191 NM_027764 NM_001360610 NM_001360611 RefSeq (protein) NP_060661 NP_001339429 NP_001339430 NP_001339431 NP_001339432 NP_001339433 NP_001339434 NP_001339435 NP_082040 NP_001347539 NP_001347540 Location (UCSC) n/a Chr 14: 59.44 – 59.47 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

RCC1 and BTB domain-containing protein 1 is a protein that in humans is encoded by the RCBTB1 gene. ^{[4] [5]}

This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rats, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. The C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. ^[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000035469 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mabuchi H, Fujii H, Calin G, Alder H, Negrini M, Rassenti L, Kipps TJ, Bullrich F, Croce CM (Apr 2001). "Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia". Cancer Res. 61 (7): 2870–7. PMID   11306461.
5. "Entrez Gene: RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Solomou EE, Sfikakis PP, Kotsi P, et al. (2004). "13q deletion in chronic lymphocytic leukemia: characterization of E4.5, a novel chromosome condensation regulator-like guanine nucleotide exchange factor". Leuk. Lymphoma. 44 (9): 1579–85. doi:10.3109/10428190309178782. PMID   14565662. S2CID   41439989.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Guo DF, Tardif V, Ghelima K, et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells". J. Biol. Chem. 279 (20): 21109–20. doi: 10.1074/jbc.M401544200 . PMID   14985364.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.