Retinol dehydrogenase 10 is an enzyme that in humans is encoded by the RDH10 gene on chromosome 8.
Retinol dehydrogenase 10 is an enzyme that in humans is encoded by the RDH10 gene on chromosome 8.
| Retinol dehydrogenase 10 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.105 | ||||||||
| Alt. names | NAD+-retinol dehydrogenase | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
RDH10 is a membrane-bound NAD +-dependent retinol dehydrogenase which belongs to the superfamily of short-chain dehydrogenases. [5] [6] [7] RDH10 catalyzes the first oxidative step in retinoic acid biosynthesis: [8]
Due to its preference for NAD+ rather than NADP+ as a cofactor, RDH10 functions near-exclusively in the oxidative direction under physiological conditions to increase levels of retinal and retinoic acid. [5]
RDH10 has also been shown to act on 11-cis-retinol via interactions with CRALBP and RPE65. [9]
RDH10 plays an essential role in organ, limb, and craniofacial development during embryogenesis. [10]
RDH10 loss of function mutations in mice are embryonically lethal. [11] Despite its similarity to other retinol dehydrogenases, RDH10 is not associated with any known human retinal disease. RDH10 may partially compensate for loss of RDH5 function in fundus albipunctatus. [9] RDH10 overexpression is associated with brain and spinal cord glioma progression. [12] Serum levels of RDH10 may serve as a biomarker for type 2 diabetes or metabolic dysfunction–associated steatotic liver disease. [13]
{{cite journal}}: CS1 maint: article number as page number (link)  | This gene article is a stub. You can help Wikipedia by expanding it. |