REPS1

REPS1
Identifiers
Aliases	REPS1 , RALBP1, RALBP1 associated Eps domain containing 1, NBIA7
External IDs	OMIM: 614825; MGI: 1196373; HomoloGene: 7515; GeneCards: REPS1; OMA:REPS1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q24.1 Start 138,903,493 bp [1] End 138,988,261 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A3 Start 17,931,609 bp [2] End 18,000,903 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone right uterine tube parotid gland olfactory zone of nasal mucosa anterior pituitary ganglionic eminence right hemisphere of cerebellum Brodmann area 9 skin of abdomen right frontal lobe Top expressed in genital tubercle tail of embryo secondary oocyte zygote submandibular gland spermatocyte gastrula primary oocyte Rostral migratory stream seminal vesicula More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding SH3 domain binding protein binding metal ion binding Cellular component membrane plasma membrane clathrin-coated pit cytosol Biological process receptor-mediated endocytosis membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85021 19707 Ensembl ENSG00000135597 ENSMUSG00000019854 UniProt Q96D71 O54916 RefSeq (mRNA) NM_001128617 NM_001286611 NM_001286612 NM_031922 NM_001111065 NM_009048 RefSeq (protein) NP_001122089 NP_001273540 NP_001273541 NP_114128 NP_001104535 NP_033074 Location (UCSC) Chr 6: 138.9 – 138.99 Mb Chr 10: 17.93 – 18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RalBP1-associated Eps domain-containing protein 1 is a protein that in humans is encoded by the REPS1 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000135597 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019854 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: REPS1 RALBP1 associated Eps domain containing 1".

Further reading

• Cantor SB, Urano T, Feig LA (1995). "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases". Mol. Cell. Biol. 15 (8): 4578–84. doi:10.1128/mcb.15.8.4578. PMC   230698 . PMID   7623849.
• Yamaguchi A, Urano T, Goi T, Feig LA (1998). "An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1". J. Biol. Chem. 272 (50): 31230–4. doi: 10.1074/jbc.272.50.31230 . PMID   9395447.
• Ikeda M, Ishida O, Hinoi T, et al. (1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J. Biol. Chem. 273 (2): 814–21. doi: 10.1074/jbc.273.2.814 . PMID   9422736.
• Xu J, Zhou Z, Zeng L, et al. (2002). "Cloning, expression and characterization of a novel human REPS1 gene". Biochim. Biophys. Acta. 1522 (2): 118–21. doi:10.1016/s0167-4781(01)00310-4. PMID   11750063.
• Cullis DN, Philip B, Baleja JD, Feig LA (2003). "Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors". J. Biol. Chem. 277 (51): 49158–66. doi: 10.1074/jbc.M206316200 . PMID   12364336.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hu Y, Mivechi NF (2003). "HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo". J. Biol. Chem. 278 (19): 17299–306. doi: 10.1074/jbc.M300788200 . PMID   12621024.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Drake KJ, Singhal J, Yadav S, et al. (2007). "RALBP1/RLIP76 mediates multidrug resistance". Int. J. Oncol. 30 (1): 139–44. doi: 10.3892/ijo.30.1.139 . PMID   17143522.
• Singhal SS, Singhal J, Nair MP, et al. (2007). "Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer". Int. J. Oncol. 30 (3): 717–25. doi: 10.3892/ijo.30.3.717 . PMID   17273774.