REPS2

REPS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IQ3
Identifiers
Aliases	REPS2 , POB1, RALBP1 associated Eps domain containing 2
External IDs	OMIM: 300317; MGI: 2663511; HomoloGene: 31255; GeneCards: REPS2; OMA:REPS2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	17,153,272 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	161,426,645 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; corpus epididymis; ; lateral nuclear group of thalamus; ; Brodmann area 23; ; postcentral gyrus; ; sural nerve; ; superior frontal gyrus; ; blood; ; pons; ; corpus callosum;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; subiculum; ; olfactory tubercle; ; primary motor cortex; ; mammillary body; ; anterior amygdaloid area; ; inferior colliculi; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding ; protein binding ; metal ion binding ;
Cellular component	cytoplasm ; cytosol ;
Biological process	epidermal growth factor receptor signaling pathway ; membrane organization ; protein-containing complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	9185
	194590
	ENSG00000169891
	ENSMUSG00000040855
	Q8NFH8
	Q80XA6
	NM_001080975 ; NM_004726
	NM_001290633 ; NM_178256 ; NM_001359102 ; NM_001359103 ; NM_001359104 Contents Function ; Interactions ; References ; Further reading ;
	NP_001074444 ; NP_004717
NP_001277562 ; NP_839987 ; NP_001346031 ; NP_001346032 ; NP_001346033 ;
	NP_001390994 ; NP_001390995 ; NP_001390996 ; NP_001390997 ; NP_001390998
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 16, 2024

RalBP1-associated Eps domain-containing protein 2 is a protein that in humans is encoded by the REPS2 gene.^[5]^[6]^[7]

Function

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

REPS2 has been shown to interact with EPN1,^[8] EPS15 ^[9] and RALBP1.^[5]

Related Research Articles

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Axin-1 is a protein that in humans is encoded by the AXIN1 gene.

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.

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Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.

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Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2. This protein is one of two paralogs of the Ral protein, the other being RalA, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169891 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040855 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A (February 1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J Biol Chem. 273 (2): 814–21. doi: 10.1074/jbc.273.2.814 . PMID 9422736.
↑ Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S (February 1999). "Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)". FEBS Lett. 442 (2–3): 138–42. doi: 10.1016/S0014-5793(98)01644-5 . PMID 9928989.
1 2 "Entrez Gene: REPS2 RALBP1 associated Eps domain containing 2".
↑ Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (October 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078. S2CID 23390428.
↑ Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A (July 1999). "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. doi:10.1093/emboj/18.13.3629. PMC 1171441 . PMID 10393179.

Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A (1999). "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. doi:10.1093/emboj/18.13.3629. PMC 1171441 . PMID 10393179.
Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078. S2CID 23390428.
Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. doi: 10.1074/jbc.M112472200 . PMID 11882656.
Oshiro T, Koyama S, Sugiyama S, Kondo A, Onodera Y, Asahara T, Sabe H, Kikuchi A (2002). "Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration". J. Biol. Chem. 277 (41): 38618–26. doi: 10.1074/jbc.M203453200 . PMID 12149250.
Oosterhoff JK, Penninkhof F, Brinkmann AO, Anton Grootegoed J, Blok LJ (2003). "REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells". Oncogene. 22 (19): 2920–5. doi:10.1038/sj.onc.1206397. PMID 12771942. S2CID 22877286.
Rossé C, L'Hoste S, Offner N, Picard A, Camonis J (2003). "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis". J. Biol. Chem. 278 (33): 30597–604. doi: 10.1074/jbc.M302191200 . PMID 12775724.
Penninkhof F, Grootegoed JA, Blok LJ (2004). "Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells" (PDF). Oncogene. 23 (33): 5607–15. doi: 10.1038/sj.onc.1207750 . PMID 15184881.
Oosterhoff JK, Kühne LC, Grootegoed JA, Blok LJ (2005). "EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2". Int. J. Cancer. 113 (4): 561–7. doi:10.1002/ijc.20612. PMID 15455380. S2CID 6956264.
Yadav S, Zajac E, Singhal SS, Singhal J, Drake K, Awasthi YC, Awasthi S (2005). "POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis". Biochem. Biophys. Res. Commun. 328 (4): 1003–9. doi:10.1016/j.bbrc.2005.01.055. PMID 15707977.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169891 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040855 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9422736-5] 1 2 Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A (February 1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J Biol Chem. 273 (2): 814–21. doi: 10.1074/jbc.273.2.814 . PMID 9422736.

[pmid9928989-6] Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S (February 1999). "Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)". FEBS Lett. 442 (2–3): 138–42. doi: 10.1016/S0014-5793(98)01644-5 . PMID 9928989.

[entrez-7] 1 2 "Entrez Gene: REPS2 RALBP1 associated Eps domain containing 2".

[pmid10557078-8] Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (October 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078. S2CID 23390428.

[pmid10393179-9] Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A (July 1999). "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. doi:10.1093/emboj/18.13.3629. PMC 1171441 . PMID 10393179.

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REPS2

Contents

Function

Interactions

Related Research Articles

References

Further reading