EPN1

EPN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1INZ
Identifiers
Aliases	EPN1 , epsin 1
External IDs	OMIM: 607262; MGI: 1333763; HomoloGene: 32172; GeneCards: EPN1; OMA:EPN1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.42 Start 55,675,226 bp [1] End 55,709,858 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A1 Start 5,080,235 bp [2] End 5,098,178 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart body of stomach mucosa of transverse colon right frontal lobe right auricle of heart anterior cingulate cortex left testis muscle of thigh right testis body of pancreas Top expressed in Ileal epithelium perirhinal cortex CA3 field entorhinal cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell lactiferous gland choroid plexus of fourth ventricle ankle joint More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding lipid binding Cellular component cytoplasm plasma membrane clathrin-coated pit membrane nucleus cytosol Biological process Notch signaling pathway female pregnancy negative regulation of epidermal growth factor receptor signaling pathway in utero embryonic development endocytosis embryonic organ development membrane organization negative regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29924 13854 Ensembl ENSG00000063245 ENSMUSG00000035203 UniProt Q9Y6I3 Q80VP1 RefSeq (mRNA) NM_001130071 NM_001130072 NM_013333 NM_001321263 NM_001252454 NM_010147 RefSeq (protein) NP_001123543 NP_001123544 NP_001308192 NP_037465 NP_001239383 NP_034277 NP_001359429 Location (UCSC) Chr 19: 55.68 – 55.71 Mb Chr 7: 5.08 – 5.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Epsin-1 is a protein that in humans is encoded by the EPN1 gene. ^{[5] [6] [7]}

EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM] ^[7]

Interactions

EPN1 has been shown to interact with REPS2, ^[6] AP2A2 ^[5] and EPS15. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000063245 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035203 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Sep 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. Bibcode:1998Natur.394..793C. doi:10.1038/29555. PMID   9723620. S2CID   4430975.
6. Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (Dec 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi: 10.1038/sj.onc.1202974 . PMID   10557078.
7. "Entrez Gene: EPN1 epsin 1".

Further reading

• Drake MT, Downs MA, Traub LM (2000). "Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites" (PDF). J. Biol. Chem. 275 (9): 6479–89. doi: 10.1074/jbc.275.9.6479 . PMID   10692452. S2CID   22584410.
• Kariya K, Koyama S, Nakashima S, et al. (2000). "Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation". J. Biol. Chem. 275 (24): 18399–406. doi: 10.1074/jbc.M000521200 . PMID   10764745.
• Hyman J, Chen H, Di Fiore PP, et al. (2000). "Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)". J. Cell Biol. 149 (3): 537–46. doi:10.1083/jcb.149.3.537. PMC   2174850 . PMID   10791968.
• Drake MT, Traub LM (2001). "Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller". J. Biol. Chem. 276 (31): 28700–9. doi: 10.1074/jbc.M104226200 . PMID   11382783.
• Ford MG, Mills IG, Peter BJ, et al. (2002). "Curvature of clathrin-coated pits driven by epsin". Nature. 419 (6905): 361–6. Bibcode:2002Natur.419..361F. doi:10.1038/nature01020. PMID   12353027. S2CID   4372368.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Koshiba S, Kigawa T, Kikuchi A, Yokoyama S (2003). "Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin". J. Struct. Funct. Genomics. 2 (1): 1–8. doi: 10.1023/A:1011397007366 . PMID   12836669. S2CID   13317798.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Timsit YE, Miller SL, Mohney RP, O'Bryan JP (2005). "The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin". Biochem. Biophys. Res. Commun. 328 (2): 550–9. Bibcode:2005BBRC..328..550T. doi:10.1016/j.bbrc.2005.01.022. PMID   15694383.
• Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly". PLOS Biol. 4 (9): e262. doi: 10.1371/journal.pbio.0040262 . PMC   1540706 . PMID   16903783.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.