RFWD2

Last updated

COP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases COP1 , RNF200, ring finger and WD repeat domain 2, E3 ubiquitin ligase, RFWD2, COP1 E3 ubiquitin ligase, FAP78, CFAP78
External IDs OMIM: 608067; MGI: 1347046; HomoloGene: 115565; GeneCards: COP1; OMA:COP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001740
NM_001286644
NM_022457

NM_011931
NM_001360878

RefSeq (protein)

NP_001001740
NP_001273573
NP_071902

NP_036061
NP_001347807

Location (UCSC) Chr 1: 175.94 – 176.21 Mb Chr 1: 159.06 – 159.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene. [5] [6]

Contents

Interactions

RFWD2 has been shown to interact with C-jun. [7] [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143207 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040782 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang H, Kang D, Deng XW, Wei N (Sep 1999). "Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1". Curr Biol. 9 (13): 711–4. Bibcode:1999CBio....9..711W. doi: 10.1016/S0960-9822(99)80314-5 . PMID   10395541. S2CID   2822539.
  6. "Entrez Gene: RFWD2 ring finger and WD repeat domain 2".
  7. Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM (Feb 2004). "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase" (PDF). Science . 303 (5662): 1371–4. Bibcode:2004Sci...303.1371W. doi:10.1126/science.1093549. PMID   14739464. S2CID   40501515.
  8. Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, Putignano S, Rogge L, Pardi R (May 2003). "Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity". J. Biol. Chem. 278 (22): 19682–90. doi: 10.1074/jbc.M212681200 . hdl: 2434/518351 . PMID   12615916.

Further reading