RGL2

RGL2
Identifiers
Aliases	RGL2 , HKE1.5, KE1.5, RAB2L, ral guanine nucleotide dissociation stimulator like 2
External IDs	OMIM: 602306 MGI: 107483 HomoloGene: 3494 GeneCards: RGL2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,298,942 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,156,661 bp
RNA expression pattern
	Top expressed in
	spleen; ; right uterine tube; ; pituitary gland; ; anterior pituitary; ; right lobe of thyroid gland; ; fundus; ; left lobe of thyroid gland; ; prostate; ; salivary gland; ; minor salivary gland;
	Top expressed in
	lip; ; yolk sac; ; thymus; ; external carotid artery; ; saccule; ; internal carotid artery; ; body of femur; ; superior frontal gyrus; ; blood; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; guanyl-nucleotide exchange factor activity ;
Cellular component	intracellular anatomical structure ; cellular component ;
Biological process	small GTPase mediated signal transduction ; Ras protein signal transduction ; signal transduction ; negative regulation of cardiac muscle cell apoptotic process ; regulation of Ral protein signal transduction ; positive regulation of phosphatidylinositol 3-kinase signaling ; regulation of molecular function ;
	Sources:Amigo / QuickGO
Orthologs
	5863
	19732
ENSG00000228736 ; ENSG00000237441 ; ENSG00000237825 ; ENSG00000224841 ; ENSG00000206282 ;
	n/a
	ENSMUSG00000041354
	O15211
	Q61193
	NM_001243738 ; NM_004761
	NM_009059
	NP_001230667 ; NP_004752
	NP_033085
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Ral guanine nucleotide dissociation stimulator-like 2 is a protein that in humans is encoded by the RGL2 gene.^[5]^[6]

Interactions

RGL2 has been shown to interact with HRAS.^[7]^[8]

Related Research Articles

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Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor.

TAP-associated glycoprotein, also known as tapasin or TAPBP, is a protein that in humans is encoded by the TAPBP gene.

Transporter associated with antigen processing 1 (TAP1) is a protein that in humans is encoded by the TAP1 gene. A member of the ATP-binding cassette transporter family, it is also known as ABCB2.

Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene.

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered exocytosis in neurons.

RalA-binding protein 1 is a protein that in humans is encoded by the RALBP1 gene.

Ral guanine nucleotide dissociation stimulator is a protein that is encoded by the RALGDS gene in humans.

Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.

Coatomer subunit gamma is a protein that in humans is encoded by the COPG gene. It is one of seven proteins in the COPI coatomer complex that coats vesicles as they bud from the Golgi complex.

Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2. This protein is one of two paralogs of the Ral protein, the other being RalA, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

Ras Related Glycolysis Inhibitor and Calcium Channel Regulator (RRAD) is a protein that in humans is encoded by the RRAD gene. RRAD is a Ras-related small GTPase that is regulated by p53 and plays a role in the regulation of aerobic glycolysis.

Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene. RAP2B belongs to the Ras-related protein family.

Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.

Kinesin-associated protein 3 (KAP3) is a protein that in humans is encoded by the KIFAP3 gene. It is a non-motor, accessory subunit which co-oligomerizes with the motor subunits KIF3A and KIF3B or KIF3C, to form heterotrimeric kinesin-2 motor proteins. Kinesin-2 KAP subunits were initially characterized in echinoderms and mice.

Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.

Ras association domain-containing protein 9 (RASSF9), also known as PAM COOH-terminal interactor protein 1 (PCIP1) or peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor (PAMCI) is a protein that in humans is encoded by the RASSF9 gene.

Ras-interacting protein 1(Rain), is a protein that in humans is encoded by the RASIP1 gene.

References

1 2 3 ENSG00000237441, ENSG00000237825, ENSG00000224841, ENSG00000206282 GRCh38: Ensembl release 89: ENSG00000228736, ENSG00000237441, ENSG00000237825, ENSG00000224841, ENSG00000206282 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041354 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (January 1997). "Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS". Cytogenet Cell Genet. 74 (4): 263–5. doi:10.1159/000134431. PMID 8976381.
↑ "Entrez Gene: RGL2 ral guanine nucleotide dissociation stimulator-like 2".
↑ Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi: 10.1074/jbc.M312867200 . PMID 15031288.
↑ Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (November 1996). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". J. Biol. Chem. 271 (47): 29903–8. doi: 10.1074/jbc.271.47.29903 . PMID 8939933.

Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (1997). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". J. Biol. Chem. 271 (47): 29903–8. doi: 10.1074/jbc.271.47.29903 . PMID 8939933.
Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S, Trowsdale J (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC". Eur. J. Immunol. 28 (2): 459–67. doi:10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z. PMID 9521053.
Herberg JA, Beck S, Trowsdale J (1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J. Mol. Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
Ando A, Kikuti YY, Abe K, Shigenari A, Kawata H, Ikemura T, Kimura M, Inoko H (1999). "cDNA cloning, northern hybridization, and mapping analysis of a putative GDS-related protein gene at the centromeric ends of the human and mouse MHC regions". Immunogenetics. 49 (4): 354–6. doi:10.1007/s002510050504. PMID 10079301. S2CID 30077097.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi: 10.1074/jbc.M312867200 . PMID 15031288.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000237441, ENSG00000237825, ENSG00000224841, ENSG00000206282 GRCh38: Ensembl release 89: ENSG00000228736, ENSG00000237441, ENSG00000237825, ENSG00000224841, ENSG00000206282 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041354 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8976381-5] Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (January 1997). "Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS". Cytogenet Cell Genet. 74 (4): 263–5. doi:10.1159/000134431. PMID 8976381.

[entrez-6] "Entrez Gene: RGL2 ral guanine nucleotide dissociation stimulator-like 2".

[pmid15031288-7] Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi: 10.1074/jbc.M312867200 . PMID 15031288.

[pmid8939933-8] Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (November 1996). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". J. Biol. Chem. 271 (47): 29903–8. doi: 10.1074/jbc.271.47.29903 . PMID 8939933.

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RGL2

Contents

Interactions

Related Research Articles

References

Further reading