RMND5B | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | RMND5B , GID2, GID2B, required for meiotic nuclear division 5 homolog B | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1913339 HomoloGene: 100777 GeneCards: RMND5B | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Required for meiotic nuclear division 5 homolog B (S. cerevisiae), also known as RMND5B, is a protein which in humans is encoded by the RMND5B gene. [5] It has a zinc finger domain and is highly conserved throughout many eukaryotic organisms.
This protein is rich in leucine (14.0%) and might belong to the protein family of leucine-rich repeats
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CAD28476 is highly conserved in many eukaryotic organism. Its high conservation suggests that it plays a primary role in meiosis.
taxonomic name | common name | NCBI entry | Percentage of sequence similarity | Length (AAs) | comments |
Homo sapiens | Human | 100% | 393 | hypothetical Protein for Meiosis | |
Pan troglodytes | Chimpanzee | 99.7% | 393 | required for meiotic nuclear division 5 homolog B isoform 6 | |
Macaca mulatta | Rhesus macaque | 98.5% | 393 | Similar to CG3295-PA isoform 11 | |
Rattus norvegicus | Norway rat | 98.2% | 393 | Similar to RIKEN cDNA 0610039K22 | |
Mus musculus | House mouse | 97.7% | 393 | Required for meiotic nuclear division 5 homolog B | |
Equus caballus | Horse | 97.7% | 273 | PREDICTED: similar required for meiotic nuclear division 5 homolog B | |
Bos taurus | Cattle | 95.4% | 393 | required for meiotic nuclear division 5 homolog B | |
Danio rerio | Zebrafish | 72.8% | 391 | required for meiotic nuclear division 5 homolog B | |
Xenopus laevis | African clawed frog | 70% | 391 | MGC84431 protein | |
Canis lupus familiaris | Dog | 70% | 391 | PREDICTED: similar to CG3295-PA isoform A | |
Tetraodon nigroviridis | Spotted green pufferfish | 68.5% | 417 | unnamed protein product | |
Ornithorhynchus anatinus | Platypus | 64.5% | 389 | ||
Branchiostoma floridae | Florida lancelet | 57% | 491 | hypothetical protein BRAFLDRAFT_126901 | |
Nematostella vectensis | Sea anemone | 50.1% | 389 | ||
Culex quinquefasciatus | Southern house mosquito | 48.5% | 392 | conserved hypothetical protein | |
Aedes aegypti | Yellow fever mosquito | 48.2% | 392 | hypothetical protein AaeL_AAEL009407 | |
Strongylocentrotus purpuratus | Purple urchin | 48.2 | 405 | PREDICTED: Similar to MGC88921 protein | |
Drosophila virilis | Fruit fly | 41.5% | 437 | GJ20343 | |
Drosophila melanogaster | Fruit fly | 40.3% | 431 | CG3295 | |
Acyrthosiphon pisum | Acrythosiphon | 39.5% | 366 | PREDICTED: required for meiothic nuclear division 5 homolg A | |
Oryza sativa | Rice | 32.2% | 386 | membrane protein-like | |
Two domains were predicted by the program BLIMPS [6] to exist in the protein of which one of the domains contains a zinc finger domain.
Zinc finger domains assist the binding of the protein to nucleic acids. This points to a direct interaction of CAD28476 with DNA during meiosis. By comparing CAD28476 with a related zinc finger protein [7] in a local sequence alignment using LALIGN, [8] the amino acids His359, Cys381 and Cys384 could be attributed to the zinc finger domain. This zinc finger structure is uncommon in the way that it involves one histidine instead of two.
Microarray data show that CAD28476 is highly expressed in tissue where meiosis occurs like in testis and ovaries. Moreover, it is also highly expressed in the brain around the hypothalamus.
The analysis of the promoter region (tools on the page rVista . [9] were used) shows that there are several transcription factor binding sites localized in conserved regions . It is very likely that the transcription factor Ets-1 which belongs to the ETS transcription factor family and its core binding factor CBF are involved in regulation of transcription since they both have independent binding sites.
There were two proteins predicted [10] which interact with CAD28476.
name of the protein | Uniprot entry | information about the gene |
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Ewing sarcoma breakpoint region 1, isoform CRA_a | gene encodes a putative RNA binding protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. | |
Mothers against decapentaplegic homolog 4 | SMAD4 |
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. It was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog (Xenopus laevis) transcription factor IIIA. However, it has been found to encompass a wide variety of differing protein structures in eukaryotic cells. Xenopus laevis TFIIIA was originally demonstrated to contain zinc and require the metal for function in 1983, the first such reported zinc requirement for a gene regulatory protein followed soon thereafter by the Krüppel factor in Drosophila. It often appears as a metal-binding domain in multi-domain proteins.
EGR-1 also known as ZNF268 or NGFI-A is a protein that in humans is encoded by the EGR1 gene.
Zinc finger protein 281 is a protein that in humans is encoded by the ZNF281 gene.
Zinc finger protein 593 is a protein that in humans is encoded by the ZNF593 gene.
Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.
Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.
Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.
RNA binding motif protein 9 (RBM9), also known as Rbfox2, is a protein which in humans is encoded by the RBM9 gene.
CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.
Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.
Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.
Zinc finger protein 161 homolog is a protein that in humans is encoded by the ZFP161 gene.
Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.
Zinc finger protein 366, also known as DC-SCRIPT, is a protein that in humans is encoded by the ZNF366 gene. The ZNF366 gene was first identified in a DNA comparison study between 85 kb of Fugu rubripes sequence containing 17 genes with its homologous loci in the human draft genome.
Arf-GAP domain and FG repeats-containing protein 2 is a protein that in humans is encoded by the AGFG2 gene.
Zinc finger protein 19 is a protein that in humans is encoded by the ZNF19 gene.
Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.
Zinc finger protein 133 is a protein that in humans is encoded by the ZNF133 gene.
High mobility group nucleosome-binding domain-containing protein 4 is a transcription factor that in humans is encoded by the HMGN4 gene.
Zinc finger protein 184, also known as ZNF184, is a protein that in humans is encoded by the ZNF184 gene on chromosome 6. It was first identified by Goldwurm et al. in 1996.