RNF135

RNF135
Identifiers
Aliases	RNF135 , MMFD, REUL, Riplet, L13, ring finger protein 135
External IDs	OMIM: 611358 MGI: 1919206 HomoloGene: 12427 GeneCards: RNF135
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q11.2 Start 30,970,984 bp [1] End 30,999,911 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 B5|11 47.59 cM Start 80,074,677 bp [2] End 80,090,583 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell parietal pleura synovial membrane visceral pleura secondary oocyte human penis synovial joint nipple amniotic fluid monocyte Top expressed in proximal tubule interventricular septum utricle left lobe of liver spleen lacrimal gland ciliary body islet of Langerhans yolk sac stria vascularis More reference expression data BioGPS n/a
Gene ontology Molecular function ribonucleoprotein complex binding protein binding metal ion binding ubiquitin-protein transferase activity identical protein binding transferase activity Cellular component cytoplasm cytosol Biological process positive regulation of interferon-beta production negative regulation of type I interferon production innate immune response regulation of innate immune response protein ubiquitination immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84282 71956 Ensembl ENSG00000181481 ENSMUSG00000020707 UniProt Q8IUD6 Q9CWS1 RefSeq (mRNA) NM_001184992 NM_032322 NM_197939 NM_028019 RefSeq (protein) NP_001171921 NP_115698 NP_922921 NP_082295 Location (UCSC) Chr 17: 30.97 – 31 Mb Chr 11: 80.07 – 80.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene. ^{[5] [6] [7]}

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. ^[7]

Interactions

RNF135 has been shown to interact with RARRES3. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000181481 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020707 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H (Aug 2001). "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet. 69 (3): 516–27. doi:10.1086/323043. PMC   1235482 . PMID   11468690.
6. Oshiumi H, Matsumoto M, Hatakeyama S, Seya T (Jan 2009). "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J Biol Chem. 284 (2): 807–17. doi: 10.1074/jbc.M804259200 . PMID   19017631.
7. "Entrez Gene: RNF135 ring finger protein 135".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jenne DE, Tinschert S, Dorschner MO, et al. (2003). "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse". Genes Chromosomes Cancer. 37 (2): 111–20. doi:10.1002/gcc.10206. PMID   12696059. S2CID   37232718.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi: 10.1038/sj.onc.1207921 . PMID   15334068.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID   17632510. S2CID   35797973.