RNF38

RNF38
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X4J, 4V3K, 4V3L
Identifiers
Aliases	RNF38 , ring finger protein 38
External IDs	OMIM: 612488 MGI: 1920719 HomoloGene: 32550 GeneCards: RNF38
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p13.2 Start 36,336,396 bp [1] End 36,487,548 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 B1 Start 44,126,210 bp [2] End 44,233,789 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte ganglionic eminence metanephric glomerulus germinal epithelium Brodmann area 23 corpus epididymis parietal pleura endothelial cell middle temporal gyrus Top expressed in secondary oocyte seminiferous tubule aortic valve ascending aorta blood ganglionic eminence cumulus cell medial ganglionic eminence ciliary body thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding ubiquitin-protein transferase activity ubiquitin protein ligase activity transferase activity Cellular component sperm flagellum nucleus nucleoplasm Biological process male gonad development protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 152006 73469 Ensembl ENSG00000137075 ENSMUSG00000035696 UniProt Q9H0F5 Q8BI21 RefSeq (mRNA) NM_022781 NM_194328 NM_194329 NM_194330 NM_194331 NM_194332 NM_001038993 NM_175201 NM_001355181 NM_001379574 NM_001379575 NM_001379576 NM_001379577 NM_001379578 NM_001379579 NM_001379580 NM_001379581 RefSeq (protein) NP_073618 NP_919309 NP_919310 NP_919311 NP_919313 NP_001034082 NP_780410 NP_001342110 NP_001366503 NP_001366504 NP_001366505 NP_001366506 NP_001366507 NP_001366508 NP_001366509 NP_001366510 Location (UCSC) Chr 9: 36.34 – 36.49 Mb Chr 4: 44.13 – 44.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RING finger protein 38 is a protein that in humans is encoded by the RNF38 gene. ^[5]

This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. ^[5]

See also

• RING finger domain

References

1. GRCh38: Ensembl release 89: ENSG00000137075 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035696 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RNF38 ring finger protein 38".

Further reading

• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–374. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Eisenberg I, Hochner H, Levi T, et al. (2002). "Cloning and characterization of a novel human gene RNF38 encoding a conserved putative protein with a RING finger domain". Biochem. Biophys. Res. Commun. 294 (5): 1169–1176. doi:10.1016/S0006-291X(02)00584-3. PMID   12074600.
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–15094. Bibcode:2001PNAS...9815089X. doi: 10.1073/pnas.241522398 . PMC   64988 . PMID   11752456.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.

External links

• RNF38+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)