RREB1

RREB1
Identifiers
Aliases	RREB1 , FINB, HNT, LZ321, RREB-1, Zep-1, ras responsive element binding protein 1
External IDs	OMIM: 602209 MGI: 2443664 HomoloGene: 2218 GeneCards: RREB1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	7,251,980 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	38,135,981 bp
RNA expression pattern
	Top expressed in
	oral cavity; ; sural nerve; ; parotid gland; ; epithelium of esophagus; ; lactiferous duct; ; spongy bone; ; jejunal mucosa; ; body of tongue; ; human penis; ; nipple;
	Top expressed in
	left lung lobe; ; substantia nigra; ; pineal gland; ; ciliary body; ; lacrimal gland; ; Paneth cell; ; conjunctival fornix; ; olfactory tubercle; ; molar; ; left colon;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding ; metal ion binding ; nucleic acid binding ; RNA polymerase II core promoter sequence-specific DNA binding ; RNA polymerase II transcription regulatory region sequence-specific DNA binding ; DNA-binding transcription activator activity, RNA polymerase II-specific ; DNA-binding transcription factor activity ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nuclear body ; extracellular exosome ; fibrillar center ; nucleus ; cytoplasm ; nuclear speck ;
Biological process	positive regulation of mammary gland epithelial cell proliferation ; positive regulation of lamellipodium morphogenesis ; regulation of transcription, DNA-templated ; positive regulation of epithelial cell migration ; transcription by RNA polymerase II ; transcription, DNA-templated ; multicellular organism development ; positive regulation of transcription, DNA-templated ; positive regulation of substrate adhesion-dependent cell spreading ; Ras protein signal transduction ; negative regulation of transcription, DNA-templated ; positive regulation of wound healing, spreading of epidermal cells ; negative regulation of transcription by RNA polymerase II ; positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	6239
	68750
	ENSG00000124782
	ENSMUSG00000039087
	Q92766
	Q3UH06
	NM_001003698 ; NM_001003699 ; NM_001003700 ; NM_001168344 ; NM_002955 Contents Clinical significance ; References ; Further reading ;
	NM_001013392 ; NM_001039188 ; NM_001177868 ; NM_001177869 ; NM_026830
NP_001003698 ; NP_001003699 ; NP_001003700 ; NP_001161816 ; NP_001003698.1 ;
	NP_001161816.1
NP_001034277 ; NP_001171339 ; NP_001171340 ; NP_081106 ; NP_001391686 ;
	NP_001391687 ; NP_001391688 ; NP_001391689
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 12, 2024

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.^[5]^[6]^[7]

Clinical significance

Mutations in RREB1 are associated to type 2 diabetes associated end-stage kidney disease.^[8]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124782 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039087 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD (Jan 1998). "RREB1, a ras responsive element binding protein, maps to human chromosome 6p25". Genomics. 45 (3): 630–632. doi: 10.1006/geno.1997.5001 . PMID 9367691.
↑ Melani M, Simpson KJ, Brugge JS, Montell D (Apr 2008). "Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1". Curr Biol. 18 (7): 532–537. Bibcode:2008CBio...18..532M. doi: 10.1016/j.cub.2008.03.024 . PMID 18394891. S2CID 17251337.
↑ "Entrez Gene: RREB1 ras responsive element binding protein 1".
↑ Bonomo JA, Guan M, Ng MC, Palmer ND, Hicks PJ, Keaton JM, Lea JP, Langefeld CD, Freedman BI, Bowden DW (2014). "The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease". Human Molecular Genetics. 23 (24): 6441–7. doi:10.1093/hmg/ddu362. PMC 4240197 . PMID 25027322.

Thiagalingam A, De Bustros A, Borges M, Jasti R, Compton D, Diamond L, Mabry M, Ball DW, Baylin SB (1996). "RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas". Mol. Cell. Biol. 16 (10): 5335–45. doi:10.1128/mcb.16.10.5335. PMC 231532 . PMID 8816445.
Fujimoto-Nishiyama A, Ishii S, Matsuda S, Inoue JI, Yamamoto T (1997). "A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies". Gene. 195 (2): 267–275. doi:10.1016/S0378-1119(97)00172-8. PMID 9305772.
Zhang L, Zhao J, Edenberg HJ (1999). "A human Raf-responsive zinc-finger protein that binds to divergent sequences". Nucleic Acids Res. 27 (14): 2947–2956. doi:10.1093/nar/27.14.2947. PMC 148511 . PMID 10390538.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ray SK, Nishitani J, Petry MW, Fessing MY, Leiter AB (2003). "Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1". Mol. Cell. Biol. 23 (1): 259–271. doi:10.1128/MCB.23.1.259-271.2003. PMC 140679 . PMID 12482979.
Zhang S, Qian X, Redman C, Bliskovski V, Ramsay ES, Lowy DR, Mock BA (2003). "p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB". Oncogene. 22 (15): 2285–2295. doi:10.1038/sj.onc.1206257. PMID 12700664. S2CID 917155.
Shi Y, Sawada J, Sui G, Affar EB, Whetstine JR, Lan F, Ogawa H, Po-Shan Luke M, Nakatani Y (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–738. Bibcode:2003Natur.422..735S. doi:10.1038/nature01550. PMID 12700765. S2CID 2670859.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Date S, Nibu Y, Yanai K, Hirata J, Yagami K, Fukamizu A (2005). "Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene". Int. J. Mol. Med. 13 (5): 637–42. doi:10.3892/ijmm.13.5.637. PMID 15067362.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124782 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039087 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9367691-5] Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD (Jan 1998). "RREB1, a ras responsive element binding protein, maps to human chromosome 6p25". Genomics. 45 (3): 630–632. doi: 10.1006/geno.1997.5001 . PMID 9367691.

[pmid18394891-6] Melani M, Simpson KJ, Brugge JS, Montell D (Apr 2008). "Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1". Curr Biol. 18 (7): 532–537. Bibcode:2008CBio...18..532M. doi: 10.1016/j.cub.2008.03.024 . PMID 18394891. S2CID 17251337.

[entrez-7] "Entrez Gene: RREB1 ras responsive element binding protein 1".

[8] Bonomo JA, Guan M, Ng MC, Palmer ND, Hicks PJ, Keaton JM, Lea JP, Langefeld CD, Freedman BI, Bowden DW (2014). "The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease". Human Molecular Genetics. 23 (24): 6441–7. doi:10.1093/hmg/ddu362. PMC 4240197 . PMID 25027322.

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RREB1

Contents

Clinical significance

Related Research Articles

References

Further reading