RREB1

Last updated

RREB1
Identifiers
Aliases RREB1 , FINB, HNT, LZ321, RREB-1, Zep-1, ras responsive element binding protein 1
External IDs OMIM: 602209; MGI: 2443664; HomoloGene: 2218; GeneCards: RREB1; OMA:RREB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001003698
NM_001003699
NM_001003700
NM_001168344
NM_002955

Contents

NM_001013392
NM_001039188
NM_001177868
NM_001177869
NM_026830

RefSeq (protein)
Location (UCSC) Chr 6: 7.11 – 7.25 Mb Chr 13: 37.96 – 38.14 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene. [5] [6] [7]

Clinical significance

Mutations in RREB1 are associated to type 2 diabetes associated end-stage kidney disease. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000124782 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039087 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD (Jan 1998). "RREB1, a ras responsive element binding protein, maps to human chromosome 6p25". Genomics. 45 (3): 630–632. doi: 10.1006/geno.1997.5001 . PMID   9367691.
  6. Melani M, Simpson KJ, Brugge JS, Montell D (Apr 2008). "Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1". Curr Biol. 18 (7): 532–537. Bibcode:2008CBio...18..532M. doi: 10.1016/j.cub.2008.03.024 . PMID   18394891. S2CID   17251337.
  7. "Entrez Gene: RREB1 ras responsive element binding protein 1".
  8. Bonomo JA, Guan M, Ng MC, Palmer ND, Hicks PJ, Keaton JM, Lea JP, Langefeld CD, Freedman BI, Bowden DW (2014). "The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease". Human Molecular Genetics. 23 (24): 6441–7. doi:10.1093/hmg/ddu362. PMC   4240197 . PMID   25027322.

Further reading